{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:32:35Z","timestamp":1793331155545,"version":"4.5.0"},"reference-count":40,"publisher":"American Veterinary Medical Association (AVMA)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2020,2,1]]},"abstract":"Abstract<\/jats:title>\n\nOBJECTIVE<\/jats:title>\nTo evaluate and compare the clinical usefulness of plasma atrial natriuretic peptide (ANP) and cardiac troponin-I (cTnI) concentrations for assessment of disease severity in dogs with naturally occurring mitral valve disease (MVD).<\/jats:p>\n<\/jats:sec>\n\nANIMALS<\/jats:title>\n316 dogs with MVD and 40 healthy control dogs.<\/jats:p>\n<\/jats:sec>\n\nPROCEDURES<\/jats:title>\nEach dog underwent a physical examination and echocardiographic and thoracic radiographic assessments. Blood samples were obtained and processed for measurement of plasma ANP and cTnI concentrations. Dogs with MVD were categorized into 3 groups (stages B1 [no clinical signs or evidence of cardiac enlargement], B2 [no clinical signs with evidence of cardiac enlargement], and C [history of congestive heart failure and pulmonary edema]) on the basis of American College of Veterinary Internal Medicine guidelines. Receiver operating characteristic curve analysis was used to evaluate the accuracy of plasma ANP and cTnI concentrations for assessment of MVD severity.<\/jats:p>\n<\/jats:sec>\n\nRESULTS<\/jats:title>\nPlasma ANP and cTnI concentrations increased as disease severity increased. Median plasma ANP concentrations for all 3 MVD groups and median plasma cTnI concentrations for the stage B2 and C groups were significantly greater than the corresponding concentrations for the control group. Plasma ANP concentration, but not cTnI concentration, appeared to be useful for detection of dogs with subclinical (stages B1 and B2) MVD, whereas both concentrations appeared useful for detection of dogs with stage C MVD.<\/jats:p>\n<\/jats:sec>\n\nCONCLUSIONS AND CLINICAL RELEVANCE<\/jats:title>\nResults indicated that plasma ANP and cTnI concentrations should not be used independently to diagnose MVD but can be used to assess MVD severity and supplement echocardiographic findings.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/javma.256.3.340","type":"journal-article","created":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T14:44:08Z","timestamp":1579617848000},"page":"340-348","source":"Crossref","is-referenced-by-count":11,"title":["Evaluation of atrial natriuretic peptide and cardiac troponin I concentrations for assessment of disease severity in dogs with naturally occurring mitral valve disease"],"prefix":"10.2460","volume":"256","author":[{"given":"Yasutomo","family":"Hori","sequence":"first","affiliation":[{"name":"1School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido 069-8501, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Iguchi","sequence":"additional","affiliation":[{"name":"2Iguchi Animal Hospital, 6-2-34 Kamijima, Naka Ward, Hamamatsu, Shizuoka 433-8122, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Hirakawa","sequence":"additional","affiliation":[{"name":"3Pet Clinic Hallelujah, 2544-1 Nakabaru, Kasuya-machi, Kasuya County, Fukuoka 811-2304, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zenta","family":"Kamiya","sequence":"additional","affiliation":[{"name":"4Esora Animal Hospital, 5-3-10 Togasaki, Nishio, Aichi 445-0075, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeki","family":"Yamano","sequence":"additional","affiliation":[{"name":"5Ueda Animal Clinic, 2-202 Ueda, Tenpaku Ward, Nagoya, Aichi 468-0051, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiki","family":"Ibaragi","sequence":"additional","affiliation":[{"name":"6Miyoshi Inter Animal Hospital, 3-1-8 Neura-machi, Miyoshi, Aichi 470-0217, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Isayama","sequence":"additional","affiliation":[{"name":"7Uenonomori Animal Clinic, 1-5-11 Yanaka Taito Ward, Tokyo, 110-0001, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Yamashita","sequence":"additional","affiliation":[{"name":"8Ebisu Animal Hospital, 3-3-43 Nishitaga, Taihaku Ward, Sendai, Miyagi 982-0034, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Iwasa","sequence":"additional","affiliation":[{"name":"9Hashima Animal Hospital, 2-17 Asahira, Fukujyu-cho, Hashima, Gifu 501-6255, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruki","family":"Inaba","sequence":"additional","affiliation":[{"name":"10Inaba Veterinary Hospital, 533-2 Shimojo, Fujinomiya, Shizuoka, 418-0114, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Heishima","sequence":"additional","affiliation":[{"name":"1School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido 069-8501, Japan."},{"name":"11Heisei Animal Hospital, 2-1-1 Futago-cho, Kasugai, Aichi 486-0955, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Yuki","sequence":"additional","affiliation":[{"name":"12Yuki Animal Hospital, 2-99 Kiba-cho, Minato-ku, Nagoya, Aichi 455-0021, 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