{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:45:39Z","timestamp":1790793939149,"version":"4.1.0"},"reference-count":18,"publisher":"American Veterinary Medical Association (AVMA)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2020,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec id=\"s001\">\n<jats:title>CASE DESCRIPTION<\/jats:title>\n<jats:p>A 17-week-old 14.4-kg (31.7-lb) female German Shepherd Dog from Missouri with a history of multiple intermittent episodes of vomiting and diarrhea underwent exploratory celiotomy.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s002\">\n<jats:title>CLINICAL FINDINGS<\/jats:title>\n<jats:p>At the time of surgery, the dog was bright, alert, and responsive, with a tender abdomen and palpable mesenteric lymph nodes. Hematologic data revealed mild leukocytosis, mild hypoproteinemia, and mild hypoalbuminemia. Moderate petechiation of the jejunal serosa and prominent mesenteric lymph nodes, but no palpable obstructions, were found during surgery. Jejunal and lymph node biopsies were performed; histologic examination revealed multiple segments of adult cestodes up to 700 \u03bcm long in the jejunum. Segments had a scolex and contained approximately 30- to 35-\u03bcm-diameter ova, morphologically compatible with <jats:italic>Echinococcus<\/jats:italic> spp. Fecal flotation revealed numerous proglottids and ova similar to those recognized histologically. Results of PCR assays confirmed <jats:italic>Echinococcus multilocularis of<\/jats:italic> E4 haplotype (a European strain).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s003\">\n<jats:title>TREATMENT AND OUTCOME<\/jats:title>\n<jats:p>Praziquantel (5 mg\/kg [2.3 mg\/lb], SC, once) was administered after surgery; treatments after hospital discharge included praziquantel (10 mg\/kg [4.5 mg\/lb], PO, once). No proglottids or ova were observed by fecal flotation after the treatments. The dog remained healthy without gastrointestinal signs 1 year later.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s004\">\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>The dog of this report had no travel history outside the state of Missouri. To the authors\u2019 knowledge, this is the first report of intestinal <jats:italic>E multilocularis<\/jats:italic> infection in a pet dog in the contiguous United States and first detection of a European strain of <jats:italic>E multilocularis<\/jats:italic> in this country. Findings suggested possible establishment of a European strain of this zoonotic pathogen in the contiguous United States.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/javma.256.9.1041","type":"journal-article","created":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T15:10:27Z","timestamp":1587136227000},"page":"1041-1046","source":"Crossref","is-referenced-by-count":16,"title":["Intestinal echinococcosis in a dog from Missouri"],"prefix":"10.2460","volume":"256","author":[{"given":"Keiichi","family":"Kuroki","sequence":"first","affiliation":[{"name":"1Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211."},{"name":"2Veterinary Medical Diagnostic Laboratory, University of Missouri, Columbia, MO 65211."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Morishima","sequence":"additional","affiliation":[{"name":"3Department of Parasitology, National Institute of Infectious Diseases, Tokyo, 162-8640, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Neil","sequence":"additional","affiliation":[{"name":"4Noah's Ark Animal Hospital & Bird Clinic, Columbia, MO 65203."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda T.","family":"Beerntsen","sequence":"additional","affiliation":[{"name":"1Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"5College of Veterinary Medicine, Nihon University, Kanagawa, 252-8510, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger W.","family":"Stich","sequence":"additional","affiliation":[{"name":"1Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Echinococcus multilocularis. 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