{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T07:15:25Z","timestamp":1760080525015},"reference-count":30,"publisher":"American Veterinary Medical Association (AVMA)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2021,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec id=\"s001\">\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>To compare immune responses induced by 2 commercially available vaccines with a bovine herpesvirus type 1 (BHV1) component following intranasal (IN) administration to colostrum-fed calves.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s002\">\n<jats:title>ANIMALS<\/jats:title>\n<jats:p>90 male Holstein calves (ages, 5 to 14 days).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s003\">\n<jats:title>PROCEDURES<\/jats:title>\n<jats:p>In a randomized complete block design, each calf received 2 mL (1 mL\/nostril) of vaccine A (n = 30), vaccine B (30), or saline (0.9% NaCl) solution (30) on day 0. Blood samples were collected for determination of serum anti-BHV1 IgG titer, and nasal fluid (NF) samples were collected for determination of interferon (IFN)-\u03b1 and IFN-\u03b3 concentrations and for secretory IgA titers against BHV1, <jats:italic>Mannheimia haemolytica<\/jats:italic>, and <jats:italic>Pasteurella multocida<\/jats:italic> at predetermined times for 42 days after vaccination.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s004\">\n<jats:title>RESULTS<\/jats:title>\n<jats:p>All calves were seropositive for anti-BHV1 IgG, and the mean anti-BHV1 IgG titer did not differ significantly among the 3 groups at any time. Both vaccines induced significant transient increases in NF IFN-\u03b1 and IFN-\u03b3 concentrations. On day 5, mean IFN-\u03b1 concentration and the proportion of calves with detectable IFN-\u03b1 concentrations for the vaccine A group were significantly greater than those for the vaccine B and control groups. On day 42, the mean NF anti\u2013<jats:italic>P multocida<\/jats:italic> IgA titers for both vaccine groups were significantly greater than that of the control group.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s005\">\n<jats:title>CONCLUSIONS AND CLINICAL RELEVANCE<\/jats:title>\n<jats:p>Both vaccines induced innate and acquired immune responses in calves with colostral antibodies. The magnitude of the IFN-\u03b1 response and proportion of calves with detectable IFN-\u03b1 differed between the 2 vaccine groups. Both vaccines appeared to enhance the IgA response against <jats:italic>P multocida<\/jats:italic>.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/javma.258.10.1119","type":"journal-article","created":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T15:22:45Z","timestamp":1620141765000},"page":"1119-1129","source":"Crossref","is-referenced-by-count":6,"title":["Innate and acquired immune responses of colostrum-fed neonatal Holstein calves following intranasal vaccination with two commercially available modified-live virus vaccines"],"prefix":"10.2460","volume":"258","author":[{"given":"Lowell T.","family":"Midla","sequence":"first","affiliation":[{"name":"From Merck Animal Health, Madison, NJ 07940."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin L.","family":"Hill","sequence":"additional","affiliation":[{"name":"From Merck Animal Health, Madison, NJ 07940."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas K.","family":"Van Engen","sequence":"additional","affiliation":[{"name":"Johnson Research LLC, Parma, ID 83660."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Edmonds","sequence":"additional","affiliation":[{"name":"Johnson Research LLC, Parma, ID 83660."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David G.","family":"Renter","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marshall N.","family":"Streeter","sequence":"additional","affiliation":[{"name":"From Merck Animal Health, Madison, NJ 07940."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P.","family":"Hutcheson","sequence":"additional","affiliation":[{"name":"From Merck Animal Health, Madison, NJ 07940."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip J.","family":"Griebel","sequence":"additional","affiliation":[{"name":"Vaccine and Infectious Disease Organization (VIDO)\u2013Intervac, University of Saskatchewan, Saskatoon, SK S7N 5E3, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"R1","series-title":"Anim Health Res Rev","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1017\/S146625230999017X","article-title":"Bovine respiratory disease research 1983\u20132009","volume":"10","author":"Fulton RW","year":"2009","unstructured":"Fulton RW. 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