{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:51:17Z","timestamp":1791287477121,"version":"4.1.0"},"reference-count":30,"publisher":"American Veterinary Medical Association (AVMA)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2021,4,1]]},"abstract":"Abstract<\/jats:title>\n\nCASE DESCRIPTION<\/jats:title>\n2 male and 3 female adult bearded dragons (Pogona vitticeps<\/jats:italic>) were evaluated at the North Carolina State University College of Veterinary Medicine's Exotic Animal Medicine Service between September 2018 and October 2019 because of severe lymphocytosis.<\/jats:p>\n<\/jats:sec>\n\nCLINICAL FINDINGS<\/jats:title>\nAll 5 bearded dragons had nonspecific clinical signs, including lethargy, poor appetite, ocular discharge, and weight loss. Clinicopathologic testing revealed extremely high lymphocyte counts with morphological findings consistent with lymphocytic leukemia.<\/jats:p>\n<\/jats:sec>\n\nTREATMENT AND OUTCOME<\/jats:title>\nAll 5 patients were treated with lomustine, prednisolone, and antimicrobials. In addition, 1 or 2 doses of L-asparaginase were administered when the drug was available. Partial remission was achieved in all 5 patients. One patient, after disease progression was documented, was treated with cyclophosphamide and achieved a second partial remission. One of the 5 patients was still alive and continuing to receive chemotherapy at the time of final follow-up 244 days after the initial diagnosis. Survival times (ie, times from initial diagnosis to euthanasia) for the other 4 patients were 57, 157, 330, and 416 days.<\/jats:p>\n<\/jats:sec>\n\nCLINICAL RELEVANCE<\/jats:title>\nThe present report represented the first description of lomustine as a primary chemotherapeutic agent for the treatment of lymphocytic leukemia in bearded dragons and provided information on response to treatment, adverse effects, and survival times.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/javma.258.7.748","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T13:30:56Z","timestamp":1616506256000},"page":"748-757","source":"Crossref","is-referenced-by-count":10,"title":["Lymphoid leukemia in five bearded dragons (Pogona vitticeps)"],"prefix":"10.2460","volume":"258","author":[{"given":"Caitlin M.","family":"Hepps Keeney","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne L.","family":"Intile","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cory S.","family":"Sims","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara M.","family":"Harrison","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"R1","series-title":"Exotic animal formulary","first-page":"124","article-title":"Reptiles","author":"Klaphake E","year":"2018","unstructured":"Klaphake E, Gibbons PM, Sladky KK, Reptiles. 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