{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T18:07:28Z","timestamp":1793124448998,"version":"4.5.0"},"reference-count":42,"publisher":"American Veterinary Medical Association (AVMA)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2021,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec id=\"s001\">\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>To estimate the prevalence of extended-spectrum cephalosporin-, carbapenem-, and fluoroquinolone-resistant bacteria of the family Enterobacteriaceae in the feces of hospitalized horses and on hospital surfaces.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s002\">\n<jats:title>SAMPLE<\/jats:title>\n<jats:p>Fecal and environmental samples were collected from The Ohio State University Galbreath Equine Center (OSUGEC) and a private referral equine hospital in Kentucky (KYEH). Feces were sampled within 24 hours after hospital admission and after 48 hours and 3 to 7 days of hospitalization.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s003\">\n<jats:title>PROCEDURES<\/jats:title>\n<jats:p>Fecal and environmental samples were enriched, and then selective media were inoculated to support growth of Enterobacteriaceae bacteria that expressed resistance phenotypes to extended-spectrum cephalosporins, carbapenems, and fluoroquinolones.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s004\">\n<jats:title>RESULTS<\/jats:title>\n<jats:p>358 fecal samples were obtained from 143 horses. More samples yielded growth of Enterobacteriaceae bacteria that expressed resistance phenotypes (AmpC \u03b2-lactamase, OR = 4.2; extended-spectrum beta-lactamase, OR = 3.2; and fluoroquinolone resistance, OR = 4.0) after 48 hours of hospitalization, versus within 24 hours of hospital admission. Horses hospitalized at KYEH were at greater odds of having fluoroquinolone-resistant bacteria (OR = 2.2). At OSUGEC, 82%, 64%, 0%, and 55% of 164 surfaces had Enterobacteriaceae bacteria with AmpC \u03b2-lactamase phenotype, extended-spectrum beta-lactamase phenotype, resistance to carbapenem, and resistance to fluoroquinolones, respectively; prevalences at KYEH were similarly distributed (52%, 32%, 1%, and 35% of 315 surfaces).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s005\">\n<jats:title>CONCLUSIONS AND CLINICAL RELEVANCE<\/jats:title>\n<jats:p>Results indicated that antimicrobial-resistant Enterobacteriaceae may be isolated from the feces of hospitalized horses and from the hospital environment. Hospitalization may lead to increased fecal carriage of clinically important antimicrobial-resistance genes.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/javma.258.7.758","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T13:30:56Z","timestamp":1616506256000},"page":"758-766","source":"Crossref","is-referenced-by-count":6,"title":["Prevalence of extended-spectrum cephalosporin-, carbapenem-, and fluoroquinolone-resistant members of the family Enterobacteriaceae isolated from the feces of horses and hospital surfaces at two equine specialty hospitals"],"prefix":"10.2460","volume":"258","author":[{"given":"Rachael J.","family":"Adams","sequence":"first","affiliation":[{"name":"Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dixie F.","family":"Mollenkopf","sequence":"additional","affiliation":[{"name":"Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitria A.","family":"Mathys","sequence":"additional","affiliation":[{"name":"Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Whittle","sequence":"additional","affiliation":[{"name":"Rood & Riddle Equine Hospital, Lexington, KY 40511."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg A.","family":"Ballash","sequence":"additional","affiliation":[{"name":"Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Mudge","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua B.","family":"Daniels","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210."},{"name":"Veterinary Diagnostic Laboratories, Colorado State University, Fort Collins, CO 80526."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonnie","family":"Barr","sequence":"additional","affiliation":[{"name":"Rood & Riddle Equine Hospital, Lexington, KY 40511."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Wittum","sequence":"additional","affiliation":[{"name":"Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"R1","series-title":"Int J Antimicrob Agents","first-page":"431","article-title":"Use of antimicrobial agents in veterinary medicine and food animal production","volume":"17","author":"Schwarz S","year":"2001","unstructured":"Schwarz S, Kehrenberg C, Walsh TR. 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