{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T01:05:30Z","timestamp":1774314330347,"version":"3.50.1"},"reference-count":30,"publisher":"American Veterinary Medical Association (AVMA)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2021,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec id=\"s001\">\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>To evaluate the effects of <jats:italic>Toxoplasma gondii<\/jats:italic> infection in feline renal transplant recipients with a preoperative seronegative or unknown serostatus (SN-UNK) for <jats:italic>T gondii<\/jats:italic> and the efficacy of lifelong prophylactic treatment of <jats:italic>T gondii<\/jats:italic> infection in feline renal transplant recipients with a preoperative seropositive serostatus (SP) for <jats:italic>T gondii<\/jats:italic>.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s002\">\n<jats:title>ANIMALS<\/jats:title>\n<jats:p>24 cats with various serostatuses for <jats:italic>T gondii<\/jats:italic> before undergoing renal transplantation.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s003\">\n<jats:title>PROCEDURES<\/jats:title>\n<jats:p>Medical records of cats that had undergone renal transplantation from 1998 through 2018 were reviewed. Two groups of cats were identified. Before renal transplantation, the SN-UNK group cats were seronegative for <jats:italic>T gondii<\/jats:italic> (n = 4) or serostatus for <jats:italic>T gondii<\/jats:italic> was unknown (4). The SN-UNK group cats received immunosuppressive therapy but were not maintained on prophylactic treatment of <jats:italic>T gondii<\/jats:italic> infection. The SP group cats were seropositive for <jats:italic>T gondii<\/jats:italic> (n = 16) prior to initiation of immunosuppressive therapy and renal transplantation and were managed after surgery with prophylactic treatment of <jats:italic>T gondii<\/jats:italic> infection.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s004\">\n<jats:title>RESULTS<\/jats:title>\n<jats:p>All 8 SN-UNK group cats developed <jats:italic>T gondii<\/jats:italic> infections after initiation of immunosuppressive therapy and renal transplantation; <jats:italic>T gondii<\/jats:italic> infections were fatal in 6 cats. Of 16 SP group cats, 1 developed a nonfatal <jats:italic>T gondii<\/jats:italic> infection resulting in an allograft rejection episode. No SP group cats, which were managed postoperatively with prophylactic treatment, developed a fatal <jats:italic>T gondii<\/jats:italic> infection.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s005\">\n<jats:title>CONCLUSIONS AND CLINICAL RELEVANCE<\/jats:title>\n<jats:p><jats:italic>T gondii<\/jats:italic> infection resulted in morbidity and death in immunosuppressed cats not receiving prophylactic treatment of <jats:italic>T gondii<\/jats:italic> infection after renal transplantation. Seropositive cats were acceptable candidates for renal transplantation when lifelong prophylactic treatment of <jats:italic>T gondii<\/jats:italic> infection was provided.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/javma.258.8.870","type":"journal-article","created":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T13:42:16Z","timestamp":1617802936000},"page":"870-876","source":"Crossref","is-referenced-by-count":6,"title":["Toxoplasma gondii infection in feline renal transplant recipients: 24 cases (1998\u20132018)"],"prefix":"10.2460","volume":"258","author":[{"given":"Hilary C.","family":"Ludwig","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael D.","family":"Schlicksup","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynn M.","family":"Beale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lillian R.","family":"Aronson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"R1","series-title":"J Am Vet Med Assoc","first-page":"1432","article-title":"Renal transplants in cats: 66 cases (1987\u20131996)","volume":"211","author":"Mathews KG","year":"1997","unstructured":"Mathews KG, Gregory CR. 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