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An ivermectin dosing error (intended dose, 0.4 mg\/kg, PO; administered dose, 10 mg\/kg, PO) was retrospectively discovered, and the owner was urged to return the goats for hospitalization and treatment.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s002\">\n<jats:title>Clinical Findings<\/jats:title>\n<jats:p>On admission 19 hours after iatrogenic ivermectin overdose, both goats had tachycardia, tachypnea, and absent menace responses. Goat 1 also had vomited in transit, was lethargic and febrile, had slow pupillary light reflexes, and walked into walls and obstacles. Goat 2 was quiet but responsive, not ataxic or febrile, and had pale mucous membranes and a prolonged capillary refill time.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s003\">\n<jats:title>Treatment and Outcome<\/jats:title>\n<jats:p>Each goat received 20% IV lipid emulsion (2 mL\/kg, IV bolus over 15 minutes, followed by 0.008 mL\/kg\/min, IV) and immediately improved. Activated charcoal was administered by orogastric tube, and 6 hours later, mineral oil was similarly administered. Goat 1 had complete resolution of signs and was discharged by 48 and 72 hours, respectively, after admission. Goat 2 improved but developed progressive respiratory distress after the second orogastric intubation and was euthanized. Necropsy findings were consistent with acute renal tubular necrosis, acute respiratory distress syndrome of unknown cause, ruminal tympany, and mesenteric caseous lymphadenitis.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s004\">\n<jats:title>Clinical Relevance<\/jats:title>\n<jats:p>Results indicated that IV lipid emulsion could be used to successfully treat ivermectin toxicosis in goats. Treatment early in the course of ivermectin toxicosis is advisable to avoid severe clinical signs and secondary complications.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/javma.259.8.914","type":"journal-article","created":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T14:08:36Z","timestamp":1633442916000},"page":"914-918","source":"Crossref","is-referenced-by-count":4,"title":["The use of prolonged administration of low-dose intravenous lipid emulsion to treat ivermectin toxicosis in goats"],"prefix":"10.2460","volume":"259","author":[{"given":"Juan C.","family":"Guerra","sequence":"first","affiliation":[{"name":"From the Department of Clinical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica C.","family":"McKenzie","sequence":"additional","affiliation":[{"name":"From the Department of Clinical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"R1","series-title":"Sheep and goat medicine.","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/B978-1-4377-2353-3.10001-0","article-title":"Handling and examining sheep and goats","author":"Nagy DW","year":"2012","unstructured":"Nagy DW, Pugh DG. 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