{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T18:23:43Z","timestamp":1787336623850,"version":"build-2736575974"},"reference-count":41,"publisher":"American Veterinary Medical Association (AVMA)","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe the frequency and types of gastrointestinal (GI) signs in dogs undergoing ventral slot decompression (VSD) and explore potential risk factors contributing to their development and their clinical impact during hospitalization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective study of dogs diagnosed with cervical intervertebral disk herniation that underwent VSD between 2016 and 2022. Information collected included signalment, neurologic status, medications administered, anesthesia and surgery details, and documented GI signs during hospitalization. Logistic regression evaluated variables potentially predictive of GI complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>126 dogs were included, with a median age of 8 years (range, 1 to 14 years) and median preoperative Modified Frankel score of 2 (range, 0 to 5). Gastrointestinal signs occurred in 29 of 126 dogs (23%), including diarrhea (14 of 29 [48%]), regurgitation (14 of 29 [48%]), hematochezia (5 of 29 [17%]), melena (4 of 29 [14%]), and vomiting (3 of 29 [10%]). Duration of GI signs was 1 to 2 days in 25 of 29 dogs (85%). Age was a predictor of any GI signs (OR, 0.793; 95% CI, 0.659 to 0.942), regurgitation (OR, 0.717; 95% CI, 0.528 to 0.935), and diarrhea (OR, 0.782; 95% CI, 0.605 to 0.987), with younger dogs more likely to develop signs. Perioperative steroid administration was associated with regurgitation (OR, 6.180; 95% CI, 1.159 to 41.879). No other variables were identified as significant predictors. Hospitalization length did not significantly differ between dogs with and without GI signs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>While relatively common, GI complications were self-limiting in most dogs. Younger age and perioperative corticosteroid administration might have increased the odds of development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>Findings have implications for predicting and optimizing perioperative management of GI complications in dogs with cervical intervertebral disk herniation undergoing VSD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2460\/javma.26.01.0021","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:08:03Z","timestamp":1777568883000},"page":"1-9","source":"Crossref","is-referenced-by-count":0,"title":["Gastrointestinal complications occur in dogs with intervertebral disk herniation undergoing ventral slot decompression but are mostly self-limiting"],"prefix":"10.2460","volume":"264","author":[{"given":"Hope M.","family":"Fenton","sequence":"first","affiliation":[{"name":"Angell Animal Medical Center, Boston, MA"},{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim R.","family":"Love","sequence":"additional","affiliation":[{"name":"K. R. Love Quantitative Consulting and Collaboration, Athens, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3829-4193","authenticated-orcid":true,"given":"Melissa J.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN"},{"name":"Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"issue":"5","key":"ref1","series-title":"Vet Clin North Am Small Anim Pract.","first-page":"829","article-title":"Intervertebral disc disease in dogs","volume":"40","author":"Brisson BA","year":"2010","unstructured":"Brisson BA. Intervertebral disc disease in dogs. Vet Clin North Am Small Anim Pract. 2010;40(5):829-858. doi:10.1016\/j.cvsm.2010.06.001"},{"key":"ref2","series-title":"Front Vet Sci.","first-page":"579025","article-title":"Canine Spinal Cord Injury Consortium. Classification of intervertebral disc disease","volume":"7","author":"Fenn J","year":"2020","unstructured":"Fenn J, Olby NJ; Canine Spinal Cord Injury Consortium. Classification of intervertebral disc disease. Front Vet Sci. 2020;7:579025. doi:10.3389\/fvets.2020.579025"},{"issue":"7","key":"ref3","series-title":"Vet Surg.","first-page":"795","article-title":"Acute adverse events associated with ventral slot decompression in 546 dogs with cervical intervertebral disc disease","volume":"42","author":"Rossmeisl JH Jr","year":"2013","unstructured":"Rossmeisl JH Jr, White C, Pancotto TE, Bays A, Henao-Guerrero PN. Acute adverse events associated with ventral slot decompression in 546 dogs with cervical intervertebral disc disease. Vet Surg. 2013;42(7):795-806. doi:10.1111\/j.1532-950X.2013.12039.x"},{"key":"ref4","series-title":"Front Vet Sci.","first-page":"1616461","article-title":"Post-operative complications following cervical ventral slot in dogs: a retrospective review of the influence of prophylactic fenestration and chondrodystrophy in 593 cases","volume":"12","author":"Dupont COC","year":"2025","unstructured":"Dupont COC, Cherubini GB. Post-operative complications following cervical ventral slot in dogs: a retrospective review of the influence of prophylactic fenestration and chondrodystrophy in 593 cases. Front Vet Sci. 2025;12:1616461. doi:10.3389\/fvets.2025.1616461"},{"key":"ref5","series-title":"Front Vet Sci.","first-page":"785228","article-title":"Clinical features and risk factors for gastrointestinal complications in dogs treated surgically for thoracolumbar intervertebral disc extrusion","volume":"8","author":"Mehra JM","year":"2021","unstructured":"Mehra JM, Tolbert MK, Moore GE, Lewis MJ. Clinical features and risk factors for gastrointestinal complications in dogs treated surgically for thoracolumbar intervertebral disc extrusion. Front Vet Sci. 2021;8:785228. doi:10.3389\/fvets.2021.785228"},{"issue":"2","key":"ref6","series-title":"J Vet Intern Med.","first-page":"586","article-title":"Double-blinded placebo-controlled clinical trial of prophylactic omeprazole in dogs treated surgically for acute thoracolumbar intervertebral disc extrusion","volume":"37","author":"Mehra JM","year":"2023","unstructured":"Mehra JM, Tolbert MK, Guadiano P, Steiner JM, Moore GE, Lewis MJ. Double-blinded placebo-controlled clinical trial of prophylactic omeprazole in dogs treated surgically for acute thoracolumbar intervertebral disc extrusion. J Vet Intern Med. 2023;37(2):586-597. doi:10.1111\/jvim.16642"},{"key":"ref7","series-title":"Front Vet Sci.","first-page":"1460092","article-title":"Gut feelings: gastrointestinal signs in French Bulldogs undergoing spinal surgery","volume":"11","author":"du Toit M","year":"2024","unstructured":"du Toit M, Motta L. Gut feelings: gastrointestinal signs in French Bulldogs undergoing spinal surgery. Front Vet Sci. 2024;11:1460092. doi:10.3389\/fvets.2024.1460092"},{"issue":"(10)(suppl)","key":"ref8","series-title":"Spine","first-page":"S522","article-title":"Gastrointestinal complications in spinal cord injury","volume":"16","author":"Albert TJ","year":"1991","unstructured":"Albert TJ, Levine MJ, Balderston RA, Cotler JM. Gastrointestinal complications in spinal cord injury. Spine. 1991;16(10)(suppl):S522\u2013S525. doi:10.1097\/00007632-199110001-00013"},{"key":"ref9","series-title":"Exp Neurol.","first-page":"113009","article-title":"Gastrointestinal dysfunction after spinal cord injury","volume":"320","author":"Holmes GM","year":"2019","unstructured":"Holmes GM, Blanke EN. Gastrointestinal dysfunction after spinal cord injury. Exp Neurol. 2019;320:113009. doi:10.1016\/j.expneurol.2019.113009"},{"key":"ref10","series-title":"Front Physiol","first-page":"277","article-title":"Upper gastrointestinal dysmotility after spinal cord injury: is diminished vagal sensory processing one culprit?","volume":"3","author":"Holmes GM","year":"2012","unstructured":"Holmes GM. Upper gastrointestinal dysmotility after spinal cord injury: is diminished vagal sensory processing one culprit? Front Physiol. 2012;3:277. doi:10.3389\/fphys.2012.00277"},{"key":"ref11","series-title":"Small Animal Spinal Disorders","first-page":"121","article-title":"Thoracolumbar disc disease","author":"Sharp N","year":"2005","unstructured":"Sharp N, Wheeler SJ. Thoracolumbar disc disease. In: Small Animal Spinal Disorders. 2nd ed. Mosby Ltd; 2005:121\u2013159."},{"issue":"4","key":"ref12","series-title":"J Am Vet Med Assoc.","first-page":"385","article-title":"A prospective, randomized, placebo-controlled, double-blinded clinical trial comparing the incidence and severity of gastrointestinal adverse events in dogs with cancer treated with piroxicam alone or in combination with omeprazole or famotidine","volume":"259","author":"Shaevitz MH","year":"2021","unstructured":"Shaevitz MH, Moore GE, Fulkerson CM. A prospective, randomized, placebo-controlled, double-blinded clinical trial comparing the incidence and severity of gastrointestinal adverse events in dogs with cancer treated with piroxicam alone or in combination with omeprazole or famotidine. J Am Vet Med Assoc. 2021;259(4):385-391. doi:10.2460\/javma.259.4.385"},{"issue":"2","key":"ref13","series-title":"Acta Vet Brno.","first-page":"269","article-title":"Complications related to surgical treatment of intervertebral disc disease in dogs","volume":"77","author":"Lexmaulov\u00e1 L","year":"2008","unstructured":"Lexmaulov\u00e1 L, Novotn\u00e1 R, Rau\u0161er P, Ne\u010das A. Complications related to surgical treatment of intervertebral disc disease in dogs. Acta Vet Brno. 2008;77(2):269-276. doi:10.2754\/avb200877020269"},{"issue":"3","key":"ref14","series-title":"J Am Vet Med Assoc.","first-page":"411","article-title":"Adverse effects and outcome associated with dexamethasone administration in dogs with acute thoracolumbar intervertebral disk herniation: 161 cases (2000-2006)","volume":"232","author":"Levine JM","year":"2008","unstructured":"Levine JM, Levine GJ, Boozer L,  Adverse effects and outcome associated with dexamethasone administration in dogs with acute thoracolumbar intervertebral disk herniation: 161 cases (2000-2006). J Am Vet Med Assoc. 2008;232(3):411-417. doi:10.2460\/javma.232.3.411"},{"issue":"4","key":"ref15","series-title":"Acta Vet Brno.","first-page":"361","article-title":"Comparative analysis of neurological recovery and adverse effects in chondrodystrophic dogs with thoracolumbar intervertebral disc herniation treated with methylprednisolone versus non-steroidal anti-inflammatory drugs","volume":"92","author":"McCartney W","year":"2023","unstructured":"McCartney W, Ober CA, Benito M. Comparative analysis of neurological recovery and adverse effects in chondrodystrophic dogs with thoracolumbar intervertebral disc herniation treated with methylprednisolone versus non-steroidal anti-inflammatory drugs. Acta Vet Brno. 2023;92(4):361-368. doi:10.2754\/avb202392040361"},{"issue":"4","key":"ref16","series-title":"J Vet Emerg Crit Care (San Antonio).","first-page":"397","article-title":"Prevalence of and risk factors for intraoperative gastroesophageal reflux and postanesthetic vomiting and diarrhea in dogs undergoing general anesthesia","volume":"27","author":"Torrente C","year":"2017","unstructured":"Torrente C, Vigueras I, Manzanilla EG,  Prevalence of and risk factors for intraoperative gastroesophageal reflux and postanesthetic vomiting and diarrhea in dogs undergoing general anesthesia. J Vet Emerg Crit Care (San Antonio). 2017;27(4):397-408. doi:10.1111\/vec.12613"},{"issue":"20","key":"ref17","series-title":"Vet Rec.","first-page":"513","article-title":"Gastro-oesophageal reflux during anaesthesia in the dog: the effect of age, positioning and type of surgical procedure","volume":"137","author":"Galatos AD","year":"1995","unstructured":"Galatos AD, Raptopoulos D. Gastro-oesophageal reflux during anaesthesia in the dog: the effect of age, positioning and type of surgical procedure. Vet Rec. 1995;137(20):513-516. doi:10.1136\/vr.137.20.513"},{"issue":"3","key":"ref18","series-title":"J Am Vet Med Assoc.","first-page":"327","article-title":"Incidence of and risk factors for postoperative regurgitation and vomiting in dogs: 244 cases (2000-2012)","volume":"246","author":"Davies JA","year":"2015","unstructured":"Davies JA, Fransson BA, Davis AM, Gilbertsen AM, Gay JM. Incidence of and risk factors for postoperative regurgitation and vomiting in dogs: 244 cases (2000-2012). J Am Vet Med Assoc. 2015;246(3):327-335. doi:10.2460\/javma.246.3.327"},{"issue":"5","key":"ref19","series-title":"J Neurosurg Spine.","first-page":"547","article-title":"The impact of automatic retractors on the esophagus during anterior cervical surgery: an experimental in vivo study in a sheep model","volume":"11","author":"Cavu\u015fo\u011flu H","year":"2009","unstructured":"Cavu\u015fo\u011flu H, Tuncer C, Tanik C,  The impact of automatic retractors on the esophagus during anterior cervical surgery: an experimental in vivo study in a sheep model. J Neurosurg Spine. 2009;11(5):547-554. doi:10.3171\/2009.6.SPINE09216"},{"key":"ref20","series-title":"World Neurosurg.","first-page":"275","article-title":"Management of esophageal and pharyngeal perforation as complications of anterior cervical spine surgery","volume":"102","author":"Kang MS","year":"2017","unstructured":"Kang MS, Kim KH, Park JY,  Management of esophageal and pharyngeal perforation as complications of anterior cervical spine surgery. World Neurosurg. 2017;102:275-283. doi:10.1016\/j.wneu.2017.02.130"},{"issue":"3","key":"ref21","series-title":"J Neurosurg Spine.","first-page":"285","article-title":"Esophageal perforation after anterior cervical spine surgery: a systematic review of the literature","volume":"25","author":"Halani SH","year":"2016","unstructured":"Halani SH, Baum GR, Riley JP,  Esophageal perforation after anterior cervical spine surgery: a systematic review of the literature. J Neurosurg Spine. 2016;25(3):285-291. doi:10.3171\/2016.1.SPINE15898"},{"issue":"12","key":"ref22","series-title":"J Am Vet Med Assoc.","first-page":"1","article-title":"Dog Aging Project Consortium. Cross-sectional survey of 43,517 dogs in the Dog Aging Project identifies owner-reported lifetime prevalence and characteristics of gastrointestinal disease","volume":"262","author":"Schmid SM","year":"2024","unstructured":"Schmid SM, Hoffman JM, Gould EN, Moon A, Creevy KE; Dog Aging Project Consortium. Cross-sectional survey of 43,517 dogs in the Dog Aging Project identifies owner-reported lifetime prevalence and characteristics of gastrointestinal disease. J Am Vet Med Assoc. 2024;262(12):1-9. doi:10.2460\/javma.24.05.0306"},{"issue":"3","key":"ref23","series-title":"Vet Anaesth Analg.","first-page":"266","article-title":"The risk of passive regurgitation during general anaesthesia in a population of referred dogs in the UK","volume":"39","author":"Lamata C","year":"2012","unstructured":"Lamata C, Loughton V, Jones M,  The risk of passive regurgitation during general anaesthesia in a population of referred dogs in the UK. Vet Anaesth Analg. 2012;39(3):266-274. doi:10.1111\/j.1467-2995.2011.00704.x"},{"key":"ref24","series-title":"Vet J.","first-page":"106178","article-title":"Thoracolumbar hydrated nucleus pulposus extrusion and intervertebral disc extrusion in dogs: comparison of clinical presentation and magnetic resonance imaging findings","volume":"306","author":"Alcoverro E","year":"2024","unstructured":"Alcoverro E, Schofield I, Spinillo S,  Thoracolumbar hydrated nucleus pulposus extrusion and intervertebral disc extrusion in dogs: comparison of clinical presentation and magnetic resonance imaging findings. Vet J. 2024;306:106178. doi:10.1016\/j.tvjl.2024.106178"},{"issue":"4","key":"ref25","series-title":"Vet Radiol Ultrasound.","first-page":"417","article-title":"Clinical and magnetic resonance imaging characteristics of thoracolumbar intervertebral disk extrusions and protrusions in large breed dogs","volume":"57","author":"Gomes SA","year":"2016","unstructured":"Gomes SA, Volk HA, Packer RMA, Kenny PJ, Beltran E, De Decker S. Clinical and magnetic resonance imaging characteristics of thoracolumbar intervertebral disk extrusions and protrusions in large breed dogs. Vet Radiol Ultrasound. 2016;57(4):417-426. doi:10.1111\/vru.12359"},{"issue":"10","key":"ref26","series-title":"J Small Anim Pract.","first-page":"439","article-title":"Thoracolumbar disc disease in large dogs: a study of 99 cases","volume":"43","author":"Macias C","year":"2002","unstructured":"Macias C, Mckee WM, May C, Innes JF. Thoracolumbar disc disease in large dogs: a study of 99 cases. J Small Anim Pract. 2002;43(10):439-446. doi:10.1111\/j.1748-5827.2002.tb00010.x"},{"issue":"4","key":"ref27","series-title":"Animals (Basel).","first-page":"602","article-title":"Comparison of clinical features of intervertebral disc extrusions in English Cocker Spaniels, French Bulldogs and Dachshunds","volume":"15","author":"Abouzeid J","year":"2025","unstructured":"Abouzeid J, Grapes N, Khan S, De Decker S, Freeman P. Comparison of clinical features of intervertebral disc extrusions in English Cocker Spaniels, French Bulldogs and Dachshunds. Animals (Basel). 2025;15(4):602. doi:10.3390\/ani15040602"},{"issue":"1","key":"ref28","series-title":"Companion Anim Health Genet.","first-page":"9","article-title":"Health status and disease prevalences in French bulldogs in Germany: insights from a survey-based study","volume":"12","author":"Hinze MAG","year":"2025","unstructured":"Hinze MAG, Meyer KOH, Heilmann RM, M\u00fcller U. Health status and disease prevalences in French bulldogs in Germany: insights from a survey-based study. Companion Anim Health Genet. 2025;12(1):9. doi:10.1186\/s40575-025-00149-8"},{"issue":"1","key":"ref29","series-title":"Canine Genet Epidemiol.","first-page":"3","article-title":"Demography and disorders of the French Bulldog population under primary veterinary care in the UK in 2013","volume":"5","author":"O\u2019Neill DG","year":"2018","unstructured":"O\u2019Neill DG, Baral L, Church DB, Brodbelt DC, Packer RMA. Demography and disorders of the French Bulldog population under primary veterinary care in the UK in 2013. Canine Genet Epidemiol. 2018;5(1):3. doi:10.1186\/s40575-018-0057-9"},{"issue":"2","key":"ref30","series-title":"Animals (Basel).","first-page":"234","article-title":"Age-related changes in gut health and behavioral biomarkers in a Beagle dog population","volume":"15","author":"Fern\u00e1ndez-Pinte\u00f1o A","year":"2025","unstructured":"Fern\u00e1ndez-Pinte\u00f1o A, Pilla R, Suchodolski J,  Age-related changes in gut health and behavioral biomarkers in a Beagle dog population. Animals (Basel). 2025;15(2):234. doi:10.3390\/ani15020234"},{"issue":"2","key":"ref31","series-title":"J Am Anim Hosp Assoc.","first-page":"129","article-title":"Complications associated with high-dose prednisolone sodium succinate therapy in dogs with neurological injury","volume":"34","author":"Culbert LA","year":"1998","unstructured":"Culbert LA, Marino DJ, Baule RM, Knox VW III. Complications associated with high-dose prednisolone sodium succinate therapy in dogs with neurological injury. J Am Anim Hosp Assoc. 1998;34(2):129-134. doi:10.5326\/15473317-34-2-129"},{"issue":"2","key":"ref32","series-title":"J Vet Emerg Crit Care (San Antonio).","first-page":"105","article-title":"Complications of methylprednisolone sodium succinate therapy in Dachshunds with surgically treated intervertebral disc disease","volume":"11","author":"Boag AK","year":"2001","unstructured":"Boag AK, Otto CM, Drobatz KJ. Complications of methylprednisolone sodium succinate therapy in Dachshunds with surgically treated intervertebral disc disease. J Vet Emerg Crit Care (San Antonio). 2001;11(2):105-110. doi:10.1111\/j.1476-4431.2001.tb00076.x"},{"issue":"1","key":"ref33","series-title":"J Vet Intern Med.","first-page":"206","article-title":"A placebo-controlled, prospective, randomized clinical trial of polyethylene glycol and methylprednisolone sodium succinate in dogs with intervertebral disk herniation","volume":"30","author":"Olby NJ","year":"2016","unstructured":"Olby NJ, Muguet-Chanoit AC, Lim JH,  A placebo-controlled, prospective, randomized clinical trial of polyethylene glycol and methylprednisolone sodium succinate in dogs with intervertebral disk herniation. J Vet Intern Med. 2016;30(1):206-214. doi:10.1111\/jvim.13657"},{"issue":"1","key":"ref34","series-title":"Anesth Analg.","first-page":"186","article-title":"Dexamethasone for the prevention of postoperative nausea and vomiting: a quantitative systematic review","volume":"90","author":"Henzi I","year":"2000","unstructured":"Henzi I, Walder B, Tram\u00e8r MR. Dexamethasone for the prevention of postoperative nausea and vomiting: a quantitative systematic review. Anesth Analg. 2000;90(1):186-194. doi:10.1097\/00000539-200001000-00038"},{"issue":"8","key":"ref35","series-title":"Am J Vet Res.","first-page":"977","article-title":"Gastric hemorrhage in dogs given high doses of methylprednisolone sodium succinate","volume":"60","author":"Rohrer CR","year":"1999","unstructured":"Rohrer CR, Hill RC, Fischer A,  Gastric hemorrhage in dogs given high doses of methylprednisolone sodium succinate. Am J Vet Res. 1999;60(8):977-981. doi:10.2460\/ajvr.1999.60.08.977"},{"issue":"9","key":"ref36","series-title":"J Vet Med Sci.","first-page":"1103","article-title":"Effect of mosapride on prednisolone-induced gastric mucosal injury and gastric-emptying disorder in dog","volume":"74","author":"Tsukamoto A","year":"2012","unstructured":"Tsukamoto A, Ohno K, Maeda S,  Effect of mosapride on prednisolone-induced gastric mucosal injury and gastric-emptying disorder in dog. J Vet Med Sci. 2012;74(9):1103-1108. doi:10.1292\/jvms.12-0066"},{"issue":"11","key":"ref37","series-title":"Am J Vet Res.","first-page":"1369","article-title":"Endoscopic evaluation of the gastroduodenal mucosa to determine the safety of short-term concurrent administration of meloxicam and dexamethasone in healthy dogs","volume":"64","author":"Boston SE","year":"2003","unstructured":"Boston SE, Moens NMM, Kruth SA, Southorn EP. Endoscopic evaluation of the gastroduodenal mucosa to determine the safety of short-term concurrent administration of meloxicam and dexamethasone in healthy dogs. Am J Vet Res. 2003;64(11):1369-1375. doi:10.2460\/ajvr.2003.64.1369"},{"issue":"5","key":"ref38","series-title":"J Vet Intern Med.","first-page":"1977","article-title":"Clinical, clinicopathologic, and gastrointestinal changes from aspirin, prednisone, or combination treatment in healthy research dogs: a double-blind randomized trial","volume":"33","author":"Whittemore JC","year":"2019","unstructured":"Whittemore JC, Mooney AP, Price JM, Thomason J. Clinical, clinicopathologic, and gastrointestinal changes from aspirin, prednisone, or combination treatment in healthy research dogs: a double-blind randomized trial. J Vet Intern Med. 2019;33(5):1977-1987. doi:10.1111\/jvim.15577"},{"issue":"3","key":"ref39","series-title":"Vet Ther.","first-page":"237","article-title":"Guidelines for safe and effective use of NSAIDs in dogs","volume":"6","author":"Lascelles BD","year":"2005","unstructured":"Lascelles BD, McFarland JM, Swann H. Guidelines for safe and effective use of NSAIDs in dogs. Vet Ther. 2005;6(3):237-251."},{"issue":"4","key":"ref40","series-title":"Vet Ther.","first-page":"263","article-title":"Switching NSAIDs in practice: insights from the Previcox (firocoxib) Experience Trial","volume":"8","author":"Ryan WG","year":"2007","unstructured":"Ryan WG, Moldave K, Carithers D. Switching NSAIDs in practice: insights from the Previcox (firocoxib) Experience Trial. Vet Ther. 2007;8(4):263-271."},{"issue":"6","key":"ref41","series-title":"J Vet Intern Med.","first-page":"1823","article-title":"ACVIM consensus statement: support for rational administration of gastrointestinal protectants to dogs and cats","volume":"32","author":"Marks SL","year":"2018","unstructured":"Marks SL, Kook PH, Papich MG, Tolbert MK, Willard MD. ACVIM consensus statement: support for rational administration of gastrointestinal protectants to dogs and cats. J Vet Intern Med. 2018;32(6):1823-1840. doi:10.1111\/jvim.15337"}],"container-title":["Journal of the American Veterinary Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/264\/9\/javma.26.01.0021.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/264\/9\/javma.26.01.0021.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/264\/9\/javma.26.01.0021.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T17:24:28Z","timestamp":1787333068000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/264\/9\/javma.26.01.0021.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,1]]},"references-count":41,"journal-issue":{"issue":"9"},"URL":"https:\/\/doi.org\/10.2460\/javma.26.01.0021","relation":{},"ISSN":["0003-1488"],"issn-type":[{"value":"0003-1488","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9,1]]}}}