{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T18:23:51Z","timestamp":1787336631935,"version":"build-2736575974"},"reference-count":50,"publisher":"American Veterinary Medical Association (AVMA)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the efficacy of lorazepam in reducing the rate of recurrence in first-time feline urethral obstruction (UO) and frequency of lower urinary tract (LUT) signs following hospitalization, as well as adverse effects of the medication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a prospective, randomized, double-blinded, placebo-controlled study of 80 client-owned male cats presenting to a university teaching hospital with UO between 2021 and 2025. Cats with urolithiasis or urinary tract infection were excluded. Cats received lorazepam or placebo for 1 month after hospitalization for UO.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>41 cats received lorazepam and 39 cats received placebo. Seventy-two cats completed the study. Five of 72 cats experienced recurrence of UO, all receiving placebo. No cats receiving lorazepam had UO recurrence (0%; 95% CI, 0.0% to 10.9%) compared to the placebo group (15.7%; 95% CI, 5.2% to 33.7%); this was statistically significant. There was a statistically significant reduction in LUT signs for 2 of 33 cats during days 8 to 15 (95% CI, 0.7% to 20.2%) and 1 of 31 cats during days 16 to 30 (95% CI, 0.1% to 16.7%) for the lorazepam group. Ataxia was the only statistically significant side effect of lorazepam, occurring in 4 of 31 cats (13%); other reported effects included sedation, increased appetite, and vocalization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Lorazepam administration was associated with a reduction in the recurrence of UO in this study population, as well as reduced LUT signs compared to cats receiving placebo. Lorazepam administration was found to be safe.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>Lorazepam may be used safely in the reduction of both recurrent UO and LUT signs following alleviation of UO in male cats.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2460\/javma.26.01.0045","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T15:53:28Z","timestamp":1778082808000},"page":"1143-1151","source":"Crossref","is-referenced-by-count":0,"title":["Lorazepam reduces recurrence of urethral obstruction in male cats: a prospective, randomized, double-blinded, placebo-controlled study"],"prefix":"10.2460","volume":"264","author":[{"given":"Alexa","family":"Splittstoesser","sequence":"first","affiliation":[{"name":"Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Kerley","sequence":"additional","affiliation":[{"name":"Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jody","family":"Lulich","sequence":"additional","affiliation":[{"name":"Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Randall","sequence":"additional","affiliation":[{"name":"Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Tart","sequence":"additional","affiliation":[{"name":"Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"issue":"12","key":"ref1","series-title":"J Small Anim Pract","first-page":"571","article-title":"Evaluation of clinical signs and causes of lower urinary tract disease in European cats","volume":"46","author":"Gerber B","year":"2005","unstructured":"Gerber B, Boretti FS, Kley S,  Evaluation of clinical signs and causes of lower urinary tract disease in European cats. 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