{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:18:14Z","timestamp":1787750294514,"version":"build-2784847793"},"reference-count":17,"publisher":"American Veterinary Medical Association (AVMA)","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2026,8,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the prevalence of increased 1,2-O-dilauryl-rac-glycero glutaric acid-(6\u2019-methylresorufin) ester (DGGR) lipase activity in cats with and without pancreatitis, and to evaluate its diagnostic performance relative to a clinical diagnosis of pancreatitis and ultrasonographic assessments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Serum DGGR lipase activity was measured with the Randox lipase assay and considered increased if &gt; 25 U\/L. A board-certified internal medicine clinician, blinded to DGGR results, gave each cat a clinician-assigned score from 0 (no pancreatitis) to 4 (definite pancreatitis). Ultrasonographic scores (0 to 4) were assigned on the basis of the number of changes supportive of pancreatitis. DGGR lipase performance was compared with clinical and ultrasonographic scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 231 cats were included; 59 of 231 (25.5%) had increased DGGR lipase activity. Clinical scores were 0 in 47 of 231 cats (20.3%), 1 in 128 of 231 (55.4%), 2 in 36 of 231 (15.6%), and 3 in 20 of 231 (8.7%); no cats had a score of 4. With the use of a clinical score of 3 as the reference, DGGR lipase activity had a sensitivity of 70% and specificity of 79% (positive predictive value, 24%; negative predictive value, 97%). DGGR lipase activity was significantly lower in cats with an ultrasound score of 0 compared to scores of 1, 2, and 3. DGGR lipase activity was lower in cats with clinician-assigned scores of 0 and 1 compared to scores of 2 and 3.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>DGGR lipase activity was lower in cats with lower clinical and ultrasonographic scores and demonstrated a high negative predictive value.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>In this low-prevalence referral population, a normal DGGR lipase result reduced the likelihood of clinician-suspected pancreatitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2460\/javma.26.01.0064","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T12:21:08Z","timestamp":1787746868000},"page":"1-7","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic performance of 1,2-O-dilauryl-rac-glycero glutaric acid-(6\u2019-methylresorufin) ester lipase activity in cats presenting to a veterinary referral hospital"],"prefix":"10.2460","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4196-3401","authenticated-orcid":true,"given":"Javier","family":"Rodriguez Godoy","sequence":"first","affiliation":[{"name":"The Ralph Veterinary Referral Centre, Marlow, Buckinghamshire, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7940-5478","authenticated-orcid":true,"given":"Annelies","family":"Willems","sequence":"additional","affiliation":[{"name":"The Ralph Veterinary Referral Centre, Marlow, Buckinghamshire, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9736-4729","authenticated-orcid":true,"given":"Patricia","family":"Ibarrola","sequence":"additional","affiliation":[{"name":"The Ralph Veterinary Referral Centre, Marlow, Buckinghamshire, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0477-1780","authenticated-orcid":true,"given":"Mark","family":"Rishniw","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY"},{"name":"Veterinary Information Network, Davis, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"issue":"1","key":"ref1","series-title":"J Small Anim Pract","first-page":"13","article-title":"Diagnosis of pancreatitis in dogs and cats","volume":"56","author":"Xenoulis PG","year":"2015","unstructured":"Xenoulis PG. Diagnosis of pancreatitis in dogs and cats. J Small Anim Pract. 2015;56(1):13-26. doi:10.1111\/jsap.12274"},{"issue":"2","key":"ref2","series-title":"J Vet Intern Med","first-page":"703","article-title":"ACVIM consensus statement on pancreatitis in cats","volume":"35","author":"Forman MA","year":"2021","unstructured":"Forman MA, Steiner JM, Armstrong PJ,  ACVIM consensus statement on pancreatitis in cats. J Vet Intern Med. 2021;35(2):703-723. doi:10.1111\/jvim.16053"},{"issue":"5","key":"ref3","series-title":"J Vet Intern Med","first-page":"1077","article-title":"Agreement of the serum Spec fPL\u2122 and 1,2-o-dilauryl-rac-glycero-3-glutaric acid-(6\u2032-methylresorufin) ester lipase assay for the determination of serum lipase in cats with suspicion of pancreatitis","volume":"27","author":"Oppliger S","year":"2013","unstructured":"Oppliger S, Hartnack S, Riond B, Reusch CE, Kook PH. 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Vet Sci. 2023;10(3):209. doi:10.3390\/vetsci10030209"}],"container-title":["Journal of the American Veterinary Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/aop\/javma.26.01.0064\/javma.26.01.0064.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/aop\/javma.26.01.0064\/javma.26.01.0064.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T12:21:08Z","timestamp":1787746868000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/aop\/javma.26.01.0064\/javma.26.01.0064.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,26]]},"references-count":17,"URL":"https:\/\/doi.org\/10.2460\/javma.26.01.0064","relation":{},"ISSN":["0003-1488"],"issn-type":[{"value":"0003-1488","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8,26]]}}}