{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:51:32Z","timestamp":1792173092245,"version":"4.4.0"},"reference-count":22,"publisher":"American Veterinary Medical Association (AVMA)","issue":"11","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2026,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To retrospectively evaluate the clinical efficacy and safety of the canine parvovirus monoclonal antibody (CPMA) administered with standardized supportive care for naturally occurring canine parvovirus (CPV) in a shelter setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Electronic medical records from CPV-positive dogs treated at Gigi\u2019s Parvovirus Treatment Center between June 2020 and May 2024 were reviewed. All dogs received a standardized standard-of-care (SOC) algorithm. Dogs treated prior to August 2023 received SOC alone (n = 49), while those admitted thereafter received CPMA (0.2 mL\/kg, IV) plus SOC (63). Primary outcomes were hospitalization duration, mortality, and time to isolation release criteria (2 consecutive negative CPV ELISA tests [SNAP; Idexx Laboratories Inc]). Secondary outcomes included modified clinical severity scores, medication scores, and total cost of care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Dogs receiving CPMA with SOC had significantly shorter hospitalization (median, 2 vs 4 days) and reached isolation release criteria sooner (median, 5 vs 6.5 days) compared with SOC alone. Mortality did not differ significantly (17% vs 22%). Maximum medication scores and overall cost of care were not statistically different, although CPMA-treated dogs showed a real-world median cost reduction of $978.50. One CPMA-treated dog experienced an anaphylactic reaction and recovered with supportive care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CPMA administration in combination with SOC accelerated clinical recovery and time to release from isolation compared with SOC alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>CPMA appears clinically effective and safe for naturally occurring CPV infections in a shelter environment. By reducing isolation time, CPMA may improve welfare, reduce behavioral risk associated with prolonged isolation and medical trauma, and support earlier adoption.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2460\/javma.26.04.0291","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T17:10:43Z","timestamp":1784740243000},"page":"1-9","source":"Crossref","is-referenced-by-count":0,"title":["Retrospective evaluation of canine parvovirus monoclonal antibody supports faster clinical recovery in shelter dogs with naturally occurring canine parvovirus"],"prefix":"10.2460","volume":"264","author":[{"given":"Molly","family":"Welton","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH"},{"name":"The Comparative Hepatobiliary and Intestinal Research Program, College of Veterinary Medicine, The Ohio State University, Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayley","family":"Hadden","sequence":"additional","affiliation":[{"name":"Gigi\u2019s, Canal Winchester, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan","family":"Herron","sequence":"additional","affiliation":[{"name":"Gigi\u2019s, Canal Winchester, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenessa A.","family":"Winston","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH"},{"name":"The Comparative Hepatobiliary and Intestinal Research Program, College of Veterinary Medicine, The Ohio State University, Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Vet Med (Auckl)","first-page":"91","article-title":"Canine parvoviral enteritis: an update on the clinical diagnosis, treatment, and prevention","volume":"7","author":"Mylonakis ME","year":"2016","unstructured":"Mylonakis ME, Kalli I, Rallis TS. 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