{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T16:42:37Z","timestamp":1787330557834,"version":"build-2736575974"},"reference-count":44,"publisher":"American Veterinary Medical Association (AVMA)","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2026,8,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To understand veterinary practitioner awareness about Rocky Mountain spotted fever (RMSF) and their receptivity and clients\u2019 perceived receptivity to a vaccine to protect dogs from RMSF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The survey tool was developed in collaboration with the CDC and AVMA. Responses were collected June 9, 2025, through July 1, 2025. Respondents were surveyed on whether they had ever diagnosed a case of RMSF and their confidence in identifying the symptoms of RMSF, receptivity to a canine RMSF or anti-tick vaccine, and clients\u2019 perceived receptivity to a vaccine. We calculated survey-weighted estimates for the companion- and mixed-animal practitioner population for proportions (95% CIs) and multinomial logistic regression to compute ORs (95% CIs) for comparisons of interest. Free-text responses to questions on vaccines were also collected for educational purposes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eligible respondents included 731 (91.3%) companion-animal practitioners and 70 (8.7%) mixed-animal practitioners. The odds of practitioners recommending a vaccine who felt very confident in recognizing symptoms were 3.9 (95% CI, 3.1 to 4.9) times that of those who felt not confident at all. Fifty-four percent (95% CI, 50% to 58%) of practitioners\u2019 clients would be interested in a canine RMSF vaccine, and 79% (95% CI, 76% to 82%) of practitioners were interested in a combined anti-tick vaccine. Vaccine interest was not limited to a single geographic or practice environment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A potential market for a canine RMSF vaccine and a more general combined anti-tick vaccine exists across geographic regions and practice environments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>Vaccine receptivity and patient care could be improved through education about RMSF and vaccine technology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2460\/javma.26.05.0342","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T16:12:01Z","timestamp":1787328721000},"page":"1-9","source":"Crossref","is-referenced-by-count":0,"title":["Survey of veterinarians\u2019 receptivity to a canine vaccine for Rocky Mountain spotted fever reveals a potential vaccine market and opportunities for education"],"prefix":"10.2460","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3739-4506","authenticated-orcid":true,"given":"Tori S.","family":"Moore","sequence":"first","affiliation":[{"name":"Rickettsial Zoonoses Branch, Division of Vector-Borne Diseases, CDC, Fort Collins, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Pikel","sequence":"additional","affiliation":[{"name":"AVMA, Schaumburg, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalanthe","family":"Horiuchi","sequence":"additional","affiliation":[{"name":"Office of the Director, Division of Vector-Borne Diseases, CDC, Fort Collins, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad J.","family":"Biggerstaff","sequence":"additional","affiliation":[{"name":"Office of the Director, Division of Vector-Borne Diseases, CDC, Fort Collins, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen K.","family":"Brophy","sequence":"additional","affiliation":[{"name":"Rickettsial Zoonoses Branch, Division of Vector-Borne Diseases, CDC, Fort Collins, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Carpenter","sequence":"additional","affiliation":[{"name":"Rickettsial Zoonoses Branch, Division of Vector-Borne Diseases, CDC, Fort Collins, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dharati","family":"Szymanski","sequence":"additional","affiliation":[{"name":"AVMA, Schaumburg, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna S.","family":"Salzer","sequence":"additional","affiliation":[{"name":"Rickettsial Zoonoses Branch, Division of Vector-Borne Diseases, CDC, Fort Collins, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"issue":"RR-4","key":"ref1","series-title":"MMWR Recomm Rep","first-page":"1","article-title":"CDC. Diagnosis and management of tickborne rickettsial diseases: Rocky Mountain spotted fever, ehrlichioses, and anaplasmosis--United States: a practical guide for physicians and other health-care and public health professionals","volume":"55","author":"Chapman AS","year":"2006","unstructured":"Chapman AS, Bakken JS, Folk SM, ; CDC. Diagnosis and management of tickborne rickettsial diseases: Rocky Mountain spotted fever, ehrlichioses, and anaplasmosis--United States: a practical guide for physicians and other health-care and public health professionals. MMWR Recomm Rep. 2006;55(RR-4):1-27."},{"key":"ref2","series-title":"UpToDate","article-title":"Epidemiology, clinical manifestations, and diagnosis of Rocky Mountain spotted fever","author":"McClain MT","unstructured":"McClain MT. Epidemiology, clinical manifestations, and diagnosis of Rocky Mountain spotted fever. UpToDate. Updated December 16, 2024. Accessed March 20, 2026. https:\/\/www.uptodate.com\/contents\/epidemiology-clinical-manifestations-and-diagnosis-of-rocky-mountain-spotted-fever"},{"issue":"6","key":"ref3","series-title":"J Infect Dis","first-page":"911","article-title":"Pathogenesis of infection with Rickettsia rickettsii in the dog: a disease model for Rocky Mountain spotted fever","volume":"135","author":"Keenan KP","year":"1977","unstructured":"Keenan KP, Buhles WC Jr, Huxsoll DL  Pathogenesis of infection with Rickettsia rickettsii in the dog: a disease model for Rocky Mountain spotted fever. J Infect Dis. 1977;135(6):911-917. doi:10.1093\/infdis\/135.6.911"},{"issue":"10 pt 1","key":"ref4","series-title":"J Am Vet Med Assoc","first-page":"994","article-title":"Rocky Mountain spotted fever in dogs","volume":"176","author":"Lissman BA","year":"1980","unstructured":"Lissman BA, Benach JL. Rocky Mountain spotted fever in dogs. J Am Vet Med Assoc. 1980;176(10 pt 1):994-995. doi:10.2460\/javma.1980.176.10.994"},{"issue":"10","key":"ref5","series-title":"Am J Vet Res","first-page":"2124","article-title":"Canine Rocky Mountain spotted fever: a kennel epizootic","volume":"46","author":"Breitschwerdt EB","year":"1985","unstructured":"Breitschwerdt EB, Meuten DJ, Walker DH,  Canine Rocky Mountain spotted fever: a kennel epizootic. Am J Vet Res. 1985;46(10):2124-2128. doi:10.2460\/ajvr.1985.46.10.2124"},{"key":"ref6","series-title":"Merck Veterinary Manual","article-title":"Rocky Mountain spotted fever in dogs","author":"Palerme JS","unstructured":"Palerme JS. Rocky Mountain spotted fever in dogs. Merck Veterinary Manual. Updated September 2025. Accessed March 13, 2026. https:\/\/www.merckvetmanual.com\/infectious-diseases\/rickettsial-diseases-in-dogs\/rocky-mountain-spotted-fever-in-dogs"},{"issue":"10","key":"ref7","series-title":"Open Forum Infect Dis","first-page":"ofac506","article-title":"Morbidity and functional outcomes following Rocky Mountain spotted fever hospitalization-Arizona, 2002-2017","volume":"9","author":"Drexler NA","year":"2022","unstructured":"Drexler NA, Close R, Yaglom HD,  Morbidity and functional outcomes following Rocky Mountain spotted fever hospitalization-Arizona, 2002-2017. Open Forum Infect Dis. 2022;9(10):ofac506. doi:10.1093\/ofid\/ofac506"},{"issue":"3","key":"ref8","series-title":"Am J Vet Res","article-title":"A wolf at the door: the ecology, epidemiology, and emergence of community- and urban-level Rocky Mountain spotted fever in the Americas","volume":"86","author":"Foley J","year":"2025","unstructured":"Foley J, L\u00f3pez-P\u00e9rez AM, \u00c1lvarez-Hern\u00e1ndez G,  A wolf at the door: the ecology, epidemiology, and emergence of community- and urban-level Rocky Mountain spotted fever in the Americas. Am J Vet Res. 2025;86(3):ajvr.24.11.0368. doi:10.2460\/ajvr.24.11.0368"},{"key":"ref9","article-title":"Where ticks live","author":"CDC","year":"2024","unstructured":"CDC. Where ticks live. May 15, 2024. Updated July 30, 2025. Accessed January 24, 2026. https:\/\/www.cdc.gov\/ticks\/about\/where-ticks-live.html"},{"issue":"6","key":"ref10","series-title":"N Engl J Med","first-page":"587","article-title":"Rocky Mountain spotted fever from an unexpected tick vector in Arizona","volume":"353","author":"Demma LJ","year":"2005","unstructured":"Demma LJ, Traeger MS, Nicholson WL,  Rocky Mountain spotted fever from an unexpected tick vector in Arizona. N Engl J Med. 2005;353(6):587-594. doi:10.1056\/NEJMoa050043"},{"key":"ref11","series-title":"Parasit Vectors","first-page":"26","article-title":"Biology and ecology of the brown dog tick, Rhipicephalus sanguineus","volume":"3","author":"Dantas-Torres F","year":"2010","unstructured":"Dantas-Torres F. Biology and ecology of the brown dog tick, Rhipicephalus sanguineus. Parasit Vectors. 2010;3:26. doi:10.1186\/1756-3305-3-26"},{"issue":"1","key":"ref12","series-title":"Am J Trop Med Hyg","first-page":"156","article-title":"Ecologic risk factors for infestation of Rhipicephalus sanguineus s.l. in a Rocky Mountain spotted fever-endemic area of eastern Arizona","volume":"113","author":"Brophy MK","year":"2025","unstructured":"Brophy MK, Drexler NA, Stone NE,  Ecologic risk factors for infestation of Rhipicephalus sanguineus s.l. in a Rocky Mountain spotted fever-endemic area of eastern Arizona. Am J Trop Med Hyg. 2025;113(1):156-162. doi:10.4269\/ajtmh.24-0485"},{"issue":"11","key":"ref13","series-title":"Emerg Infect Dis","first-page":"2231","article-title":"Conceptual framework for community-based prevention of brown dog tick-associated Rocky Mountain spotted fever","volume":"30","author":"Brophy MK","year":"2024","unstructured":"Brophy MK, Weis E, Drexler NA,  Conceptual framework for community-based prevention of brown dog tick-associated Rocky Mountain spotted fever. Emerg Infect Dis. 2024;30(11):2231-2240. doi:10.3201\/eid3011.240293"},{"key":"ref14","article-title":"Arizona Rocky Mountain spotted fever handbook","author":"Arizona Department of Health Services","year":"2020","unstructured":"Arizona Department of Health Services. Arizona Rocky Mountain spotted fever handbook. February 10, 2020. Updated July 2025. Accessed April 2, 2026. https:\/\/www.azdhs.gov\/documents\/preparedness\/epidemiology-disease-control\/rocky-mountain-spotted-fever\/rmsf-handbook.pdf"},{"issue":"5","key":"ref15","series-title":"Am J Trop Med Hyg","first-page":"1070","article-title":"Rocky Mountain spotted fever in Mexico: a call to action","volume":"111","author":"\u00c1lvarez-Hern\u00e1ndez G","year":"2024","unstructured":"\u00c1lvarez-Hern\u00e1ndez G, L\u00f3pez-Ridaura R, Cort\u00e9s-Alcal\u00e1 R,  Rocky Mountain spotted fever in Mexico: a call to action. Am J Trop Med Hyg. 2024;111(5):1070-1077. doi:10.4269\/ajtmh.24-0265"},{"issue":"6","key":"ref16","series-title":"Lancet Infect Dis","first-page":"e189","article-title":"Rocky Mountain spotted fever in Mexico: past, present, and future","volume":"17","author":"\u00c1lvarez-Hern\u00e1ndez G","year":"2017","unstructured":"\u00c1lvarez-Hern\u00e1ndez G, Rold\u00e1n JFG, Milan NSH, Lash RR, Behravesh CB, Paddock CD. Rocky Mountain spotted fever in Mexico: past, present, and future. Lancet Infect Dis. 2017;17(6):e189-e196. doi:10.1016\/S1473-3099(17)30173-1"},{"issue":"46","key":"ref17","series-title":"MMWR Morb Mortal Wkly Rep","first-page":"1302","article-title":"Notes from the field: community-based prevention of Rocky Mountain spotted fever - Sonora, Mexico, 2016","volume":"65","author":"Straily A","year":"2016","unstructured":"Straily A, Drexler N, Cruz-Loustaunau D, Paddock CD, Alvarez-Hernandez G. Notes from the field: community-based prevention of Rocky Mountain spotted fever - Sonora, Mexico, 2016. MMWR Morb Mortal Wkly Rep. 2016;65(46):1302-1303. doi:10.15585\/mmwr.mm6546a6"},{"issue":"10","key":"ref18","series-title":"Vaccines (Basel)","first-page":"1626","article-title":"A vaccine for canine Rocky Mountain spotted fever: an unmet One Health need","volume":"10","author":"Walker DH","year":"2022","unstructured":"Walker DH, Blanton LS, Laroche M, Fang R, Narra HP. A vaccine for canine Rocky Mountain spotted fever: an unmet One Health need. Vaccines (Basel). 2022;10(10):1626. doi:10.3390\/vaccines10101626"},{"issue":"12","key":"ref19","series-title":"PLoS One","first-page":"e112368","article-title":"Community-based control of the brown dog tick in a region with high rates of Rocky Mountain spotted fever, 2012-2013","volume":"9","author":"Drexler N","year":"2014","unstructured":"Drexler N, Miller M, Gerding J,  Community-based control of the brown dog tick in a region with high rates of Rocky Mountain spotted fever, 2012-2013. PLoS One. 2014;9(12):e112368. doi:10.1371\/journal.pone.0112368"},{"issue":"4","key":"ref20","series-title":"Ticks Tick Borne Dis","first-page":"102344","article-title":"A mutation associated with resistance to synthetic pyrethroids is widespread in US populations of the tropical lineage of Rhipicephalus sanguineus s.l","volume":"15","author":"Stone NE","year":"2024","unstructured":"Stone NE, Ballard R, Bourgeois RM,  A mutation associated with resistance to synthetic pyrethroids is widespread in US populations of the tropical lineage of Rhipicephalus sanguineus s.l. Ticks Tick Borne Dis. 2024;15(4):102344. doi:10.1016\/j.ttbdis.2024.102344"},{"issue":"41","key":"ref21","series-title":"Public Health Rep","first-page":"2159","article-title":"Rocky Mountain spotted fever: vaccination of monkeys and man","volume":"40","author":"Spencer RR","year":"1925","unstructured":"Spencer RR, Parker RR. Rocky Mountain spotted fever: vaccination of monkeys and man. Public Health Rep. 1925;40(41):2159-2167. doi:10.2307\/4577679"},{"issue":"3","key":"ref22","series-title":"Am J Trop Med Hyg","first-page":"369","article-title":"Rocky Mountain spotted fever: results of fifteen years\u2019 prophylactic vaccination","volume":"21","author":"Parker RR","year":"1941","unstructured":"Parker RR. Rocky Mountain spotted fever: results of fifteen years\u2019 prophylactic vaccination. Am J Trop Med Hyg. 1941;21(3):369-383. doi:10.4269\/ajtmh.1941.s1-21.369"},{"issue":"1","key":"ref23","series-title":"J Infect Dis","first-page":"78","article-title":"Rocky Mountain spotted fever: results of ten years\u2019 prophylactic vaccination","volume":"57","author":"Parker RR","year":"1935","unstructured":"Parker RR. Rocky Mountain spotted fever: results of ten years\u2019 prophylactic vaccination. J Infect Dis. 1935;57(1):78-93."},{"issue":"6","key":"ref24","series-title":"J Clin Microbiol","first-page":"500","article-title":"Preparation of Rocky Mountain spotted fever vaccine suitable for human immunization","volume":"1","author":"Kenyon RH","year":"1975","unstructured":"Kenyon RH, Pedersen CE Jr. Preparation of Rocky Mountain spotted fever vaccine suitable for human immunization. J Clin Microbiol. 1975;1(6):500-503. doi:10.1128\/jcm.1.6.500-503.1975"},{"issue":"5","key":"ref25","series-title":"J Infect Dis","first-page":"922","article-title":"Reactogenicity, immunogenicity, and efficacy of a chick embryo cell-derived vaccine for Rocky Mountain spotted fever","volume":"14","author":"Clements ML","year":"1983","unstructured":"Clements ML, Wisseman CL Jr, Woodward TE,  Reactogenicity, immunogenicity, and efficacy of a chick embryo cell-derived vaccine for Rocky Mountain spotted fever. J Infect Dis. 1983;14(5):922-930. doi:10.1093\/infdis\/148.5.922"},{"issue":"3","key":"ref26","series-title":"Infect Immun","first-page":"646","article-title":"A recombinant Rickettsia conorii vaccine protects guinea pigs from experimental boutonneuse fever and Rocky Mountain spotted fever","volume":"58","author":"Vishwanath S","year":"1990","unstructured":"Vishwanath S, McDonald GA, Watkins NG. A recombinant Rickettsia conorii vaccine protects guinea pigs from experimental boutonneuse fever and Rocky Mountain spotted fever. Infect Immun. 1990;58(3):646-653. doi:10.1128\/iai.58.3.646-653.1990"},{"issue":"25-26","key":"ref27","series-title":"Vaccine","first-page":"3901","article-title":"Cross-protection between distantly related spotted fever group rickettsiae","volume":"21","author":"Feng HM","year":"2003","unstructured":"Feng HM, Walker DH. Cross-protection between distantly related spotted fever group rickettsiae. Vaccine. 2003;21(25-26):3901-3905. doi:10.1016\/S0264-410X(03)00301-3"},{"issue":"4784","key":"ref28","series-title":"Science","first-page":"83","article-title":"Cloned gene of Rickettsia rickettsii surface antigen: candidate vaccine for Rocky Mountain spotted fever","volume":"235","author":"McDonald GA","year":"1987","unstructured":"McDonald GA, Anacker RL, Garjian K. Cloned gene of Rickettsia rickettsii surface antigen: candidate vaccine for Rocky Mountain spotted fever. Science. 1987;235(4784):83-85. doi:10.1126\/science.3099387"},{"issue":"1","key":"ref29","series-title":"Vaccine","first-page":"29","article-title":"Protection of guinea-pigs from experimental Rocky Mountain spotted fever by immunization with baculovirus-expressed Rickettsia rickettsii rOmpA protein","volume":"13","author":"Sumner JW","year":"1995","unstructured":"Sumner JW, Sims KG, Jones DC, Anderson BE. Protection of guinea-pigs from experimental Rocky Mountain spotted fever by immunization with baculovirus-expressed Rickettsia rickettsii rOmpA protein. Vaccine. 1995;13(1):29-35. doi:10.1016\/0264-410X(95)80007-Z"},{"issue":"9","key":"ref30","series-title":"Pathog Dis","first-page":"ftv101","article-title":"Failure of a heterologous recombinant Sca5\/OmpB protein-based vaccine to elicit effective protective immunity against Rickettsia rickettsii infections in C3H\/HeN mice","volume":"73","author":"Riley SP","year":"2015","unstructured":"Riley SP, Cardwell MM, Chan YG, Pruneau L, Del Piero F, Martinez JJ. Failure of a heterologous recombinant Sca5\/OmpB protein-based vaccine to elicit effective protective immunity against Rickettsia rickettsii infections in C3H\/HeN mice. Pathog Dis. 2015;73(9):ftv101. doi:10.1093\/femspd\/ftv101"},{"issue":"10","key":"ref31","series-title":"Infect Immun","first-page":"2587","article-title":"Protective monoclonal antibodies recognize heat-labile epitopes on surface proteins of spotted fever group rickettsiae","volume":"56","author":"Li H","year":"1988","unstructured":"Li H, Lenz B, Walker DH. Protective monoclonal antibodies recognize heat-labile epitopes on surface proteins of spotted fever group rickettsiae. Infect Immun. 1988;56(10):2587-2593. doi:10.1128\/iai.56.10.2587-2593.1988"},{"issue":"11","key":"ref32","series-title":"J Immunol","first-page":"5314","article-title":"Role of T lymphocyte subsets in immunity to spotted fever group Rickettsiae","volume":"158","author":"Feng H","year":"1997","unstructured":"Feng H, Popov VL, Yuoh G, Walker DH. Role of T lymphocyte subsets in immunity to spotted fever group Rickettsiae. J Immunol. 1997;158(11):5314-5320. doi:10.4049\/jimmunol.158.11.5314"},{"issue":"18","key":"ref33","series-title":"Vaccine","first-page":"2027","article-title":"Surface protein Adr2 of Rickettsia rickettsii induced protective immunity against Rocky Mountain spotted fever in C3H\/HeN mice","volume":"32","author":"Gong W","year":"2014","unstructured":"Gong W, Xiong X, Qi Y, Jiao J, Duan C, Wen B. Surface protein Adr2 of Rickettsia rickettsii induced protective immunity against Rocky Mountain spotted fever in C3H\/HeN mice. Vaccine. 2014;32(18):2027-2033. doi:10.1016\/j.vaccine.2014.02.057"},{"issue":"8","key":"ref34","series-title":"Vaccine","first-page":"985","article-title":"Enhanced protection against Rickettsia rickettsii infection in C3H\/HeN mice by immunization with a combination of a recombinant adhesin rAdr2 and a protein fragment rOmpB-4 derived from outer membrane protein B","volume":"33","author":"Gong W","year":"2015","unstructured":"Gong W, Wang P, Xiong X, Jiao J, Yang X, Wen B. Enhanced protection against Rickettsia rickettsii infection in C3H\/HeN mice by immunization with a combination of a recombinant adhesin rAdr2 and a protein fragment rOmpB-4 derived from outer membrane protein B. Vaccine. 2015;33(8):985-992. doi:10.1016\/j.vaccine.2015.01.017"},{"issue":"2","key":"ref35","series-title":"Infect Immun","first-page":"e00628","article-title":"Rickettsia ricketsii whole-cell antigens offer protection against Rocky Mountain spotted fever in the canine host","volume":"87","author":"Alhassan A","year":"2019","unstructured":"Alhassan A, Liu H, McGill J,  Rickettsia ricketsii whole-cell antigens offer protection against Rocky Mountain spotted fever in the canine host. Infect Immun. 2019;87(2):e00628-18. doi:10.1128\/IAI.00628-18"},{"issue":"11","key":"ref36","series-title":"Vector Borne Zoonotic Dis","first-page":"579","article-title":"Effects of Rickettsia amblyommatis infection on the vector competence of Amblyomma americanum ticks for Rickettsia rickettsii","volume":"18","author":"Levin ML","year":"2018","unstructured":"Levin ML, Schumacher LBM, Snellgrove A. Effects of Rickettsia amblyommatis infection on the vector competence of Amblyomma americanum ticks for Rickettsia rickettsii. Vector Borne Zoonotic Dis. 2018;18(11):579-587. doi:10.1089\/vbz.2018.2284"},{"issue":"7","key":"ref37","series-title":"Pathogens","first-page":"819","article-title":"Rickettsia parkeri with a genetically disrupted phage integrase gene exhibits attenuated virulence and induces protective immunity against fatal rickettsioses in mice","volume":"10","author":"Arroyave E","year":"2021","unstructured":"Arroyave E, Hyseni I, Burkhardt N,  Rickettsia parkeri with a genetically disrupted phage integrase gene exhibits attenuated virulence and induces protective immunity against fatal rickettsioses in mice. Pathogens. 2021;10(7):819. doi:10.3390\/pathogens10070819"},{"issue":"5722","key":"ref38","series-title":"Nature","first-page":"491","article-title":"Immunisation of guinea pigs and cattle against ticks","volume":"280","author":"Allen JR","year":"1979","unstructured":"Allen JR, Humphreys SJ. Immunisation of guinea pigs and cattle against ticks. Nature. 1979;280(5722):491-493. doi:10.1038\/280491a0"},{"issue":"2-4","key":"ref39","series-title":"Vet Parasitol","first-page":"321","article-title":"Efficacy of the Bm86 antigen against immature instars and adults of the dog tick Rhipicephalus sanguineus (Latreille, 1806) (Acari: Ixodidae)","volume":"167","author":"Perez-Perez D","year":"2010","unstructured":"Perez-Perez D, Bechara GH, Machado RZ,  Efficacy of the Bm86 antigen against immature instars and adults of the dog tick Rhipicephalus sanguineus (Latreille, 1806) (Acari: Ixodidae). Vet Parasitol. 2010;167(2-4):321-326. doi:10.1016\/j.vetpar.2009.09.034"},{"issue":"10","key":"ref40","series-title":"Vaccine","first-page":"1782","article-title":"A novel tick antigen shows high vaccine efficacy against the dog tick, Rhipicephalus sanguineus","volume":"30","author":"Rodr\u00edguez-Mallon A","year":"2012","unstructured":"Rodr\u00edguez-Mallon A, Fern\u00e1ndez E, Encinosa PE,  A novel tick antigen shows high vaccine efficacy against the dog tick, Rhipicephalus sanguineus. Vaccine. 2012;30(10):1782-1789. doi:10.1016\/j.vaccine.2012.01.011"},{"key":"ref41","series-title":"Modern Applied Statistics with S","author":"Venables WN","year":"2002","unstructured":"Venables WN, Ripley BD. Modern Applied Statistics with S. 4th ed. Springer; 2002. doi:10.1007\/978-0-387-21706-2"},{"key":"ref42","series-title":"Complex Surveys: A Guide to Analysis Using R","author":"Lumley T","year":"2010","unstructured":"Lumley T. Complex Surveys: A Guide to Analysis Using R. John Wiley and Sons; 2010. doi:10.1002\/9780470580066"},{"key":"ref43","series-title":"svyVGAM: Design-Based Inference in Vector Generalised Linear Models","year":"2026","unstructured":"svyVGAM: Design-Based Inference in Vector Generalised Linear Models. Version 1.3. The R Foundation; 2026. doi:10.32614\/CRAN.package.svyVGAM"},{"issue":"3","key":"ref44","series-title":"Biom J","first-page":"346","article-title":"Simultaneous inference in general parametric models","volume":"50","author":"Hothorn T","year":"2008","unstructured":"Hothorn T, Bretz F, Westfall P. Simultaneous inference in general parametric models. Biom J. 2008;50(3):346-363. doi:10.1002\/bimj.200810425"}],"container-title":["Journal of the American Veterinary Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/aop\/javma.26.05.0342\/javma.26.05.0342.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/aop\/javma.26.05.0342\/javma.26.05.0342.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T16:12:01Z","timestamp":1787328721000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/aop\/javma.26.05.0342\/javma.26.05.0342.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,21]]},"references-count":44,"URL":"https:\/\/doi.org\/10.2460\/javma.26.05.0342","relation":{},"ISSN":["0003-1488"],"issn-type":[{"value":"0003-1488","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8,21]]}}}