{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:01:25Z","timestamp":1790780485045,"version":"4.1.0"},"reference-count":15,"publisher":"American Veterinary Medical Association (AVMA)","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2026,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Canine Lyme borreliosis is commonly treated with a 28-day course of doxycycline, a regimen based on historical precedent rather than evidence. Most dogs exposed to\n                    <jats:italic>Borrelia burgdorferi<\/jats:italic>\n                    remain clinically normal despite seroconversion; of those that do develop clinical Lyme disease, the most common presentation is acute or recurrent shifting-leg lameness consistent with Lyme arthropathy. This Viewpoint proposes there is clinical equipoise to evaluate shorter durations of 10 days of doxycycline in dogs with uncomplicated Lyme arthropathy and outlines a prospective parallel-group randomized controlled trial to reassess treatment duration. Determining whether a shorter treatment course is clinically effective also has important implications for antimicrobial stewardship by minimizing unnecessary antimicrobial exposure and selection pressures for antimicrobial resistance.\n                  <\/jats:p>","DOI":"10.2460\/javma.26.07.0602","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:49:19Z","timestamp":1790779759000},"page":"1-4","source":"Crossref","is-referenced-by-count":0,"title":["Is 28 days of doxycycline still justified for canine Lyme arthropathy? A call for a randomized controlled trial"],"prefix":"10.2460","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3549-0551","authenticated-orcid":true,"given":"Fiona","family":"Emdin","sequence":"first","affiliation":[{"name":"Public Health Ontario, Toronto, ON, Canada"},{"name":"Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada"},{"name":"Global Strategy Lab, York University, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Daneman","sequence":"additional","affiliation":[{"name":"Public Health Ontario, Toronto, ON, Canada"},{"name":"Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada"},{"name":"Division of Infectious Diseases, Sunnybrook Health Sciences Centre, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1896-1937","authenticated-orcid":true,"given":"J. Scott","family":"Weese","sequence":"additional","affiliation":[{"name":"Ontario Veterinary College, University of Guelph, Guelph, ON, Canada"},{"name":"Centre for Public Health and Zoonoses, University of Guelph, Guelph, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"issue":"1","key":"ref1","series-title":"Am J Vet Res","first-page":"49","article-title":"Use of tick surveys and serosurveys to evaluate pet dogs as a sentinel species for emerging Lyme disease","volume":"70","author":"Hamer SA","year":"2009","unstructured":"Hamer SA, Tsao JI, Walker ED, Mansfield LS, Foster ES, Hickling GJ. Use of tick surveys and serosurveys to evaluate pet dogs as a sentinel species for emerging Lyme disease. Am J Vet Res. 2009;70(1):49-56. doi:10.2460\/ajvr.70.1.49"},{"issue":"3","key":"ref2","series-title":"J Am Vet Med Assoc","first-page":"344","article-title":"Relationship between development of antibodies to Borrelia burgdorferi in dogs and the subsequent development of limb\/joint borreliosis","volume":"200","author":"Levy SA","year":"1992","unstructured":"Levy SA, Magnarelli LA. Relationship between development of antibodies to Borrelia burgdorferi in dogs and the subsequent development of limb\/joint borreliosis. J Am Vet Med Assoc. 1992;200(3):344-347. doi:10.2460\/javma.1992.200.03.344"},{"issue":"3","key":"ref3","series-title":"J Vet Intern Med","first-page":"887","article-title":"ACVIM consensus update on Lyme borreliosis in dogs and cats","volume":"32","author":"Littman MP","year":"2018","unstructured":"Littman MP, Gerber B, Goldstein RE, Labato MA, Lappin MR, Moore GE. ACVIM consensus update on Lyme borreliosis in dogs and cats. 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NAVC Clin Brief. 2007;5(5):9-12."}],"container-title":["Journal of the American Veterinary Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/aop\/javma.26.07.0602\/javma.26.07.0602.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/aop\/javma.26.07.0602\/javma.26.07.0602.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:49:19Z","timestamp":1790779759000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/aop\/javma.26.07.0602\/javma.26.07.0602.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,30]]},"references-count":15,"URL":"https:\/\/doi.org\/10.2460\/javma.26.07.0602","relation":{},"ISSN":["0003-1488"],"issn-type":[{"value":"0003-1488","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9,30]]}}}