{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:06:39Z","timestamp":1792098399413,"version":"4.4.0"},"reference-count":28,"publisher":"Japanese Society for Magnetic Resonance in Medicine","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MRMS","magn reson med sci"],"published-print":{"date-parts":[[2016]]},"DOI":"10.2463\/mrms.2015-0012","type":"journal-article","created":{"date-parts":[[2015,9,3]],"date-time":"2015-09-03T22:06:40Z","timestamp":1441318000000},"page":"111-120","source":"Crossref","is-referenced-by-count":14,"title":["Significance of the Signal Intensity of Gadoxetic Acid-enhanced MR Imaging for Predicting the Efficacy of Hepatic Arterial Infusion Chemotherapy in Hepatocellular Carcinoma"],"prefix":"10.2463","volume":"15","author":[{"given":"Nobuhiro","family":"FUJITA","sequence":"first","affiliation":[{"name":"Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"NISHIE","sequence":"additional","affiliation":[{"name":"Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"ASAYAMA","sequence":"additional","affiliation":[{"name":"Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kousei","family":"ISHIGAMI","sequence":"additional","affiliation":[{"name":"Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"USHIJIMA","sequence":"additional","affiliation":[{"name":"Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihisa","family":"TAKAYAMA","sequence":"additional","affiliation":[{"name":"Department of Radiology Informatics and Network, Graduate School of Medical Sciences, Kyushu University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"OKAMOTO","sequence":"additional","affiliation":[{"name":"Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"MORITA","sequence":"additional","affiliation":[{"name":"Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"SHIRABE","sequence":"additional","affiliation":[{"name":"Department of Surgery and Sciences, Graduate School of Medical Sciences, Kyushu University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"KOTO","sequence":"additional","affiliation":[{"name":"Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichiro","family":"KUBO","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinao","family":"ODA","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"HONDA","sequence":"additional","affiliation":[{"name":"Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1295","reference":[{"key":"1","doi-asserted-by":"publisher","unstructured":"1. Huppertz A, Balzer T, Blakeborough A, et al. Improved detection of focal liver lesions at MR imaging: multicenter comparison of gadoxetic acid-enhanced MR images with intraoperative findings. Radiology 2004; 230:266\u2013275.","DOI":"10.1148\/radiol.2301020269"},{"key":"2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1148\/radiology.200.1.8657946","volume":"200","author":"TJ Vogl","year":"1996","unstructured":"2. Vogl TJ, K\u00fcmmel S, Hammerstingl R, et al. Liver tumors: comparison of MR imaging with Gd-EOB-DTPA and Gd-DTPA. Radiology 1996; 200:59\u201367.","journal-title":"Radiology","ISSN":"https:\/\/id.crossref.org\/issn\/0033-8419","issn-type":"print"},{"key":"3","doi-asserted-by":"publisher","unstructured":"3. Ahn SS, Kim MJ, Lim JS, Hong HS, Chung YE, Choi JY. Added value of gadoxetic acid-enhanced hepatobiliary phase MR imaging in the diagnosis of hepatocellular carcinoma. Radiology 2010; 255:459\u2013466.","DOI":"10.1148\/radiol.10091388"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Golfieri R, Renzulli M, Lucidi V, Corcioni B, Trevisani F, Bolondi L. Contribution of the hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI to dynamic MRI in the detection of hypovascular small (\u2264 2 cm) HCC in cirrhosis. Eur Radiol 2011; 21:1233\u20131242.","DOI":"10.1007\/s00330-010-2030-1"},{"key":"5","doi-asserted-by":"publisher","unstructured":"5. Kitao A, Zen Y, Matsui O, et al. Hepatocellular carcinoma: signal intensity at gadoxetic acid-enhanced MR Imaging--correlation with molecular transporters and histopathologic features. Radiology 2010; 256:817\u2013826.","DOI":"10.1148\/radiol.10092214"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Narita M, Hatano E, Arizono S, et al. Expression of OATP1B3 determines uptake of Gd-EOB-DTPA in hepatocellular carcinoma. J Gastroenterol 2009; 44:793\u2013798.","DOI":"10.1007\/s00535-009-0056-4"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Asayama Y, Tajima T, Nishie A, et al. Uptake of Gd-EOB-DTPA by hepatocellular carcinoma: radiologic-pathologic correlation with special reference to bile production. Eur J Radiol 2011; 80:e243\u2013e248.","DOI":"10.1016\/j.ejrad.2010.10.032"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Yamashita T, Kitao A, Matsui O, et al. Gd-EOB-DTPA-enhanced magnetic resonance imaging and alpha-fetoprotein predict prognosis of early-stage hepatocellular carcinoma. Hepatology 2014; 60:1674\u20131685.","DOI":"10.1002\/hep.27093"},{"key":"9","doi-asserted-by":"publisher","unstructured":"9. Choi JW, Lee JM, Kim SJ, et al. Hepatocellular carcinoma: imaging patterns on gadoxetic acid-enhanced MR images and their value as an imaging biomarker. Radiology 2013; 267:776\u2013786.","DOI":"10.1148\/radiol.13120775"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Choi JY, Kim MJ, Park YN, et al. Gadoxetate disodium-enhanced hepatobiliary phase MRI of hepatocellular carcinoma: correlation with histological characteristics. AJR Am J Roentgenol 2011; 197:399\u2013405.","DOI":"10.2214\/AJR.10.5439"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Kim JY, Kim MJ, Kim KA, Jeong HT, Park YN. Hyperintense HCC on hepatobiliary phase images of gadoxetic acid-enhanced MRI: correlation with clinical and pathological features. Eur J Radiol 2012; 81:3877\u20133882.","DOI":"10.1016\/j.ejrad.2012.07.021"},{"key":"12","doi-asserted-by":"publisher","unstructured":"12. Kitao A, Matsui O, Yoneda N, et al. Hypervascular hepatocellular carcinoma: correlation between biologic features and signal intensity on gadoxetic acid-enhanced MR images. Radiology 2012; 265:780\u2013789.","DOI":"10.1148\/radiol.12120226"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Fujita N, Nishie A, Kubo Y, et al. Hepatocellular carcinoma: clinical significance of signal heterogeneity in the hepatobiliary phase of gadoxetic acid-enhanced MR imaging. Eur Radiol 2015; 25:211\u2013220.","DOI":"10.1007\/s00330-014-3349-9"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Ishimaru H, Nakashima K, Sakugawa T, et al. Local recurrence after chemoembolization of hepatocellular carcinoma: uptake of gadoxetic acid as a new prognostic factor. AJR Am J Roentgenol 2014; 202:744\u2013751.","DOI":"10.2214\/AJR.13.10848"},{"key":"15","doi-asserted-by":"publisher","unstructured":"15. Ando E, Tanaka M, Yamashita F, et al. Hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma with portal vein tumor thrombosis: analysis of 48 cases. Cancer 2002; 95:588\u2013595.","DOI":"10.1002\/cncr.10694"},{"key":"16","doi-asserted-by":"publisher","unstructured":"16. Ando E, Yamashita F, Tanaka M, Tanikawa K. A novel chemotherapy for advanced hepatocellular carcinoma with tumor thrombosis of the main trunk of the portal vein. Cancer 1997; 79:1890\u20131896.","DOI":"10.1002\/(SICI)1097-0142(19970515)79:10<1890::AID-CNCR8>3.0.CO;2-K"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Arii S, Sata M, Sakamoto M, et al. Management of hepatocellular carcinoma: Report of Consensus Meeting in the 45th Annual Meeting of the Japan Society of Hepatology (2009). Hepatol Res 2010; 40:667\u2013685.","DOI":"10.1111\/j.1872-034X.2010.00673.x"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Yamasaki T, Kimura T, Kurokawa F, et al. Prognostic factors in patients with advanced hepatocellular carcinoma receiving hepatic arterial infusion chemotherapy. J Gastroenterol 2005; 40:70\u201378.","DOI":"10.1007\/s00535-004-1494-7"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Nishie A, Kakihara D, Asayama Y, et al. Detectability of hepatocellular carcinoma on gadoxetic acid-enhanced MRI at 3 T in patients with severe liver dysfunction: clinical impact of dual-source parallel radiofrequency excitation. Clin Radiol 2015; 70:254\u2013261.","DOI":"10.1016\/j.crad.2014.11.006"},{"key":"20","first-page":"862","volume":"52","author":"S Tanaka","year":"2005","unstructured":"20. Tanaka S, Shimada M, Shirabe K, et al. A novel intrahepatic arterial chemotherapy after radical resection for advanced hepatocellular carcinoma. Hepatogastroenterology 2005; 52:862\u2013865.","journal-title":"Hepatogastroenterology","ISSN":"https:\/\/id.crossref.org\/issn\/0172-6390","issn-type":"print"},{"key":"21","doi-asserted-by":"publisher","unstructured":"21. International Working Party. Terminology of nodular hepatocellular lesions. Hepatology 1995; 22:983\u2013993.","DOI":"10.1016\/0270-9139(95)90324-0"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Crestani M, De Fabiani E, Caruso D, et al. LXR (liver X receptor) and HNF-4 (hepatocyte nuclear factor-4): key regulators in reverse cholesterol transport. Biochem Soc Trans 2004; 32(Pt 1):92\u201396.","DOI":"10.1042\/bst0320092"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Bonzo JA, Ferry CH, Matsubara T, Kim JH, Gonzalez FJ. Suppression of hepatocyte proliferation by hepatocyte nuclear factor 4alpha in adult mice. J Biol Chem 2012; 287:7345\u20137356.","DOI":"10.1074\/jbc.M111.334599"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Ning BF, Ding J, Yin C, et al. Hepatocyte nuclear factor 4 alpha suppresses the development of hepatocellular carcinoma. Cancer Res 2010; 70:7640\u20137651.","DOI":"10.1158\/0008-5472.CAN-10-0824"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Yin C, Lin Y, Zhang X, et al. Differentiation therapy of hepatocellular carcinoma in mice with recombinant adenovirus carrying hepatocyte nuclear factor-4alpha gene. Hepatology 2008; 48:1528\u20131539.","DOI":"10.1002\/hep.22510"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Koo CY, Muir KW, Lam EW. FOXM1: from cancer initiation to progression and treatment. Biochim Biophys Acta 2012; 1819:28\u201337.","DOI":"10.1016\/j.bbagrm.2011.09.004"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Kitao A, Matsui O, Yoneda N, et al. The uptake transporter OATP8 expression decreases during multistep hepatocarcinogenesis: correlation with gadoxetic acid enhanced MR imaging. Eur Radiol 2011; 21:2056\u20132066.","DOI":"10.1007\/s00330-011-2165-8"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Nishie A, Asayama Y, Ishigami K, et al. MR prediction of liver fibrosis using a liver-specific contrast agent: superparamagnetic iron oxide versus Gd-EOB-DTPA. J Magn Reson Imaging 2012; 36:664\u2013671.","DOI":"10.1002\/jmri.23691"}],"container-title":["Magnetic Resonance in Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/mrms\/15\/1\/15_2015-0012\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T05:10:03Z","timestamp":1567141803000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/mrms\/15\/1\/15_2015-0012\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.2463\/mrms.2015-0012","relation":{},"ISSN":["1347-3182","1880-2206"],"issn-type":[{"value":"1347-3182","type":"print"},{"value":"1880-2206","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}