{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:41:15Z","timestamp":1761864075667},"reference-count":34,"publisher":"Japanese Society for Magnetic Resonance in Medicine","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MRMS","magn reson med sci"],"published-print":{"date-parts":[[2021]]},"DOI":"10.2463\/mrms.mp.2019-0153","type":"journal-article","created":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T22:15:15Z","timestamp":1582064115000},"page":"20-27","source":"Crossref","is-referenced-by-count":11,"title":["Microcystic, Elongated and Fragmented Pattern Invasion Can Adversely Influence Preoperative Staging for Low-grade Endometrial Carcinoma"],"prefix":"10.2463","volume":"20","author":[{"given":"Ryo","family":"Kuwahara","sequence":"first","affiliation":[{"name":"Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aki","family":"Kido","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Yajima","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Nishio","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoko","family":"Nakao","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhisa","family":"Kurata","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiro","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Clinical Biostatistics, Kyoto University Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachiko","family":"Minamiguchi","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology, Kyoto University Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsukasa","family":"Baba","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Iwate Medical University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Mandai","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaori","family":"Togashi","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1295","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Morice P, Leary A, Creutzberg C, Abu-Rustum N, Darai E. Endometrial cancer. Lancet 2016; 387:1094\u20131108.","DOI":"10.1016\/S0140-6736(15)00130-0"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Salvesen HB, Haldorsen IS, Trovik J. Markers for individualised therapy in endometrial carcinoma. Lancet Oncol 2012; 13:e353\u2013e361.","DOI":"10.1016\/S1470-2045(12)70213-9"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Pecorelli S. Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. Int J Gynaecol Obstet 2009; 105:103\u2013104.","DOI":"10.1016\/j.ijgo.2009.02.012"},{"key":"4","unstructured":"4. Union internationale contre le cancer (UICC). TNM: Classification des tumeurs malignes, 7th ed. New York, NY: Wiley-Blackwell; 2009."},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Bendifallah S, Dara\u00ef E, Ballester M. Predictive modeling: a new paradigm for managing endometrial cancer. Ann Surg Oncol 2016; 23:975\u2013988.","DOI":"10.1245\/s10434-015-4924-2"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Murray SK, Young RH, Scully RE. Unusual epithelial and stromal changes in myoinvasive endometrioid adenocarcinoma: a study of their frequency, associated diagnostic problems, and prognostic significance. Int J Gynecol Pathol 2003; 22:324\u2013333.","DOI":"10.1097\/01.pgp.0000092161.33490.a9"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Pavlakis K, Messini I, Vrekoussis T, et al. MELF invasion in endometrial cancer as a risk factor for lymph node metastasis. Histopathology 2011; 58:966\u2013973.","DOI":"10.1111\/j.1365-2559.2011.03802.x"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Stewart CJ, Brennan BA, Leung YC, Little L. MELF pattern invasion in endometrial carcinoma: association with low grade, myoinvasive endometrioid tumours, focal mucinous differentiation and vascular invasion. Pathology 2009; 41:454\u2013459.","DOI":"10.1080\/00313020903041135"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Joehlin-Price AS, McHugh KE, Stephens JA, et al. The microcystic, elongated, and fragmented (MELF) pattern of invasion: a single institution report of 464 consecutive FIGO grade 1 endometrial endometrioid adenocarcinomas. Am J Surg Pathol 2017; 41:49\u201355.","DOI":"10.1097\/PAS.0000000000000754"},{"key":"10","unstructured":"10. Mariani A, Webb MJ, Keeney GL, Haddock MG, Calori G, Podratz KC. Low-risk corpus cancer: is lymphadenectomy or radiotherapy necessary? Am J Obstet Gynecol 2000; 182:1506\u20131519."},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Lee KB, Ki KD, Lee JM, et al. The risk of lymph node metastasis based on myometrial invasion and tumor grade in endometrioid uterine cancers: a multicenter, retrospective Korean study. Ann Surg Oncol 2009; 16:2882\u20132887.","DOI":"10.1245\/s10434-009-0535-0"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Colombo N, Creutzberg C, Amant F, et al. ESMO-ESGO-ESTRO consensus conference on endometrial cancer: diagnosis, treatment and follow-up. Int J Gynecol Cancer 2016; 26:2\u201330.","DOI":"10.1097\/IGC.0000000000000609"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Manfredi R, Gui B, Maresca G, Fanfani F, Bonomo L. Endometrial cancer: magnetic resonance imaging. Abdom Imaging 2005; 30:626\u2013636.","DOI":"10.1007\/s00261-004-0298-9"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Atri M, Zhang Z, Dehdashti F, et al. Utility of PET\/CT to evaluate retroperitoneal lymph node metastasis in high-risk endometrial cancer: results of ACRIN 6671\/GOG 0233 trial. Radiology 2017; 283:450\u2013459.","DOI":"10.1148\/radiol.2016160200"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Beddy P, Moyle P, Kataoka M, et al. Evaluation of depth of myometrial invasion and overall staging in endometrial cancer: comparison of diffusion-weighted and dynamic contrast-enhanced MR imaging. Radiology 2012; 262:530\u2013537.","DOI":"10.1148\/radiol.11110984"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Kinkel K. Pitfalls in staging uterine neoplasm with imaging: a review. Abdom Imaging 2006; 31:164\u2013173.","DOI":"10.1007\/s00261-005-0383-8"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Landis JR, Koch GG. The measurement of observer agreement for categorical data. Biometrics 1977; 33:159\u2013174.","DOI":"10.2307\/2529310"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Manfredi R, Mirk P, Maresca G, et al. Local-regional staging of endometrial carcinoma: role of MR imaging in surgical planning. Radiology 2004; 231:372\u2013378.","DOI":"10.1148\/radiol.2312021184"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Rockall AG, Sohaib SA, Harisinghani MG, et al. Diagnostic performance of nanoparticle-enhanced magnetic resonance imaging in the diagnosis of lymph node metastases in patients with endometrial and cervical cancer. J Clin Oncol 2005; 23:2813\u20132821.","DOI":"10.1200\/JCO.2005.07.166"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Sugiyama T, Nishida T, Ushijima K, et al. Detection of lymph node metastasis in ovarian carcinoma and uterine corpus carcinoma by preoperative computerized tomography or magnetic resonance imaging. J Obstet Gynaecol (Tokyo 1995) 1995; 21:551\u2013556.","DOI":"10.1111\/j.1447-0756.1995.tb00911.x"},{"key":"21","unstructured":"21. Connor JP, Andrews JI, Anderson B, Buller RE. Computed tomography in endometrial carcinoma. Obstet Gynecol 2000; 95:692\u2013696."},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Pelletier MP, Trinh VQ, Stephenson P, et al. Microcystic, elongated, and fragmented pattern invasion is mainly associated with isolated tumor cell pattern metastases in International Federation of Gynecology and Obstetrics grade I endometrioid endometrial cancer. Hum Pathol 2017; 62:33\u201339.","DOI":"10.1016\/j.humpath.2016.10.023"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Han G, Lim D, Leitao MM, Abu-Rustum NR, Soslow RA. Histological features associated with occult lymph node metastasis in FIGO clinical stage I, grade I endometrioid carcinoma. Histopathology 2014; 64:389\u2013398.","DOI":"10.1111\/his.12254"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Bollineni VR, Ytre-Hauge S, Bollineni-Balabay O, Salvesen HB, Haldorsen IS. High diagnostic value of 18F-FDG PET\/CT in endometrial cancer: systematic review and meta-analysis of the literature. J Nucl Med 2016; 57:879\u2013885.","DOI":"10.2967\/jnumed.115.170597"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Kitajima K, Murakami K, Yamasaki E, et al. Accuracy of 18F-FDG PET\/CT in detecting pelvic and paraaortic lymph node metastasis in patients with endometrial cancer. AJR Am J Roentgenol 2008; 190:1652\u20131658.","DOI":"10.2214\/AJR.07.3372"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Sundaram M, McGuire MH, Schajowicz F. Soft-tissue masses: histologic basis for decreased signal (short T2) on T2-weighted MR images. AJR Am J Roentgenol 1987; 148:1247\u20131250.","DOI":"10.2214\/ajr.148.6.1247"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Eriksson LSE, Nastic D, Fr\u00fchauf F, et al. Clinical and ultrasound characteristics of the microcystic elongated and fragmented (MELF) pattern in endometrial cancer according to the International Endometrial Tumor Analysis (IETA) criteria. Int J Gynecol Cancer 2019; 29:119\u2013125.","DOI":"10.1136\/ijgc-2018-000045"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Zamani F, Goodarzi S, Hallaji F, et al. Diagnostic value of pelvic MRI for assessment of the depth of myometrial invasion and cervical involvement in endometrial cancer: comparison of new versus old FIGO staging. Iran J Radiol 2012; 9:202\u2013208.","DOI":"10.5812\/iranjradiol.5276"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Nougaret S, Reinhold C, Alsharif SS, et al. Endometrial cancer: combined MR volumetry and diffusion-weighted imaging for assessment of myometrial and lymphovascular invasion and tumor grade. Radiology 2015; 276:797\u2013808.","DOI":"10.1148\/radiol.15141212"},{"key":"30","unstructured":"30. Bonatti M, Stuefer J, Oberhofer N, et al. MRI for local staging of endometrial carcinoma: Is endovenous contrast medium administration still needed? Eur J Radiol 2015; 84:208\u2013214."},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Gallego JC, Porta A, Pardo MC, Fern\u00e1ndez C. Evaluation of myometrial invasion in endometrial cancer: comparison of diffusion-weighted magnetic resonance and intraoperative frozen sections. Abdom Imaging 2014; 39:1021\u20131026.","DOI":"10.1007\/s00261-014-0134-9"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Andreano A, Rechichi G, Rebora P, Sironi S, Valsecchi MG, Galimberti S. MR diffusion imaging for preoperative staging of myometrial invasion in patients with endometrial cancer: a systematic review and meta-analysis. Eur Radiol 2014; 24:1327\u20131338.","DOI":"10.1007\/s00330-014-3139-4"},{"key":"33","unstructured":"33. Wu LM, Xu JR, Gu HY, Hua J, Haacke EM, Hu J. Predictive value of T2-weighted imaging and contrast-enhanced MR imaging in assessing myometrial invasion in endometrial cancer: a pooled analysis of prospective studies. Eur Radiol 2012; 23:435\u2013449."},{"key":"34","unstructured":"34. Soneji ND, Bharwani N, Ferri A, Stewart V, Rockall A. Pre-operative MRI staging of endometrial cancer in a multicentre cancer network: can we match single centre study results? Eur Radiol 2018; 28:4725\u20134734."}],"container-title":["Magnetic Resonance in Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/mrms\/20\/1\/20_mp.2019-0153\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,6]],"date-time":"2021-03-06T04:00:47Z","timestamp":1615003247000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/mrms\/20\/1\/20_mp.2019-0153\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.2463\/mrms.mp.2019-0153","relation":{},"ISSN":["1347-3182","1880-2206"],"issn-type":[{"value":"1347-3182","type":"print"},{"value":"1880-2206","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}