{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T20:26:16Z","timestamp":1780518376376,"version":"3.54.1"},"reference-count":28,"publisher":"Japanese Society for Magnetic Resonance in Medicine","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MRMS","magn reson med sci"],"published-print":{"date-parts":[[2026]]},"DOI":"10.2463\/mrms.mp.2025-0068","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:08:25Z","timestamp":1760134105000},"page":"n\/a","source":"Crossref","is-referenced-by-count":2,"title":["Labyrinthine Signal Intensity on Non\u2013contrast-enhanced 3D\u2013real Inversion Recovery MR Imaging: Correlation with the Endolymphatic Volume Measured on Contrast-enhanced HYDROPS-Mi2"],"prefix":"10.2463","volume":"25","author":[{"given":"Toshio","family":"Ohashi","sequence":"first","affiliation":[{"name":"Department of Radiology, Kamiiida Daiichi General Hospital, Nagoya Aichi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Naganawa","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya Aichi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Radiology, Kamiiida Daiichi General Hospital, Nagoya Aichi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayao","family":"Kuno","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Kamiiida Daiichi General Hospital, Naogya Aichi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1295","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Nakashima T, Pyykk\u00f6 I, Arroll MA, et al. Meniere\u2019s disease. Nat Rev Dis Primers 2016; 2:16028.","DOI":"10.1038\/nrdp.2016.28"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Naganawa S, Nakashima T. Visualization of endolymphatic hydrops with MR imaging in patients with M\u00e9ni\u00e8re\u2019s disease and related pathologies: Current status of its methods and clinical significance. Jpn J Radiol 2014; 32:191\u2013204.","DOI":"10.1007\/s11604-014-0290-4"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Naganawa S. The technical and clinical ceatures of 3D-FLAIR in neuroimaging. Magn Reson Med Sci 2015; 14:93\u2013106.","DOI":"10.2463\/mrms.2014-0132"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Naganawa S, Komada T, Fukatsu H, Ishigaki T, Takizawa O. Observation of contrast enhancement in the cochlear fluid space of healthy subjects using a 3D-FLAIR sequence at 3 Tesla. Eur Radiol 2006; 16:733\u2013737.","DOI":"10.1007\/s00330-005-0046-8"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Nakashima T, Naganawa S, Teranishi M, et al. Endolymphatic hydrops revealed by intravenous gadolinium injection in patients with M\u00e9ni\u00e8re\u2019s disease. Acta Otolaryngol 2010; 130:338\u2013343.","DOI":"10.3109\/00016480903143986"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Naganawa S, Kawai H, Sone M, Nakashima T. Increased sensitivity to low concentration gadolinium contrast by optimized heavily T2-weighted 3D-FLAIR to visualize endolymphatic space. Magn Reson Med Sci 2010; 9:73\u201380.","DOI":"10.2463\/mrms.9.73"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Naganawa S, Yamazaki M, Kawai H, Bokura K, Sone M, Nakashima T. Visualization of endolymphatic hydrops in M\u00e9ni\u00e8re\u2019s disease with single-dose intravenous gadolinium-based contrast media using heavily T2-weighted 3D-FLAIR. Magn Reson Med Sci 2010; 9:237\u2013242.","DOI":"10.2463\/mrms.9.237"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Naganawa S, Kawai H, Taoka T, Sone M. Improved 3D\u2013real inversion recovery: A robust imaging technique for endolymphatic hydrops after intravenous administration of gadolinium. Magn Reson Med Sci 2019; 18:105\u2013108.","DOI":"10.2463\/mrms.bc.2017-0158"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Ohashi T, Naganawa S, Takeuchi A, Katagiri T, Kuno K. Quantification of endolymphatic space volume after intravenous administration of a single dose of gadolinium-based contrast agent: 3D\u2013real inversion recovery versus HYDROPS-Mi2. Magn Reson Med Sci 2020; 19:119\u2013124.","DOI":"10.2463\/mrms.mp.2019-0013"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Simon F, Guichard JP, Kania R, Franc J, Herman P, Hautefort C. Saccular measurements in routine MRI can predict hydrops in Meni\u00e8re\u2019s disease. Eur Arch Otorhinolaryngol 2017; 274:4113\u20134120.","DOI":"10.1007\/s00405-017-4756-8"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Venkatasamy A, Veillon F, Fleury A, et al. Imaging of the saccule for the diagnosis of endolymphatic hydrops in Meniere disease, using a three-dimensional T2-weighted steady state free precession sequence: Accurate, fast, and without contrast material intravenous injection. Eur Radiol Exp 2017; 1:14.","DOI":"10.1186\/s41747-017-0020-7"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Keller JH Hirsch BE, Marovich RS, Branstetter BF 4th. Detection of endolymphatic hydrops using traditional MR imaging sequences. Am J Otolaryngol 2017; 38:442\u2013446.","DOI":"10.1016\/j.amjoto.2017.01.038"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Naganawa S, Sone M. Letter to Editors: Detection of endolymphatic hydrops using traditional MR imaging sequences. Am J Otolaryngol 2017; 38:637\u2013638.","DOI":"10.1016\/j.amjoto.2017.06.014"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Dominguez P, Naganawa S. Letter to the editor on the article \u201cSaccular measurements in routine MRI can predict hydrops in M\u00e9ni\u00e8re\u2019s disease\u201d by Simon F, et al. Eur Arch Otorhinolaryngol 2018; 275:311\u2013312.","DOI":"10.1007\/s00405-017-4794-2"},{"key":"15","unstructured":"15. Ohashi T, Naganawa S, Nasu Y, Kuno K, Kato K. Magnetic resonance imaging of endolymphatic hydrops: A comparison of methods with and without gadolinium-based contrast agent administration. Nagoya J Med Sci 2023; 85:299\u2013309."},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Fukutomi H, Hamitouche L, Yamamoto T, et al. Visualization of the saccule and utricle with non\u2013contrast-enhanced FLAIR sequences. Eur Radiol 2022; 32:3532\u20133540.","DOI":"10.1007\/s00330-021-08403-w"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Kato Y, Naganawa S, Taoka T, Yoshida T, Sone M. Pitfalls of using T2-contrast enhancement techniques in 3D-FLAIR to detect endolymphatic hydrops. Magn Reson Med Sci 2023; 22:335\u2013344.","DOI":"10.2463\/mrms.mp.2022-0017"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Ishii M, Tanaka H, Asai R, et al. New non\u2013contrast MRI of endolymphatic hydrops in M\u00e9ni\u00e8re\u2019s disease considering inversion time. Laryngoscope Investig Otolaryngol 2024; 9:e1314.","DOI":"10.1002\/lio2.1314"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Naganawa S, Ito R, Kawamura M, Taoka T, Yoshida T, Sone M. The endolymph signal in non\u2013contrast enhanced 3D\u2013real IR image differs between the ears with and without significant endolymphatic hydrops. Magn Reson Med Sci 2025. [Epub ahead of print]","DOI":"10.2463\/mrms.mp.2024-0191"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Naganawa S, Yamazaki M, Kawai H, Bokura K, Sone M, Nakashima T. Imaging of M\u00e9ni\u00e8re\u2019s disease after intravenous administration of single-dose gadodiamide: Utility of subtraction images with different inversion time. Magn Reson Med Sci 2012; 11:213\u2013219.","DOI":"10.2463\/mrms.11.213"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Naganawa S, Yamazaki M, Kawai H, Bokura K, Sone M, Nakashima T. Imaging of M\u00e9ni\u00e8re\u2019s disease after intravenous administration of single-dose gadodiamide: Utility of multiplication of MR cisternography and HYDROPS image. Magn Reson Med Sci 2013; 12:63\u201368.","DOI":"10.2463\/mrms.2012-0027"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Naganawa S, Ohashi T, Kanou M, Kuno K, Sone M, Ikeda M. Volume quantification of endolymph after intravenous administration of a single dose of gadolinium contrast agent: Comparison of 18- versus 8-minute imaging protocols. Magn Reson Med Sci 2015; 14:257\u2013262.","DOI":"10.2463\/mrms.2014-0118"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Nakashima T, Naganawa S, Pyykk\u00f6 I, et al. Grading of endolymphatic hydrops using magnetic resonance imaging. Acta Otolaryngol 2009; 129(sup560):5\u20138.","DOI":"10.1080\/00016480902729827"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Naganawa S, Ito R, Nakamichi R, et al. Relationship between time-dependent signal changes in parasagittal perivenous cysts and leakage of gadolinium-based contrast agents into the subarachnoid space. Magn Reson Med Sci 2021; 20:378\u2013384.","DOI":"10.2463\/mrms.mp.2020-0138"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Naganawa S, Ito R, Kawamura M, Taoka T, Yoshida T, Sone M. Peripheral retinal leakage after intravenous administration of a gadolinium-based contrast agent: Age dependence, temporal and inferior predominance and potential implications for eye homeostasis. Magn Reson Med Sci 2023; 22:45\u201355.","DOI":"10.2463\/mrms.mp.2021-0100"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Naganawa S, Ito R, Kawamura M, Taoka T, Yoshida T, Sone M. Association between the putative meningeal lymphatics at the posterior wall of the sigmoid sinus and delayed contrast-agent elimination from the cerebrospinal fluid. Magn Reson Med Sci 2024; 23:80\u201391.","DOI":"10.2463\/mrms.mp.2022-0110"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Ohashi T, Naganawa S, Iwata S, Kuno K. Distribution of gadolinium-based contrast agent after leaking into the cerebrospinal fluid: Comparison between the cerebral cisterns and the lateral ventricles. Magn Reson Med Sci 2021; 20:175\u2013181.","DOI":"10.2463\/mrms.mp.2020-0016"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Naganawa S, Ito R, Kawamura M, Taoka T, Yoshida T, Sone M. Preliminary findings on non\u2013contrast enhanced positive endolymph images: Limited delineation of endolymphatic space. Magn Reson Med Sci 2025. [Epub ahead of print]","DOI":"10.2463\/mrms.bc.2025-0005"}],"container-title":["Magnetic Resonance in Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/mrms\/25\/1\/25_mp.2025-0068\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T03:57:42Z","timestamp":1769831862000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/mrms\/25\/1\/25_mp.2025-0068\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.2463\/mrms.mp.2025-0068","relation":{},"ISSN":["1347-3182","1880-2206"],"issn-type":[{"value":"1347-3182","type":"print"},{"value":"1880-2206","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"mp.2025-0068"}}