{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:54:06Z","timestamp":1787025246401,"version":"build-2736575974"},"reference-count":25,"publisher":"Japanese Society for Magnetic Resonance in Medicine","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MRMS","magn reson med sci"],"published-print":{"date-parts":[[2026]]},"DOI":"10.2463\/mrms.mp.2025-0211","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T22:08:33Z","timestamp":1773871713000},"page":"n\/a","source":"Crossref","is-referenced-by-count":1,"title":["Histopathological Basis of Peritumoral Enhancement in Muscle-invasive Bladder Cancer"],"prefix":"10.2463","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0855-0658","authenticated-orcid":false,"given":"Hiroyuki","family":"Watanabe","sequence":"first","affiliation":[{"name":"Department of Radiology, Kawasaki Medical School, Kurashiki, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3005-8487","authenticated-orcid":false,"given":"Mitsuru","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Radiology, Kawasaki Medical School, Kurashiki, Okayama, Japan"},{"name":"Department of Radiology, Radiolonet Tokai, Nagoya, Aichi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4857-4372","authenticated-orcid":false,"given":"Atsushi","family":"Higaki","sequence":"additional","affiliation":[{"name":"Department of Radiology, Kawasaki Medical School, Kurashiki, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4193-2427","authenticated-orcid":false,"given":"Yuichi","family":"Kojima","sequence":"additional","affiliation":[{"name":"Department of Radiology, Kawasaki Medical School, Kurashiki, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuma","family":"Maruhisa","sequence":"additional","affiliation":[{"name":"Department of Radiology, Kawasaki Medical School, Kurashiki, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7220-3446","authenticated-orcid":false,"given":"Akira","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Radiology, Kawasaki Medical School, Kurashiki, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Moriya","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kawasaki Medical School, Kurashiki, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2521-9570","authenticated-orcid":false,"given":"Tsutomu","family":"Tamada","sequence":"additional","affiliation":[{"name":"Department of Radiology, Kawasaki Medical School, Kurashiki, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1295","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2021; 71:209\u2013249.","DOI":"10.3322\/caac.21660"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Tran L, Xiao JF, Agarwal N, Duex JE, Theodorescu D. Advances in bladder cancer biology and therapy. Nat Rev Cancer 2021; 21:104\u2013121.","DOI":"10.1038\/s41568-020-00313-1"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Babjuk M, Burger M, Capoun O, et al. European Association of Urology guidelines on non-muscle-invasive bladder cancer (Ta, T1, and carcinoma in situ). Eur Urol 2022; 81:75\u201394.","DOI":"10.1016\/j.eururo.2021.08.010"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Holzbeierlein JM, Bixler BR, Buckley DI, et al. Diagnosis and treatment of non-muscle invasive bladder cancer: AUA\/SUO guideline: 2024 amendment. J Urol 2024; 211:533\u2013538.","DOI":"10.1097\/JU.0000000000003846"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Flaig TW, Spiess PE, Agarwal N, et al. Bladder Cancer, Version 3.2020, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw 2020; 18:329\u2013354.","DOI":"10.6004\/jnccn.2020.0011"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Powles T, Bellmunt J, Comperat E, et al. Bladder cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up. Ann Oncol 2022; 33:244\u2013258.","DOI":"10.1016\/j.annonc.2021.11.012"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Cumberbatch MGK, Foerster B, Catto JWF, et al. Repeat transurethral resection in non-muscle-invasive bladder cancer: A systematic review. Eur Urol 2018; 73:925\u2013933.","DOI":"10.1016\/j.eururo.2018.02.014"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Panebianco V, Narumi Y, Altun E, et al. Multiparametric magnetic resonance imaging for bladder cancer: Development of VI-RADS (Vesical Imaging-Reporting And Data System). Eur Urol 2018; 74:294\u2013306.","DOI":"10.1016\/j.eururo.2018.04.029"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Jazayeri SB, Dehghanbanadaki H, Hosseini M, et al. Diagnostic accuracy of vesical imaging-reporting and data system (VI-RADS) in suspected muscle invasive bladder cancer: A systematic review and diagnostic meta-analysis. Urol Oncol 2022; 40:45\u201355.","DOI":"10.1016\/j.urolonc.2021.11.008"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Wang H, Luo C, Zhang F, et al. Multiparametric MRI for bladder cancer: Validation of VI-RADS for the detection of detrusor muscle invasion. Radiology 2019; 291:668\u2013674.","DOI":"10.1148\/radiol.2019182506"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Ueno Y, Takeuchi M, Tamada T, et al. Diagnostic accuracy and interobserver agreement for the Vesical Imaging-Reporting and Data System for muscle-invasive bladder cancer: A multireader validation study. Eur Urol 2019; 76:54\u201356.","DOI":"10.1016\/j.eururo.2019.03.012"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Do\u011fan MB, G\u00fcnd\u00fcz N, Kazan H, \u00c7ak\u0131c\u0131 M, Y\u0131ld\u0131r\u0131m A, Erdem G. Contribution of lesion shape features to the VI-RADS for predicting muscle invasion in bladder tumors. Eur J Radiol 2025; 187:112104.","DOI":"10.1016\/j.ejrad.2025.112104"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Zhang X, Xu X, Wang Y, et al. Reduced field-of-view DWI based on deep learning reconstruction improving diagnostic accuracy of VI-RADS for evaluating muscle invasion. Insights Imaging 2024; 15:139.","DOI":"10.1186\/s13244-024-01686-9"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Bicchetti M, Simone G, Giannarini G, et al. A novel pathway to detect muscle-invasive bladder cancer based on integrated clinical features and VI-RADS score on MRI: Results of a prospective multicenter study. Radiol Med 2022; 127:881\u2013890.","DOI":"10.1007\/s11547-022-01513-5"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Takeuchi M, Higaki A, Kojima Y, et al. Diagnostic significance of peritumoral enhancement in distinguishing between muscle-invasive and non-muscle-invasive bladder cancer. Abdom Radiol (NY) 2025; 50:1679\u20131688.","DOI":"10.1007\/s00261-024-04658-1"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Fujii S, Kido A, Baba T, et al. Subendometrial enhancement and peritumoral enhancement for assessing endometrial cancer on dynamic contrast enhanced MR imaging. Eur J Radiol 2015; 84:581\u2013589.","DOI":"10.1016\/j.ejrad.2015.01.004"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Sharma P, Shen Y, Wen S, et al. CD8 tumor-infiltrating lymphocytes are predictive of survival in muscle-invasive urothelial carcinoma. Proc Natl Acad Sci USA 2007; 104:3967\u20133972.","DOI":"10.1073\/pnas.0611618104"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Patwardhan MV, Mahendran R. The bladder tumor microenvironment components that modulate the tumor and impact therapy. Int J Mol Sci 2023; 24:12311.","DOI":"10.3390\/ijms241512311"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Takeuchi M, Tamada T, Higaki A, Kojima Y, Ueno Y, Yamamoto A. Pictorial review of the diagnosis of muscle-invasive bladder cancer using vesical imaging-reporting and data system (VI-RADS). Abdom Radiol (NY) 2024; 49:4463\u20134480.","DOI":"10.1007\/s00261-024-04424-3"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Feng C, Wang Y, Song W, et al. Spatially-resolved analyses of muscle invasive bladder cancer microenvironment unveil a distinct fibroblast cluster associated with prognosis. Front Immunol 2024; 15:1522582.","DOI":"10.3389\/fimmu.2024.1522582"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Samaratunga H, Fairweather P, Purdie D. Significance of stromal reaction patterns in invasive urothelial carcinoma. Am J Clin Pathol 2005; 123:851\u2013857.","DOI":"10.1309\/EE8RTB6X1611G6TU"},{"key":"22","unstructured":"22. Shimasaki N, Kuroda N, Miyazaki E, et al. The distribution pattern of myofibroblasts in the stroma of human bladder carcinoma depends on their invasiveness. Histol Histopathol 2006; 21:349\u2013353."},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Adelmann TG, Ceau\u015fu AR, Gaje NP, Raica M. Endothelial cell proliferation and vascular patterns in urothelial carcinoma. Rom J Morphol Embryol 2024; 65:61\u201367.","DOI":"10.47162\/RJME.65.1.08"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Ma Y, Sun Y, Guo H, Yang R. Tumor-associated macrophages in bladder cancer: Roles and targeted therapeutic strategies. Front Immunol 2024; 15:1418131.","DOI":"10.3389\/fimmu.2024.1418131"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Capaldo CT, Nusrat A. Cytokine regulation of tight junctions. Biochim Biophys Acta Biomembr 2009; 1788:864\u2013871.","DOI":"10.1016\/j.bbamem.2008.08.027"}],"container-title":["Magnetic Resonance in Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/mrms\/25\/3\/25_mp.2025-0211\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T05:03:32Z","timestamp":1783141412000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/mrms\/25\/3\/25_mp.2025-0211\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.2463\/mrms.mp.2025-0211","relation":{},"ISSN":["1347-3182","1880-2206"],"issn-type":[{"value":"1347-3182","type":"print"},{"value":"1880-2206","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"mp.2025-0211"}}