{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T05:03:07Z","timestamp":1781326987440,"version":"3.54.1"},"reference-count":46,"publisher":"Japanese Society for Magnetic Resonance in Medicine","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MRMS","magn reson med sci"],"published-print":{"date-parts":[[2022]]},"DOI":"10.2463\/mrms.rev.2021-0156","type":"journal-article","created":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T22:07:43Z","timestamp":1645135663000},"page":"354-364","source":"Crossref","is-referenced-by-count":18,"title":["Clinical Application of 4D Flow MR Imaging for the Abdominal Aorta"],"prefix":"10.2463","volume":"21","author":[{"given":"Yasuo","family":"Takehara","sequence":"first","affiliation":[{"name":"Departments of Fundamental Development for Low Invasive Diagnostic Imaging and Radiology, Nagoya University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1295","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Ando J, Komatsuda T, Ishikawa C, Kamiya A. Fluid shear stress enhanced DNA synthesis in cultured endothelial cells during repair of mechanical denudation. Biorheology 1990; 27:675\u2013684.","DOI":"10.3233\/BIR-1990-27505"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Ando J, Yamamoto K. Hemodynamic forces, endothelial mechanotransduction, and vascular diseases. Magn Reson Med Sci 2022; 21:258\u2013266.","DOI":"10.2463\/mrms.rev.2021-0018"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Malek AM, Alper SL, Izumo S. Hemodynamic shear stress and its role in atherosclerosis. JAMA 1999; 282:2035\u20132042.","DOI":"10.1001\/jama.282.21.2035"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Malek AM, Izumo S. Control of endothelial cell gene expression by flow. J Biomech 1995; 28:1515\u20131528.","DOI":"10.1016\/0021-9290(95)00099-2"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Rogers WJ, Hu YL, Coast D, et al. Age-associated changes in regional aortic pulse wave velocity. J Am Coll Cardiol 2001; 38:1123\u20131129.","DOI":"10.1016\/S0735-1097(01)01504-2"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Dietenbeck T, Craiem D, Rosenbaum D, et al. 3D aortic morphology and stiffness in MRI using semi-automated cylindrical active surface provides optimized description of the vascular effects of aging and hypertension. Comput Biol Med 2018; 103:101\u2013108.","DOI":"10.1016\/j.compbiomed.2018.10.006"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Hwang J, Ing MH, Salazar A, et al. Pulsatile versus oscillatory shear stress regulates NADPH oxidase subunit expression: implication for native LDL oxidation. Circ Res 2003; 93:1225\u20131232.","DOI":"10.1161\/01.RES.0000104087.29395.66"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Tsuji T, Suzuki J, Shimamoto R, et al. Vector analysis of the wall shear rate at the human aortoiliac bifurcation using cine MR velocity mapping. AJR Am J Roentgenol 2002; 178:995\u2013999.","DOI":"10.2214\/ajr.178.4.1780995"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Wehrum T, Dragonu I, Strecker C, et al. Influence of pulse wave velocity on atherosclerosis and blood flow reversal in the aorta: A 4-dimensional flow magnetic resonance imaging study in acute stroke patients and matched controls. J Thorac Imaging 2022; 37:42\u201348.","DOI":"10.1097\/RTI.0000000000000580"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Winter P, Andelovic K, Kampf T, et al. Simultaneous measurements of 3D wall shear stress and pulse wave velocity in the murine aortic arch. J Cardiovasc Magn Reson 2021; 23:34.","DOI":"10.1186\/s12968-021-00725-4"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Hermann I, Shchetynska-Marinova T, Amendt K, et al. First experiences of local pulse wave velocity measurements in 4D-MRI in focally stented femoropopliteal arteries. Vasa 2021; 50:468\u2013474.","DOI":"10.1024\/0301-1526\/a000965"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Honda T, Itatani K, Takanashi M, et al. Quantitative evaluation of hemodynamics in the Fontan circulation: a cross-sectional study measuring energy loss in vivo. Pediatr Cardiol 2014; 35:361\u2013367.","DOI":"10.1007\/s00246-013-0783-4"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Itatani K, Okada T, Uejima T, et al. Intraventricular flow velocity vector visualization based on the continuity equation and measurements of vorticity and wall shear stress. Jpn J Appl Phys 2013; 52:07HF16.","DOI":"10.7567\/JJAP.52.07HF16"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Itatani K, Sekine T, Maeda Y, et al. Hemodynamic parameters for cardiovascular system in 4D flow MRI: Mathematical definition and clinical applications. Magn Reson Med Sci 2022; 21: 380\u2013399.","DOI":"10.2463\/mrms.rev.2021-0097"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Iwata K, Sekine T, Tanaka I, Ando T, Orita E. Turbulent kinetic energy is different from viscous energy loss. Radiographics 2020; 40:2142\u20132144.","DOI":"10.1148\/rg.2020200177"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Elbaz MSM, Scott MB, Barker AJ, et al. Four-dimensional virtual catheter: Noninvasive assessment of intra-aortic hemodynamics in bicuspid aortic valve disease. Radiology 2019; 293:541\u2013550.","DOI":"10.1148\/radiol.2019190411"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Oyama-Manabe N, Aikawa T, Tsuneta S, Manabe O. Clinical applications of 4D flow MR imaging in aortic valvular and congenital heart disease. Magn Reson Med Sci 2022; 21:319\u2013326.","DOI":"10.2463\/mrms.rev.2021-0030"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Ha H, Kim GB, Kweon J, et al. Turbulent kinetic energy measurement using phase contrast mri for estimating the post-stenotic pressure drop: In vitro validation and clinical application. PLoS One 2016; 11:e0151540.","DOI":"10.1371\/journal.pone.0151540"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Learoyd BM, Taylor MG. Alterations with age in the viscoelastic properties of human arterial walls. Circ Res 1966; 18:278\u2013292.","DOI":"10.1161\/01.RES.18.3.278"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Sehgel NL, Sun Z, Hong Z, et al. Augmented vascular smooth muscle cell stiffness and adhesion when hypertension is superimposed on aging. Hypertension 2015; 65:370\u2013377.","DOI":"10.1161\/HYPERTENSIONAHA.114.04456"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Sehgel NL, Vatner SF, Meininger GA. \u201cSmooth muscle cell stiffness syndrome\u201d-Revisiting the structural basis of arterial stiffness. Front Physiol 2015; 6:335.","DOI":"10.3389\/fphys.2015.00335"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Sugawara J, Hayashi K, Yokoi T, Tanaka H. Age-associated elongation of the ascending aorta in adults. JACC Cardiovasc Imaging 2008; 1:739\u2013748.","DOI":"10.1016\/j.jcmg.2008.06.010"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Brewster DC, Cronenwett JL, Hallett JW Jr., Johnston KW, Krupski WC, Matsumura JS. Guidelines for the treatment of abdominal aortic aneurysms. Report of a subcommittee of the Joint Council of the American Association for Vascular Surgery and Society for Vascular Surgery. J Vasc Surg 2003; 37:1106\u20131117.","DOI":"10.1067\/mva.2003.363"},{"key":"24","unstructured":"24. Prager M, Claeys L, Fugl A, et al. Abdominal aortic aneurysm: surgery, indications, technique, outcome. Acta Med Austriaca 1997; 24:10\u201314."},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Takehara Y, Isoda H, Takahashi M, et al. Abnormal flow dynamics result in low wall shear stress and high oscillatory shear index in abdominal aortic dilatation: Initial in vivo assessment with 4D-flow MRI. Magn Reson Med Sci 2020; 19:235\u2013246.","DOI":"10.2463\/mrms.mp.2019-0188"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Webb G. Magnetohydrodynamics and fluid dynamics: Action principles and conservation laws. Cham: Springer International Pulishing 2018.","DOI":"10.1007\/978-3-319-72511-6"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Anton R, Chen CY, Hung MY, Finol EA, Pekkan K. Experimental and computational investigation of the patient-specific abdominal aortic aneurysm pressure field. Comput Methods Biomech Biomed Engin 2015; 18:981\u2013992.","DOI":"10.1080\/10255842.2013.865024"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Katahashi K, Sano M, Takehara Y, Inuzuka K, Sugiyama M, Alley MT, et al. Flow dynamics of type II endoleaks can determine sac expansion after endovascular aneurysm repair using four-dimensional flow-sensitive magnetic resonance imaging analysis. J Vasc Surg 2019; 70:107\u2013116.e1.","DOI":"10.1016\/j.jvs.2018.09.048"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Fukuyama A, Isoda H, Morita K, et al. Influence of spatial resolution in three-dimensional cine phase contrast magnetic resonance imaging on the accuracy of hemodynamic analysis. Magn Reson Med Sci 2017; 16:311\u2013316.","DOI":"10.2463\/mrms.mp.2016-0060"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Amano Y, Sekine T, Suzuki Y, Tanaka K, Takagi R, Kumita S. Time-resolved three-dimensional magnetic resonance velocity mapping of chronic thoracic aortic dissection: a preliminary investigation. Magn Reson Med Sci 2011; 10:93\u201399.","DOI":"10.2463\/mrms.10.93"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Chen CW, Fang YF, Tseng YH, et al. Before and after endovascular aortic repair in the same patients with aortic dissection: A cohort study of four-dimensional phase-contrast magnetic resonance imaging. Diagnostics (Basel) 2021; 11:1912.","DOI":"10.3390\/diagnostics11101912"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Chen CW, Tseng YH, Lin CC, et al. Aortic dissection assessment by 4D phase-contrast MRI with hemodynamic parameters: the impact of stent type. Quant Imaging Med Surg 2021; 11:490\u2013501.","DOI":"10.21037\/qims-20-670"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Liu D, Fan Z, Li Y, et al. Quantitative study of abdominal blood flow patterns in patients with aortic dissection by 4-dimensional flow MRI. Sci Rep 2018; 8:9111.","DOI":"10.1038\/s41598-018-27249-9"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Saitta S, Guo B, Pirola S, et al. Qualitative and quantitative assessments of blood flow on tears in type B aortic dissection with different morphologies. Front Bioeng Biotechnol 2021; 9:742985.","DOI":"10.3389\/fbioe.2021.742985"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Allen BD, Aouad PJ, Burris NS, Rahsepar AA, Jarvis KB, Francois CJ, et al. Detection and hemodynamic evaluation of flap fenestrations in type B aortic dissection with 4D flow MRI: Comparison with conventional MRI and CTA. Radiol Cardiothorac Imaging. 2019; 1:e180009.","DOI":"10.1148\/ryct.2019180009"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Inoue T, Watanabe S, Sakurada H, et al. Evaluation of flow volume and flow patterns in the patent false lumen of chronic aortic dissections using velocity-encoded cine magnetic resonance imaging. Jpn Circ J 2000; 64:760\u2013764.","DOI":"10.1253\/jcj.64.760"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Francois CJ, Markl M, Schiebler ML, et al. Four-dimensional, flow-sensitive magnetic resonance imaging of blood flow patterns in thoracic aortic dissections. J Thorac Cardiovasc Surg 2013; 145:1359\u20131366.","DOI":"10.1016\/j.jtcvs.2012.07.019"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Clough RE, Waltham M, Giese D, Taylor PR, Schaeffter T. A new imaging method for assessment of aortic dissection using four-dimensional phase contrast magnetic resonance imaging. J Vasc Surg 2012; 55:914\u2013923.","DOI":"10.1016\/j.jvs.2011.11.005"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Takahashi K, Sekine T, Ando T, Ishii Y, Kumita S. Utility of 4D flow MRI in thoracic aortic diseases: A Literature Review of Clinical Applications and Current Evidence. Magn Reson Med Sci 2022; 21:327\u2013339.","DOI":"10.2463\/mrms.rev.2021-0046"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Takahashi K, Sekine T, Miyagi Y, et al. Four-dimensional flow analysis reveals mechanism and impact of turbulent flow in the dissected aorta. Eur J Cardiothorac Surg 2021; 60:1064\u20131072.","DOI":"10.1093\/ejcts\/ezab201"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Burris NS, Nordsletten DA, Sotelo JA, et al. False lumen ejection fraction predicts growth in type B aortic dissection: preliminary results. Eur J Cardiothorac Surg 2020; 57:896\u2013903.","DOI":"10.1093\/ejcts\/ezz343"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Zilber ZA, Boddu A, Malaisrie SC, et al. noninvasive morphologic and hemodynamic evaluation of type B aortic dissection: State of the art and future perspectives. Radiol Cardiothorac Imaging. 2021; 3:e200456.","DOI":"10.1148\/ryct.2021200456"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Rudenick PA, Segers P, Pineda V, et al. False lumen flow patterns and their relation with morphological and biomechanical characteristics of chronic aortic dissections. Computational model compared with magnetic resonance imaging measurements. PLoS One 2017; 12:e0170888.","DOI":"10.1371\/journal.pone.0170888"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44. Edwards DG, Schofield RS, Lennon SL, Pierce GL, Nichols WW, Braith RW. Effect of exercise training on endothelial function in men with coronary artery disease. Am J Cardiol 2004; 93:617\u2013620.","DOI":"10.1016\/j.amjcard.2003.11.032"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45. Edwards DG, Schofield RS, Magyari PM, Nichols WW, Braith RW. Effect of exercise training on central aortic pressure wave reflection in coronary artery disease. Am J Hypertens 2004; 17:540\u2013543.","DOI":"10.1016\/j.amjhyper.2003.12.001"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46. Takehara Y, Isoda H, Takahashi M, et al.  Abnormal flow dynamics result in low wall shear stress and high oscillatory shear index in abdominal aortic dilation: Initial in vivo assessment with 4D\u2013flow MRI. Magn Reson Med Sci 2020; 19:235\u2013246.","DOI":"10.2463\/mrms.mp.2019-0188"}],"container-title":["Magnetic Resonance in Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/mrms\/21\/2\/21_rev.2021-0156\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T04:38:49Z","timestamp":1646455129000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/mrms\/21\/2\/21_rev.2021-0156\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.2463\/mrms.rev.2021-0156","relation":{},"ISSN":["1347-3182","1880-2206"],"issn-type":[{"value":"1347-3182","type":"print"},{"value":"1880-2206","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]},"article-number":"rev.2021-0156"}}