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Of the 78, 24% or 19 reported increased tics upon exposure to heat. Compared to the remaining 59 subjects, there were no differences in sex distribution, current age, or overall course of illness. In the thermal challenge, there was general increase in tics that was correlated with sweat rate ( r = .55, p=.001). This effect was prominent in 5 of 10 subjects ( rs = .29 to .63). There were no mean differences in current age, age of onset, or current severity of symptoms between the five subjects of each group. Tic symptoms in a subgroup of patients with Tourette syndrome may be sensitive to heat. Abnormal heat regulation is not a likely explanation for the observed increase in tics. The increase may be due to normal heat-loss mechanisms through dopaminergic pathways.<\/jats:p>","DOI":"10.2466\/pms.2001.92.2.419","type":"journal-article","created":{"date-parts":[[2011,8,31]],"date-time":"2011-08-31T13:02:38Z","timestamp":1314795758000},"page":"419-432","source":"Crossref","is-referenced-by-count":28,"title":["Thermal Sensitivity in Tourette Syndrome: Preliminary Report"],"prefix":"10.1177","volume":"92","author":[{"given":"Lawrence","family":"Scahill","sequence":"first","affiliation":[{"name":"Child Study Center, Yale School of Nursing, Yale University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul J.","family":"Lombroso","sequence":"additional","affiliation":[{"name":"Child Study Center, Yale University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Mack","sequence":"additional","affiliation":[{"name":"John B. 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