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Laughter after viewing \u201cModern Times\u201d also decreased nerve growth factor levels without affecting neurotrophin-3 levels in tears of those patients, while viewing a weather information video did not. These results indicate that laughter decreased allergen-specific IgE and IgG4 production and increased allergen-specific IgA production with concomitant decrease in nerve growth factor. These results indicate that laughter may have some implications for study and treatment of allergic diseases.<\/jats:p>","DOI":"10.2466\/pms.98.3.901-908","type":"journal-article","created":{"date-parts":[[2005,12,22]],"date-time":"2005-12-22T16:15:51Z","timestamp":1135268151000},"page":"901-908","source":"Crossref","is-referenced-by-count":12,"title":["Differential Effects of Laughter on Allergen-Specific Immunoglobulin and Neurotrophin Levels in Tears"],"prefix":"10.1177","volume":"98","author":[{"given":"Hajime","family":"Kimata","sequence":"first","affiliation":[{"name":"Department of Allergy, Ujitakeda Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2004,6,1]]},"reference":[{"key":"bibr1-pms.98.3.901-908","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2000.104782"},{"key":"bibr2-pms.98.3.901-908","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.22.10440"},{"key":"bibr3-pms.98.3.901-908","first-page":"62","volume":"7","author":"Berk L. 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