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A double-blind crossover design was used, and responses were evaluated with the Brief Psychiatric Rating Scale by 2 blinded raters. This produced a significant antimanic effect: total rating scores declined with anion treatment. Presham and postsham total scores for these 5 were 31.3 and 31.6, respectively. Pretreatment and posttreatment total scores were 31.6 and 26.3, respectively. Previous research indicates a role for serotonin in producing this antimanic effect.\n                  <\/jats:p>","DOI":"10.2466\/pr0.100.1.157-163","type":"journal-article","created":{"date-parts":[[2008,2,14]],"date-time":"2008-02-14T20:19:33Z","timestamp":1203020373000},"page":"157-163","source":"Crossref","is-referenced-by-count":3,"title":["Treatment of Acute Mania with Ambient Air Anionization: Variants of Climactic Heat Stress and Serotonin Syndrome"],"prefix":"10.1177","volume":"100","author":[{"given":"A. 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