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Psychological state was evaluated at baseline, at Month 3, and Month 6 by a psychiatrist using a Turkish version of the Hamilton Depression Rating Scale. Only one patient's score increased to the clinical level of depression at Month 3 of treatment and declined to subclinical levels at Month 6. Although Hamilton scores increased at Month 3 over baseline scores, except for one patient, others' scores remained below the subclinical level for depression. At the end of Month 6, the mean score decreased below that at Month 3. These changes in means might be related to the onset of clinical effect of isotretinoin.<\/jats:p>","DOI":"10.2466\/pr0.99.3.897-906","type":"journal-article","created":{"date-parts":[[2010,12,27]],"date-time":"2010-12-27T12:17:01Z","timestamp":1293452221000},"page":"897-906","source":"Crossref","is-referenced-by-count":21,"title":["Incidence of Depression Related to Isotretinoin Treatment in 100 ACNE Vulgaris Patients"],"prefix":"10.1177","volume":"99","author":[{"given":"Ye\u015fim","family":"Kaymak","sequence":"first","affiliation":[{"name":"Health Center, University of Gazi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Kalay","sequence":"additional","affiliation":[{"name":"Health Center, University of Gazi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilsel","family":"\u0130lter","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Gazi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ender","family":"Taner","sequence":"additional","affiliation":[{"name":"Health Center, University of Gazi"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2006,12,1]]},"reference":[{"key":"bibr1-PR0.99.3.897-906","volume-title":"Diagnostic and statistical manual of mental disorders (DSM-III)","author":"American Psychiatric Association","year":"1980","edition":"3"},{"key":"bibr2-PR0.99.3.897-906","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.113713"},{"key":"bibr3-PR0.99.3.897-906","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(88)70078-X"},{"key":"bibr4-PR0.99.3.897-906","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.5.983"},{"key":"bibr5-PR0.99.3.897-906","first-page":"193","volume":"97","author":"Brocq L.","year":"1891","journal-title":"Annales de Dermatologie et de Syphiligraphie (Paris)"},{"key":"bibr6-PR0.99.3.897-906","doi-asserted-by":"publisher","DOI":"10.1177\/070674379504000915"},{"key":"bibr7-PR0.99.3.897-906","doi-asserted-by":"publisher","DOI":"10.3810\/pgm.1998.10.1768"},{"key":"bibr8-PR0.99.3.897-906","first-page":"7","volume":"2","author":"Cunliffe W. 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