{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T14:59:36Z","timestamp":1775228376465,"version":"3.50.1"},"reference-count":19,"publisher":"Index Copernicus","issue":"1","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Positron-electron annihilation in living organisms occurs in about 30% via the formation of a metastable ortho-positronium atom that annihilates into two 511 keV photons in tissues because of the pick-off and conversion processes. Positronium (Ps) annihilation lifetime and intensities can be used to determine the size and quantity of defects in a material\u2019s microstructure, such as voids or pores in the range of nanometers. This is particularly true for blood clots. Here we present pilot investigations of positronium properties in fibrin clots. The studies are complemented by the use of SEM Edax and micro-computed tomography (\u00b5CT) to evaluate the extracted thrombotic material\u2019s properties. \u00b5CT is a versatile characterization method offering in situ and in operando possibilities and is a qualitative diagnostic tool. With \u00b5CT the presence of pores, cracks, and structural errors can be verified, and hence the 3D inner structure of samples can be investigated.<\/jats:p>","DOI":"10.2478\/bioal-2022-0087","type":"journal-article","created":{"date-parts":[[2022,12,24]],"date-time":"2022-12-24T14:17:46Z","timestamp":1671891466000},"page":"163-167","source":"Crossref","is-referenced-by-count":13,"title":["Feasibility study of positronium application for blood clots structural characteristics"],"prefix":"10.5604","volume":"18","author":[{"given":"Simbarashe","family":"Moyo","sequence":"first","affiliation":[{"name":"Department of Medical Physics, M. Smoluchowski Institute of Physics; Faculty of Physics, Astronomy and Applied Computer Science , Jagiellonian University ul . \u0141ojasiewicza 11, 30-348 Krak\u00f3w , Poland"}]},{"given":"Pawe\u0142","family":"Moskal","sequence":"additional","affiliation":[{"name":"Center for Theranostics, Jagiellonian University ul . Kopernika 40, 31-034 Krak\u00f3w , Poland ; Total-Body Jagiellonian-PET Laboratory , Jagiellonian University , Krak\u00f3w , Poland ; Department of Experimental Particle Physics and Applications, M. Smoluchowski Institute of Physics, Faculty of Physics, Astronomy and Applied Computer Science , Jagiellonian University , \u0141ojasiewicza 11 St, 30-348 Krakow , Poland"}]},{"given":"Ewa \u0141.","family":"St\u0119pie\u0144","sequence":"additional","affiliation":[{"name":"Department of Medical Physics, M. Smoluchowski Institute of Physics, Faculty of Physics, Astronomy and Applied Computer Science , Jagiellonian University ul . \u0141ojasiewicza 11, 30-348 Krak\u00f3w , Poland ; Center for Theranostics, Jagiellonian University ul . Kopernika 40, 31-034 Krak\u00f3w , Poland ; Total-Body Jagiellonian-PET Laboratory , Jagiellonian University , Krak\u00f3w , Poland"}]}],"member":"3689","published-online":{"date-parts":[[2022,12,24]]},"reference":[{"key":"2023110211523531254_j_bioal-2022-0087_ref_001","doi-asserted-by":"crossref","unstructured":"[1] St\u0119pie\u0144 E, Miszalski-Jamka T, Kapusta P, Tylko G, Pasowicz M. Beneficial effect of cigarette smoking cessation on fibrin clot properties. J Thromb Thrombolysis. 2011;32(2):177\u201382.","DOI":"10.1007\/s11239-011-0593-6"},{"key":"2023110211523531254_j_bioal-2022-0087_ref_002","doi-asserted-by":"crossref","unstructured":"[2] St\u0229pie\u0144 E, Plicner D, Branicka A, Stankiewicz E, Pazdan A, \u015aniezek-Maciejewska M, et al. Factors influencing thrombin generation measured as thrombinantithrombin complexes levels and using calibrated automated thrombogram in patients with advanced coronary artery disease. Pol Arch Med Wewn. 2007;117(7):297\u2013305.","DOI":"10.20452\/pamw.162"},{"key":"2023110211523531254_j_bioal-2022-0087_ref_003","doi-asserted-by":"crossref","unstructured":"[3] Moskal P, Dulski K, Chug N, Curceanu C, Czerwi\u0144ski E, Dadgar M, et al. Positronium imaging with the novel multiphoton PET scanner. Sci Adv. 2021; 7:eabh4394.","DOI":"10.1126\/sciadv.abh4394"},{"key":"2023110211523531254_j_bioal-2022-0087_ref_004","doi-asserted-by":"crossref","unstructured":"[4] Moskal P, Jasi\u0144ska B, St\u0119pie\u0144 E, Bass SD. Positronium in medicine and biology. Nat Rev Phys. 2019;1(9):527\u20139.","DOI":"10.1038\/s42254-019-0078-7"},{"key":"2023110211523531254_j_bioal-2022-0087_ref_005","doi-asserted-by":"crossref","unstructured":"[5] E. St\u0119pie\u0144 E. Kubicz, G. Grudzie\u0144, K. Dulski, B. Leszczy\u0144ski, P. Moskal, Positronium life-time as a new approach for cardiac masses imaging. 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Perspectives on translation of positronium imaging into clinics. Front Phys. 2022; 10:969806.","DOI":"10.3389\/fphy.2022.969806"},{"key":"2023110211523531254_j_bioal-2022-0087_ref_009","doi-asserted-by":"crossref","unstructured":"[9] Stepanov PS, Selim FA, Stepanov S V., Bokov A V., Ilyukhina O V., Dupl\u00e2tre G, et al. Interaction of positronium with dissolved oxygen in liquids. Phys Chem Chem Phys. 2020;22(9):5123\u201331.","DOI":"10.1039\/C9CP06105C"},{"key":"2023110211523531254_j_bioal-2022-0087_ref_010","doi-asserted-by":"crossref","unstructured":"[10] Moskal P, St\u0229pie\u0144 E. Positronium as a biomarker of hypoxia. Bio-Algorithms and Med-Systems. 2021;17(4):311\u20139.","DOI":"10.1515\/bams-2021-0189"},{"key":"2023110211523531254_j_bioal-2022-0087_ref_011","doi-asserted-by":"crossref","unstructured":"[11] Shibuya K, Saito H, Nishikido F, Takahashi M, Yamaya T. Oxygen sensing ability of positronium atom for tumor hypoxia imaging. 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Biomolecules. 2021;11(10):1\u201320.","DOI":"10.3390\/biom11101536"}],"container-title":["Bio-Algorithms and Med-Systems"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.sciendo.com\/pdf\/10.2478\/bioal-2022-0087","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T10:07:30Z","timestamp":1719223650000},"score":1,"resource":{"primary":{"URL":"https:\/\/bamsjournal.com\/resources\/html\/article\/details?id=617721"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,1]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,12,24]]},"published-print":{"date-parts":[[2022,12,1]]}},"alternative-id":["10.2478\/bioal-2022-0087"],"URL":"https:\/\/doi.org\/10.2478\/bioal-2022-0087","relation":{},"ISSN":["1896-530X"],"issn-type":[{"value":"1896-530X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,1]]}}}