{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T15:46:51Z","timestamp":1783784811752,"version":"3.55.0"},"reference-count":29,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T00:00:00Z","timestamp":1611878400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The criterion standard gonadotropin-releasing hormone (GnRH) stimulation tests to diagnose central precocious puberty (CPP) are time-consuming, inconvenient, and expensive.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To determine predictive cut-off values codetermined by ultrasonographic parameters and basal gonadotropin levels in girls with premature sexual development and compare them results of criterion standard tests in a study of diagnostic accuracy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Retrospective review of hormonal investigations and ultrasonographic uterine and ovarian parameters in a consecutive sample of girls at a single center, tertiary care hospital in Bangkok, Thailand.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We separated data from 68 girls (age range 2\u201312 years) into 2 groups based on their response to a GnRH analogue agonist stimulation test. A \u201cprepubertal response\u201d group included girls with premature thelarche and thelarche variants (n = 18, 6.37 \u00b1 1.77 years) and a \u201cpubertal response\u201d group, including girls with CPP (n = 50, 8.46 \u00b1 1.46 years); excluding patients with pathological causes (n = 0). The basal level of luteinizing hormone (LH) had the largest area under receiver operating characteristic curves (AUC) of 0.84; 95% confidence interval [CI] 0.74\u20130.93) compared with basal levels of follicle stimulating hormone (AUC 0.77; 95% CI 0.64\u20130.90) or estradiol (0.70; 95% CI 0.56\u20130.85). An optimal cut-off of 0.25 IU\/L LH was related to a pubertal response to GnRH analogue agonist stimulation tests with 75.0% sensitivity, 88.9% specificity, 94.7% positive predictive value (PPV), and 57.1% negative predictive value. Uterine and ovarian cut-off volumes of 3.5 cm<jats:sup>3<\/jats:sup> and 1.5 cm<jats:sup>3<\/jats:sup> were related to a pubertal response with 88.6% and 76.2% PPV, respectively. A uterine width cut-off of 1.7 cm combined with a basal LH cut-off of 0.25 IU\/L increased specificity and PPV to 100%.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Combining uterine and ovarian ultrasonographic parameters with basal gonadotropin levels, especially uterine width and basal LH level, appears useful for diagnosis of CPP.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2478\/abm-2021-0004","type":"journal-article","created":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T09:21:25Z","timestamp":1615454485000},"page":"27-34","source":"Crossref","is-referenced-by-count":3,"title":["Sensitivity and specificity of using pelvic ultrasonographic parameters combined with basal gonadotropin levels to diagnose central precocious puberty in Thai girls"],"prefix":"10.1515","volume":"15","author":[{"given":"Hataichanok B.","family":"Kongmanas","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine , Chulalongkorn University , Bangkok , Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4612-831X","authenticated-orcid":false,"given":"Panruethai","family":"Trinavarat","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine , Chulalongkorn University , Bangkok , Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0877-6562","authenticated-orcid":false,"given":"Suttipong","family":"Wacharasindhu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine , Chulalongkorn University , Bangkok , Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2021,1,29]]},"reference":[{"key":"2021052710523366935_j_abm-2021-0004_ref_001_w2aab3b7c14b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Carel JC, L\u00e9ger J. Clinical practice. Precocious puberty. N Engl J Med. 2008 May 29; 358(22):2366\u201377.","DOI":"10.1056\/NEJMcp0800459"},{"key":"2021052710523366935_j_abm-2021-0004_ref_002_w2aab3b7c14b1b6b1ab2b2b2Aa","doi-asserted-by":"crossref","unstructured":"Kauli R, Galatzer A, Kornreich L, Lazar L, Pertzelan A, Laron Z. Final height of girls with central precocious puberty, untreated versus treated with cyproterone acetate or GnRH analogue. A comparative study with re-evaluation of predictions by the Bayley-Pinneau method. Horm Res. 1997; 47:54\u201361.","DOI":"10.1159\/000185432"},{"key":"2021052710523366935_j_abm-2021-0004_ref_003_w2aab3b7c14b1b6b1ab2b2b3Aa","doi-asserted-by":"crossref","unstructured":"Jaruratanasirikul S, Thaiwong M. Etiologies of precocious puberty: 15-year experience in a tertiary hospital in southern Thailand. 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