{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T09:09:29Z","timestamp":1777280969103,"version":"3.51.4"},"reference-count":20,"publisher":"Walter de Gruyter GmbH","issue":"2","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic pancreatitis is the most common etiology of pancreaticopleural fistula (PPF) in children, and underlying genetic variations are now widely known, accounting for most chronic pediatric pancreatitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case report<\/jats:title>\n                    <jats:p>\n                      We describe a case of previously undetected chronic pancreatitis and PPF with a\n                      <jats:italic>SPINK1<\/jats:italic>\n                      variation in a 10-year-old Thai boy who presented with massive left pleural effusion. Magnetic resonance cholangiopancreatography (MRCP) revealed disruption of the pancreatic duct, which was communicating with a large pancreatic pseudocyst with mediastinal extension. The patient subsequently underwent endoscopic intervention with improved clinical symptoms. We also reviewed the imaging findings of 12 other reported cases of pediatric PPF.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Massive pleural effusion due to PPF can be an atypical manifestation in children with chronic pancreatitis. MRCP is the preferable imaging study for PPF due to the production of highly detailed images of pancreatic duct disruptions and anatomy, and the imaging is helpful to guide for appropriate treatment. Tests for genetic variation are also recommended in a child with chronic pancreatitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2478\/abm-2022-0012","type":"journal-article","created":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T03:18:13Z","timestamp":1654139893000},"page":"99-107","source":"Crossref","is-referenced-by-count":1,"title":["Pancreaticopleural fistula in a Thai boy with\n                    <i>SPINK1<\/i>\n                    c.101A&gt;G substitution variant-related chronic pancreatitis: a case report and literature review"],"prefix":"10.2478","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8714-5525","authenticated-orcid":false,"given":"Chomanad","family":"Chittchang","sequence":"first","affiliation":[{"name":"Department of Radiology, Faculty of Medicine , Prince of Songkla University , Hat Yai , Songkhla , Thailand"},{"name":"Department of Radiology , Queen Sirikit National Institute of Child Health , Ratchathewee , Bangkok , Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3351-6252","authenticated-orcid":false,"given":"Nisa","family":"Netinatsunton","sequence":"additional","affiliation":[{"name":"Nanthana-Kriangkrai Chotiwattanaphan (NKC) Institute of Gastroenterology and Hepatology, Songklanagarind Hospital , Department of Internal Medicine , Prince of Songkla University , Hat Yai , Songkhla , Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7749-5908","authenticated-orcid":false,"given":"Supika","family":"Kritsaneepaiboon","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine , Prince of Songkla University , Hat Yai , Songkhla , Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2022,4,29]]},"reference":[{"key":"2026042708182197483_j_abm-2022-0012_ref_001","doi-asserted-by":"crossref","unstructured":"Yang J, Lu L, Jin H-B, Yang JF, Zhang X-F. Endoscopic management of pancreaticopleural fistula in a pediatric patient: a case report and literature review. Medicine (Baltimore). 2020; 99:e20657. doi: 10.1097\/MD.0000000000020657","DOI":"10.1097\/MD.0000000000020657"},{"key":"2026042708182197483_j_abm-2022-0012_ref_002","doi-asserted-by":"crossref","unstructured":"Zhang J-Y, Deng Z-H, Gong B. Pancreaticopleural fistula in children with chronic pancreatitis: a case report and literature review. BMC Pediatr. 2020; 20:274. doi: 10.1186\/s12887-020-02174-x","DOI":"10.1186\/s12887-020-02174-x"},{"key":"2026042708182197483_j_abm-2022-0012_ref_003","doi-asserted-by":"crossref","unstructured":"Liu M, Xia T, Zhang D, Hu L, Liao Z, Sun C, Li Z. Genetic background and clinical characters of pediatric chronic pancreatitis: data and implications from the East. 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