{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T09:09:11Z","timestamp":1777280951426,"version":"3.51.4"},"reference-count":20,"publisher":"Walter de Gruyter GmbH","issue":"3","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although thyroid radiology has been conducted in patients with sickle cell anemia (SCA), to our knowledge, there is no report of thyroid gland assessment using ultrasonographic shear wave elastography (US-SWE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine values for ultrasonographic US-SWE of the thyroid in patients with SCA and correlations between thyroid elasticity and biochemical variables used to evaluate thyroid function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective case\u2013control observational study of 36 patients with SCA and 33 healthy volunteer controls. US-SWE measurements of thyroid gland parenchyma and biochemical parameters of the participants were obtained and compared, and the diagnostic accuracy of elasticity was determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The thyroid volume was smaller in patients with SCA than that in controls (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.001). Compared with the controls, the patients with SCA had significantly lower serum levels of free triiodothyronine (fT3) (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.004) and thyroglobulin (Tg) (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.001) and significantly higher levels of thyroid-stimulating hormone (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.028). Thyroid stiffness was significantly higher in the left lobe (LL) of the patients with SCA than in the controls (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.003). In the patients with SCA, we found a significant correlation between right lobe (RL) and LL stiffness and serum levels of Tg (RL [\n                      <jats:italic>r<\/jats:italic>\n                      = \u22120.439] and LL [\n                      <jats:italic>r<\/jats:italic>\n                      = \u22120.484];\n                      <jats:italic>P<\/jats:italic>\n                      = 0.021) and fT3 (RL [\n                      <jats:italic>r<\/jats:italic>\n                      = \u22120.463] and LL [\n                      <jats:italic>r<\/jats:italic>\n                      = \u22120.386];\n                      <jats:italic>P<\/jats:italic>\n                      = 0.012). Receiver operating characteristic (ROC) curve analysis of thyroid elasticity that represented a diagnosis of SCA found a cutoff of &gt;7.31 kPa, a sensitivity of 52.0%, and a specificity of 72.0% for the RL (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.316, area under the curve [AUC] 0.570), and a cutoff of &gt;8.06 kPa, a sensitivity of 58.0%, and a specificity of 84.0% for the LL (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.011, AUC 0.680).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>US-SWE can be used to follow up thyroid changes in patients with SCA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2478\/abm-2022-0017","type":"journal-article","created":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T04:43:23Z","timestamp":1661834603000},"page":"137-143","source":"Crossref","is-referenced-by-count":1,"title":["Ultrasonographic shear wave elastography of the thyroid in patients with sickle cell anemia"],"prefix":"10.2478","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4913-4838","authenticated-orcid":false,"given":"Gulen","family":"Burakgazi","sequence":"first","affiliation":[{"name":"Department of Radiology, Faculty of Medicine , Mustafa Kemal University , Antakya , Hatay , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1616-6358","authenticated-orcid":false,"given":"Gul","family":"Ilhan","sequence":"additional","affiliation":[{"name":"Department of Hematology, Faculty of Medicine , Mustafa Kemal University , Antakya , Hatay , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7486-503X","authenticated-orcid":false,"given":"Oguzhan","family":"Ozcan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine , Mustafa Kemal University , Antakya , Hatay , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3550-1326","authenticated-orcid":false,"given":"Emre","family":"Dirican","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Faculty of Medicine , Mustafa Kemal University , Antakya , Hatay , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2022,6,30]]},"reference":[{"key":"2026042708182496996_j_abm-2022-0017_ref_001","doi-asserted-by":"crossref","unstructured":"Piel FB, Steinberg MH, Rees DC. 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