{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:24:16Z","timestamp":1789691056770,"version":"4.0.1"},"reference-count":32,"publisher":"Walter de Gruyter GmbH","issue":"3","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"publisher","award":["4010990"],"award-info":[{"award-number":["4010990"]}],"id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The antioxidant system in a preterm neonate is premature. The imbalance between the prooxidant and antioxidant systems can make these neonates prone to oxidative stress. Birth asphyxia is one of the factors that can disturb this balance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We studied the prooxidant\u2013antioxidant balance (PAB) in the diagnosis and developmental prognosis of preterm neonates with asphyxia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cohort study has been conducted between 2016 and 2022 with 2 years follow-up on 183 premature neonates admitted to Ghaem Hospital Mashhad, by using a convenience sampling method. The data-collection tool and the researcher-made checklist included the mothers' and the neonate's information, and the third segment included laboratory information. PAB was studied by using standard solutions and the Enzyme immunoassays (ELISA) method. After discharging the newborns from the hospital, they were under follow-up at 6 months, 12 months, 18 months, and 24 months, by using the Denver II test. PAB was compared among newborns with asphyxia, those without asphyxia, and also newborns with normal and abnormal outcomes in both groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean \u00b1 standard deviation of the PAB factor reported is as follows: in newborns without asphyxia (21.00 \u00b1 18.14 HK), those with asphyxia (31.00 \u00b1 45.42 HK), in newborns with asphyxia having abnormal outcomes (40.00 \u00b1 60.84 HK), and those having normal outcomes (21.00 \u00b1 18.67 HK) (\n                      <jats:italic>P<\/jats:italic>\n                      \u2264 0.05). PAB results &gt;25 HK have been used for the diagnosis of asphyxia prognosis in newborns, with 83.3% sensitivity and 81% specificity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The PAB index showed a significant increase after asphyxia. It can be used as a diagnostic marker for the prognosis of premature newborns with asphyxia. Thus, diagnosis and prognosis of asphyxia in premature newborns can be predicted by using the PAB index.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2478\/abm-2024-0017","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T04:37:33Z","timestamp":1724042253000},"page":"116-124","source":"Crossref","is-referenced-by-count":1,"title":["The prooxidant\u2013antioxidant balance in diagnosis and developmental prognosis of premature neonates with asphyxia"],"prefix":"10.2478","volume":"18","author":[{"given":"Maryam","family":"Zakerihamidi","sequence":"first","affiliation":[{"name":"Department of Midwifery, School of Medical Sciences, Tonekabon Branch , Islamic Azad University , Tonekabon , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boskabadi","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine , Mashhad University of Medical Sciences , Mashhad , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amirkhani","family":"Samin","sequence":"additional","affiliation":[{"name":"Department of Midwifery, School of Medical Sciences, Tonekabon Branch , Islamic Azad University , Tonekabon , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2024,6,28]]},"reference":[{"key":"2026042708223964413_j_abm-2024-0017_ref_001","doi-asserted-by":"crossref","unstructured":"Quinn J-A, Munoz FM, Gonik B, Frau L, Cutland C, Mallett-Moore T, et al. Preterm birth: case definition and guidelines for data collection, analysis, and presentation of immunisation safety data. Vaccine. 2016; 34:6047\u201356.","DOI":"10.1016\/j.vaccine.2016.03.045"},{"key":"2026042708223964413_j_abm-2024-0017_ref_002","unstructured":"Institute of Medicine (US) Committee on Understanding Premature Birth and Assuring Healthy Outcomes. Preterm Birth: Causes, Consequences, and Prevention. Behrman RE, Butler AS, editors. Washington (DC): National Academies Press (US); 2007. PMID: 20669423."},{"key":"2026042708223964413_j_abm-2024-0017_ref_003","doi-asserted-by":"crossref","unstructured":"Liu L, Oza S, Hogan D, Chu Y, Perin J, Zhu J, et al. Global, regional, and national causes of under-5 mortality in 2000\u201315: an updated systematic analysis with implications for the Sustainable Development Goals. 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