{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T15:47:48Z","timestamp":1789832868108,"version":"4.0.1"},"reference-count":19,"publisher":"Walter de Gruyter GmbH","issue":"6","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Thiosulfate concentration in blood is an important indicator for the diagnosis of hydrogen sulfide poisoning. It may also be detected at high levels in postmortem decomposition cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine the effect of postmortem decomposition on blood thiosulfate concentration and define precautions for diagnosing hydrogen sulfide poisoning based on thiosulfate concentration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 57 cadavers (37 males and 20 females) of non-hydrogen sulfide poisoning-related deaths that underwent forensic autopsy in our department between 2016 and 2019 were classified into the non-decomposed (19 cases), partially decomposed (19 cases), and severely decomposed (19 cases) groups based on forensic findings. Blood samples collected from each case were analyzed for thiosulfate concentration using liquid chromatography\u2013tandem mass spectrometry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean concentration of thiosulfate detected in the blood was 70.9 (10.5\u2013266.6) \u03bcmol\/L in the severely decomposed group, 16.3 (0.1\u201352.7) \u03bcmol\/L in the partially decomposed group, and 1.1 (0.1\u20133.6) \u03bcmol\/L in the non-decomposed group. There was a statistically significant difference between each of the 3 groups (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Previous studies have reported a blood thiosulfate concentration of &gt;14 \u03bcmol\/L in hydrogen sulfide poisoning cases and &lt;4 \u03bcmol\/L in normal cases. Thus, thiosulfate concentration is believed to have a significant impact on the diagnosis of hydrogen sulfide poisoning. This study revealed that postmortem decomposition produced thiosulfate in the blood, and the concentration of thiosulfate was often as high as that observed in cases of hydrogen sulfide poisoning-related death. In addition to cases of advanced decomposition, an increase in thiosulfate concentration was also observed in cases of partial decomposition. Therefore, when measuring thiosulfate concentration as an indicator of hydrogen sulfide poisoning, it is necessary to carefully consider the influence of decomposition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2478\/abm-2024-0035","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T03:37:03Z","timestamp":1734406623000},"page":"281-286","source":"Crossref","is-referenced-by-count":3,"title":["Influence of blood thiosulfate produced by postmortem changes for the diagnosis of hydrogen sulfide poisoning in forensic autopsy"],"prefix":"10.2478","volume":"18","author":[{"given":"Masaaki","family":"Suzuka","sequence":"first","affiliation":[{"name":"Department of Radiology, Graduate School of Dental Medicine , Hokkaido University , Hokkaido , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeki","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine, Graduate School of Medicine , Hokkaido University , Hokkaido , Japan"},{"name":"Center for Cause of Death Investigation, Graduate School of Medicine , Hokkaido University , Hokkaido , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Center for Cause of Death Investigation, Graduate School of Medicine , Hokkaido University , Hokkaido , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Murakami","sequence":"additional","affiliation":[{"name":"Center for Medical Education and International Relations, Faculty of Medicine , Hokkaido University , Hokkaido , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine, Graduate School of Medicine , Hokkaido University , Hokkaido , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kotaro","family":"Matoba","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine, Graduate School of Medicine , Hokkaido University , Hokkaido , Japan"},{"name":"Center for Cause of Death Investigation, Graduate School of Medicine , Hokkaido University , Hokkaido , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2024,12,16]]},"reference":[{"key":"2026042708232240405_j_abm-2024-0035_ref_001","doi-asserted-by":"crossref","unstructured":"Kage S, Nagata T, Kudo K. 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