{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T16:42:21Z","timestamp":1786293741202,"version":"build-2736575974"},"reference-count":23,"publisher":"Walter de Gruyter GmbH","issue":"2","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>High mortality and poor prognosis are seen in gastric adenocarcinomas (GAs). Therefore, investigation of the factors related to GA prognosis is important.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the association between clinicopathological parameters and DNA mismatch repair (MMR) proteins as well as Epstein\u2013Barr virus (EBV) in GAs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Expression of MMR proteins and EBV positivity of 77 patients diagnosed with GA were evaluated using immunohistochemistry. Survival data of the patients were also considered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Significant correlations were found between EBV positivity and gender, perineural invasion (PNI), and histological type. PNI was less common in EBV-positive patients, and EBV positivity was highly correlated with lymphoid stromal adenocarcinoma. Tumor budding was significantly correlated with histological type and grade, lymphovascular invasion (LVI), PNI, lymph node metastasis, and post-diagnosis survival time. Moreover, tumor\u2013stroma ratio was correlated with tumor stage. Additionally, tumor location, histological grade, tumor budding, PNI, and pathological stage were associated with survival. Also, EBV positivity was significantly associated with histological type, PNI, tumor location, and gender. However, MMR and EBV positivity were not significantly correlated to tumor microenvironment and prognosis. It was noteworthy that the mortality rate was much higher in patients with PNI compared with those without PNI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings support that the tumor microenvironment is significantly associated with GA prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2478\/abm-2025-0011","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T08:21:09Z","timestamp":1750839669000},"page":"86-93","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of clinicopathological parameters with the presence of Epstein\u2013Barr virus and the absence of DNA mismatch repair proteins in gastric adenocarcinomas"],"prefix":"10.2478","volume":"19","author":[{"given":"\u00d6zge","family":"Eyeo\u011flu","sequence":"first","affiliation":[{"name":"Department of Clinical Pathology, Gaziantep City Hospital , Gaziantep , Turkey"},{"name":"Department of Clinical Pathology, Bilkent City Hospital , Ankara , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serra","family":"Kaya\u00e7etin","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Bilkent City Hospital , Ankara , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,4,30]]},"reference":[{"key":"2026080916120170711_j_abm-2025-0011_ref_001","doi-asserted-by":"crossref","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021; 71:209\u201349.","DOI":"10.3322\/caac.21660"},{"key":"2026080916120170711_j_abm-2025-0011_ref_002","doi-asserted-by":"crossref","unstructured":"Ilic M, Ilic I. Epidemiology of stomach cancer. World J Gastroenterol. 2022; 28:1187\u2013203.","DOI":"10.3748\/wjg.v28.i12.1187"},{"key":"2026080916120170711_j_abm-2025-0011_ref_003","doi-asserted-by":"crossref","unstructured":"Rawla P, Barsouk A. Epidemiology of gastric cancer: global trends, risk factors and prevention. Prz Gastroenterol. 2019; 14:26\u201338.","DOI":"10.5114\/pg.2018.80001"},{"key":"2026080916120170711_j_abm-2025-0011_ref_004","doi-asserted-by":"crossref","unstructured":"Guggenheim DE, Shah MA. Gastric cancer epidemiology and risk factors. 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