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The gut microbiota plays a vital role in regulating androgen production and metabolism, and can cross the blood\u2013testis barrier to influence spermatogenesis. This review highlights the significance of the gut\u2013testis axis in male reproductive and sexual health, based on extensive studies exploring how gut microbes impact testicular function. Gaining this understanding deepens our knowledge of the gut\u2013testis axis and its role in male reproductive health.<\/jats:p>","DOI":"10.2478\/abm-2026-0017","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:00:14Z","timestamp":1785852014000},"page":"149-154","source":"Crossref","is-referenced-by-count":1,"title":["Gut\u2013testis axis: how microbiota influence male reproductive health"],"prefix":"10.2478","volume":"20","author":[{"given":"Ruiyang","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine , The Second Clinical Medical College of Anhui Medical University , Hefei , Anhui , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxing","family":"Wu","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College of Anhui University of Chinese Medicine , Hefei , Anhui , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nianben","family":"Chen","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College of Anhui University of Chinese Medicine , Hefei , Anhui , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Urology, Chuzhou Integrated Hospital of Chinese and Western Medicine , Affiliated to Anhui University of Traditional Chinese Medicine , Chuzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinglin","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Urology, Chuzhou Integrated Hospital of Chinese and Western Medicine , Affiliated to Anhui University of Traditional Chinese Medicine , Chuzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"2026080416001536647_j_abm-2026-0017_ref_001","unstructured":"Zreloff ZJ, Lange D, Vernon SD, Carlin MR, Cano RJ. 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