{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T09:10:23Z","timestamp":1778490623198,"version":"3.51.4"},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"4","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The objective of the study was to enhance the solubility of carvedilol phosphate and to formulate it into non-effervescent floating tablets using swellable polymers. Solid dispersions (SD) of carvedilol were prepared with hydrophilic carriers such as polyvinylpyrrolidone and poloxamer to enhance solubility. Non-effervescent floating tablets were prepared with a combination of optimized solid dispersions and release retarding polymers\/swellable polymers such as xanthan gum and polyethylene oxide. Tablets were evaluated for physicochemical properties such as hardness, thickness and buoyancy. SD prepared with the drug to poloxamer ratio of 1:4 by melt granulation showed a higher dissolution rate than all other dispersions. Formulations containing 40 mg of polyethylene oxide (C-P40) and 50 mg xanthan gum (C-X50) were found to be best, with the drug retardation up to 12 hours. Optimized formulations were characterized using FTIR and DSC and no drug and excipient interactions were detected.<\/jats:p>","DOI":"10.2478\/acph-2014-0038","type":"journal-article","created":{"date-parts":[[2014,12,22]],"date-time":"2014-12-22T12:33:31Z","timestamp":1419251611000},"page":"485-494","source":"Crossref","is-referenced-by-count":10,"title":["Preparation and in vitro characterization of non-effervescent floating drug delivery system of poorly soluble drug, carvedilol phosphate"],"prefix":"10.2478","volume":"64","author":[{"given":"Venkata","family":"Srikanth Meka","sequence":"first","affiliation":[{"name":"School of Pharmacy, International Medical University, Bukit Jalil, 57000 Kuala Lumpur, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanitha A\/P Hong","family":"Wee Liang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, International Medical University, Bukit Jalil, 57000 Kuala Lumpur, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Senthil Rajan","family":"Dharmalingham","sequence":"additional","affiliation":[{"name":"School of Pharmacy, International Medical University, Bukit Jalil, 57000 Kuala Lumpur, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravi","family":"Sheshala","sequence":"additional","affiliation":[{"name":"School of Pharmacy, International Medical University, Bukit Jalil, 57000 Kuala Lumpur, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adinarayana","family":"Gorajana","sequence":"additional","affiliation":[{"name":"School of Pharmacy, International Medical University, Bukit Jalil, 57000 Kuala Lumpur, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2014,12,20]]},"container-title":["Acta Pharmaceutica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/content.sciendo.com\/view\/journals\/acph\/64\/4\/article-p485.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/reference-global.com\/pdf\/10.2478\/acph-2014-0038","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T08:38:46Z","timestamp":1778488726000},"score":1,"resource":{"primary":{"URL":"https:\/\/reference-global.com\/article\/10.2478\/acph-2014-0038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,1]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2014,12,20]]},"published-print":{"date-parts":[[2014,12,1]]}},"alternative-id":["10.2478\/acph-2014-0038"],"URL":"https:\/\/doi.org\/10.2478\/acph-2014-0038","relation":{},"ISSN":["1846-9558"],"issn-type":[{"value":"1846-9558","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,1]]}}}