{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T07:02:59Z","timestamp":1779865379627,"version":"3.53.1"},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"4","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This paper describes the seasonal phytochemical variation and the antimicrobial potential of V. zizanioides roots collected in Brazil. Considering the high levels of chemical constituents and their biological activity in dichloromethane fraction, the plants were grown in different seasons and the respective dichloromethane fractions were analyzed by gas chromatography-mass spectrometry. The antimicrobial activity was evaluated against several pathogenic microorganisms by determining the minimum inhibitory concentration (MIC) using the agar dilution method. Yields of dichloromethane fractions from plants collected in the autumn and spring occurred in a higher proportion than in other seasons. Khusimol (2) was isolated by column chromatography and identified by NMR and CG-MS, along with other sesquiterpenes, including \u03b2-vetivenene (1), vetiselinenol (3), isovalencenol (4), vetivenic acid (5), \u03b1-vetivone (6) and \u03b2-vetivone (7). Some extracts showed promising antimicrobial effects, with MICs ranging from 31.25 to 500 \u03bcg mL-1. Kushimol was slightly active against the tested microorganisms.<\/jats:p>","DOI":"10.2478\/acph-2014-0040","type":"journal-article","created":{"date-parts":[[2014,12,22]],"date-time":"2014-12-22T12:33:31Z","timestamp":1419251611000},"page":"495-501","source":"Crossref","is-referenced-by-count":14,"title":["Seasonal phytochemical study and antimicrobial potential of Vetiveria zizanioides roots"],"prefix":"10.2478","volume":"64","author":[{"given":"Delair Silveira","family":"Dos Santos","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas e N\u00facleo de Investiga\u00e7\u00f5es Qu\u00edmico-Farmac\u00eauticas (NIQFAR)-Universidade do Vale do Itaja\u00ed, 88302-202, Itaja\u00ed, SC, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00falia Vieira","family":"Oberger","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas e N\u00facleo de Investiga\u00e7\u00f5es Qu\u00edmico-Farmac\u00eauticas (NIQFAR)-Universidade do Vale do Itaja\u00ed, 88302-202, Itaja\u00ed, SC, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rivaldo","family":"Niero","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas e N\u00facleo de Investiga\u00e7\u00f5es Qu\u00edmico-Farmac\u00eauticas (NIQFAR)-Universidade do Vale do Itaja\u00ed, 88302-202, Itaja\u00ed, SC, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodoro","family":"Wagner","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas e N\u00facleo de Investiga\u00e7\u00f5es Qu\u00edmico-Farmac\u00eauticas (NIQFAR)-Universidade do Vale do Itaja\u00ed, 88302-202, Itaja\u00ed, SC, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Delle Monache","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas e N\u00facleo de Investiga\u00e7\u00f5es Qu\u00edmico-Farmac\u00eauticas (NIQFAR)-Universidade do Vale do Itaja\u00ed, 88302-202, Itaja\u00ed, SC, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre Bella","family":"Cruz","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas e N\u00facleo de Investiga\u00e7\u00f5es Qu\u00edmico-Farmac\u00eauticas (NIQFAR)-Universidade do Vale do Itaja\u00ed, 88302-202, Itaja\u00ed, SC, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhelmy","family":"Martin-Quintal","sequence":"additional","affiliation":[{"name":"Universidad Aut\u00f3noma de Yucat\u00e1n (UADY) Calle 41 No 421 x 26 y 28 Col. Industrial, C.P. 97150, M\u00e9rida Yucat\u00e1n, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valdir","family":"Cechinel Filho","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas e N\u00facleo de Investiga\u00e7\u00f5es Qu\u00edmico-Farmac\u00eauticas (NIQFAR)-Universidade do Vale do Itaja\u00ed, 88302-202, Itaja\u00ed, SC, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2014,12,20]]},"container-title":["Acta Pharmaceutica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/content.sciendo.com\/view\/journals\/acph\/64\/4\/article-p495.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/reference-global.com\/pdf\/10.2478\/acph-2014-0040","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T06:12:12Z","timestamp":1779862332000},"score":1,"resource":{"primary":{"URL":"https:\/\/reference-global.com\/article\/10.2478\/acph-2014-0040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,1]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2014,12,20]]},"published-print":{"date-parts":[[2014,12,1]]}},"alternative-id":["10.2478\/acph-2014-0040"],"URL":"https:\/\/doi.org\/10.2478\/acph-2014-0040","relation":{},"ISSN":["1846-9558"],"issn-type":[{"value":"1846-9558","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,1]]}}}