{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T22:39:55Z","timestamp":1787783995828,"version":"build-2784847793"},"reference-count":13,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2018,12,7]],"date-time":"2018-12-07T00:00:00Z","timestamp":1544140800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The present study is designed to find out if sesquiterpenes, \u03b1-humulene (HUM), valencene (VAL), \u03b2-caryphyllene-oxide (CAO) and\n                    <jats:italic>trans<\/jats:italic>\n                    -nerolidol (NER), are able to improve the antiproliferative effect of classical cytostatic drugs, 5-fluorouracil (FU) and oxaliplatin (1,2-diaminocyclohexaneoxalato-platinum, OxPt), in colon cancer cell lines Caco-2 and SW-620. In addition, the possible mechanisms of sesquiterpene action are studied. The results show significant ability of HUM and especially of CAO to enhance the anti-proliferative effects of FU and OxPt in cancer cell lines Caco-2 and SW-620. On the other hand, VAL and NER are ineffective. The action of CAO could be partly based on its ability to disrupt the mitochondrial membrane potential and to activate initiator caspases, but other mechanisms are probably also involved. Based on these results, CAO seems to have the potential for combination therapy of colon cancers and deserves further study.\n                  <\/jats:p>","DOI":"10.2478\/acph-2019-0003","type":"journal-article","created":{"date-parts":[[2018,12,9]],"date-time":"2018-12-09T04:31:22Z","timestamp":1544329882000},"page":"121-128","source":"Crossref","is-referenced-by-count":46,"title":["Sesquiterpenes \u03b1-humulene and \u03b2-caryophyllene oxide enhance the efficacy of 5-fluorouracil and oxaliplatin in colon cancer cells"],"prefix":"10.2478","volume":"69","author":[{"given":"Martin","family":"Ambro\u017e","sequence":"first","affiliation":[{"name":"Department of Biochemical Sciences Charles University in Prague Faculty of Pharmacy , Heyrovsk\u00e9ho 1203, Hradec Kr\u00e1lov\u00e9 , CZ-500 05 Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark\u00e9ta","family":"\u0160matov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Biochemical Sciences Charles University in Prague Faculty of Pharmacy , Heyrovsk\u00e9ho 1203, Hradec Kr\u00e1lov\u00e9 , CZ-500 05 Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"\u0160adibolov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Biochemical Sciences Charles University in Prague Faculty of Pharmacy , Heyrovsk\u00e9ho 1203, Hradec Kr\u00e1lov\u00e9 , CZ-500 05 Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Posp\u00ed\u0161ilov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Biochemical Sciences Charles University in Prague Faculty of Pharmacy , Heyrovsk\u00e9ho 1203, Hradec Kr\u00e1lov\u00e9 , CZ-500 05 Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavl\u00edna","family":"Hadravsk\u00e1","sequence":"additional","affiliation":[{"name":"Department of Biochemical Sciences Charles University in Prague Faculty of Pharmacy , Heyrovsk\u00e9ho 1203, Hradec Kr\u00e1lov\u00e9 , CZ-500 05 Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Ka\u0161parov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Biochemical Sciences Charles University in Prague Faculty of Pharmacy , Heyrovsk\u00e9ho 1203, Hradec Kr\u00e1lov\u00e9 , CZ-500 05 Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika Hanu\u0161ov\u00e1","family":"Skarkov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Medical Biology and Genetics , Charles University in Prague Faculty of Medicine in Hradec Kr\u00e1lov\u00e9 \u0160imkova 870, Hradec Kr\u00e1lov\u00e9 CZ-500 38 , Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u011bra","family":"Kr\u00e1lov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Medical Biology and Genetics , Charles University in Prague Faculty of Medicine in Hradec Kr\u00e1lov\u00e9 \u0160imkova 870, Hradec Kr\u00e1lov\u00e9 CZ-500 38 , Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenka","family":"Sk\u00e1lov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Biochemical Sciences Charles University in Prague Faculty of Pharmacy , Heyrovsk\u00e9ho 1203, Hradec Kr\u00e1lov\u00e9 , CZ-500 05 Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2018,12,7]]},"reference":[{"key":"2026051108203290476_j_acph-2019-0003_ref_001_w2aab2b8b2b1b7b1ab1ab1Aa","doi-asserted-by":"crossref","unstructured":"1. 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