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This article reviews various transdermal patches available in the market, types, structural components, polymer role, and the required assessment tools. Although transdermal patches have medical applications for smoking cessation, pain relief, osteoporosis, contraception, motion sickness, angina pectoris, and cardiac disorders, advances in formulation development are ongoing to make transdermal patches capable of delivering more challenging drugs. Transdermal patches can be tailored and developed according to the physicochemical properties of active and inactive components, and applicability for long-term use. Therefore, a number of chemical approaches and physical techniques for transdermal patch development are under investigation.<\/jats:p>","DOI":"10.2478\/acph-2019-0016","type":"journal-article","created":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T13:30:46Z","timestamp":1554125446000},"page":"197-215","source":"Crossref","is-referenced-by-count":164,"title":["Transdermal patches: Design and current approaches to painless drug delivery"],"prefix":"10.2478","volume":"69","author":[{"given":"Othman A.","family":"Al Hanbali","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy , The University of Sydney , Sydney NSW 2006, Australia"},{"name":"Dana Pharmaceuticals Factory , Zawata Road, Nablus-West Bank, Palestinian Authority"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haji Muhammad Shoaib","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Pharmacy and Alternative Medicine The Islamia University of Bahawalpur Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Sarfraz","sequence":"additional","affiliation":[{"name":"College of Pharmacy , Al Ain University of Science and Technology , Al Ain PO Box 64141 , Al Ain, Abu Dhabi, UAE"},{"name":"Faculty of Pharmacy and Pharmaceutical Sciences , University of Alberta Edmonton , AB T6G 2E1 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mosab","family":"Arafat","sequence":"additional","affiliation":[{"name":"College of Pharmacy , Al Ain University of Science and Technology , Al Ain PO Box 64141 , Al Ain, Abu Dhabi, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shakeel","family":"Ijaz","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Pharmacy and Alternative Medicine The Islamia University of Bahawalpur Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul","family":"Hameed","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Pharmacy and Alternative Medicine The Islamia University of Bahawalpur Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2019,3,28]]},"reference":[{"key":"2026053000405370239_j_acph-2019-0016_ref_001_w2aab3b7c11b1b6b1ab1ab1Aa","unstructured":"1. 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