{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:31:35Z","timestamp":1791498695226,"version":"4.3.4"},"reference-count":29,"publisher":"Walter de Gruyter GmbH","issue":"4","license":[{"start":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T00:00:00Z","timestamp":1571616000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Treatment of skin conditions with medicinal plants has been an ongoing human activity lasting over thousands of years. The use of specific plant species developed regionally, based on local flora. Commonly used medicinal plants for dermatological complaints are:\n                    <jats:italic>Phlebodium aureum<\/jats:italic>\n                    (L.) J. Sm.,\n                    <jats:italic>Ginkgo biloba<\/jats:italic>\n                    L.,\n                    <jats:italic>Rosmarinus officinalis<\/jats:italic>\n                    L.,\n                    <jats:italic>Panax ginseng<\/jats:italic>\n                    C.A.Mey.,\n                    <jats:italic>Allium cepa<\/jats:italic>\n                    L.,\n                    <jats:italic>Aloe vera<\/jats:italic>\n                    (L.) Burm.f.,\n                    <jats:italic>Capsicum annuum<\/jats:italic>\n                    L.,\n                    <jats:italic>Berbe ris aquifolium<\/jats:italic>\n                    Pursh,\n                    <jats:italic>Camellia sinensis<\/jats:italic>\n                    (L.) Kuntze, and\n                    <jats:italic>Podophyllum peltatum<\/jats:italic>\n                    L.\n                  <\/jats:p>\n                  <jats:p>The demand for complementary therapeutics is an emerging trend due to the awareness of potential side effects that synthetic drugs might cause. More scientific evidence and better documentation are needed before advising dermatologic patients on herbal medicinal treatment. Standardised extracts and formulations with proven clinical efficacy should be developed for this cause. Here provided review entails the use of herbal medicinal products in the treatment of frequent chronic skin diseases, such as vitiligo, alopecia, psoriasis and genital warts.<\/jats:p>","DOI":"10.2478\/acph-2019-0045","type":"journal-article","created":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T05:03:17Z","timestamp":1571720597000},"page":"525-531","source":"Crossref","is-referenced-by-count":25,"title":["Application of medicinal plants in several dermatovenerological entities"],"prefix":"10.2478","volume":"69","author":[{"given":"\u017deljan","family":"Male\u0161","sequence":"first","affiliation":[{"name":"University of Zagreb , Faculty of Pharmacy and Biochemistry Department of Pharmaceutical Botany 10000 Zagreb , Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela Ledi\u0107","family":"Drvar","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology , University Hospital Centre Zagreb , School of Medicine University of Zagreb , 10000 Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Duka","sequence":"additional","affiliation":[{"name":"University of Zagreb , Faculty of Pharmacy and Biochemistry Department of Pharmaceutical Botany 10000 Zagreb , Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"\u017du\u017eul","sequence":"additional","affiliation":[{"name":"Private Dermatology and Venereology Clinic \u201cDr. Nada Videni\u0107\u201d 47000 Karlovac , Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2019,10,21]]},"reference":[{"key":"2026051108212250796_j_acph-2019-0045_ref_001_w2aab2b8c13b1b7b1ab1ab1Aa","doi-asserted-by":"crossref","unstructured":"1. B. E. Cohen, N. Elbuluk, E. W. Mu and S. J. Orlow, Alternative Systemic Treatments for Vitiligo: A Review, Am. J. Clin. Dermatol.16 (2015) 463\u2013474; https:\/\/doi.org\/10.1007\/s40257-015-0153-510.1007\/s40257-015-0153-526329814","DOI":"10.1007\/s40257-015-0153-5"},{"key":"2026051108212250796_j_acph-2019-0045_ref_002_w2aab2b8c13b1b7b1ab1ab2Aa","doi-asserted-by":"crossref","unstructured":"2. F. Garcia, J. P. Pivel, A. Guerrero, A. Brieva, M. P. Martinez-Alcazar, M. Caamano-Somoza and S. Gonzalez, Phenolic components and antioxidant activity of Fernblock, an aqueous extract of the aerial parts of the fern Polypodium leucotomos, Methods Find Exp. Clin. Pharmacol.28 (2006) 157\u2013160; https:\/\/doi.org\/10.1358\/mf.2006.28.3.98522710.1358\/mf.2006.28.3.98522716810341","DOI":"10.1358\/mf.2006.28.3.985227"},{"key":"2026051108212250796_j_acph-2019-0045_ref_003_w2aab2b8c13b1b7b1ab1ab3Aa","doi-asserted-by":"crossref","unstructured":"3. S. M. A. Middelkamp-Hup, J. D. Bos, F. Rius-Diaz, S. Gonzalez and W. Westerhof, Treatment of vitiligo vulgaris with narrow-band UVB and oral Polypodium leucotomos extract: a randomized double-blind placebo-controlled study, J. Eur. Acad. Dermatol. Venereol. 21 (2007) 942\u2013950; https:\/\/doi.org\/10.1111\/j.1468-3083.2006.02132.x10.1111\/j.1468-3083.2006.02132.x17659004","DOI":"10.1111\/j.1468-3083.2006.02132.x"},{"key":"2026051108212250796_j_acph-2019-0045_ref_004_w2aab2b8c13b1b7b1ab1ab4Aa","doi-asserted-by":"crossref","unstructured":"4. A. Pacifico, A. Vidolin, G. Leone and P. Iacovelli, Combined treatment of narrowband ultraviolet B light (NBUVB) phototherapy and oral Polypodium leucotomos extract versus NB UVB phototherapy alone in the treatment of patients with vitiligo, J. Am. Acad. Dermatol.60 (2009) AB154; https:\/\/doi.org\/10.1016\/j.jaad.2008.11.67610.1016\/j.jaad.2008.11.676","DOI":"10.1016\/j.jaad.2008.11.676"},{"key":"2026051108212250796_j_acph-2019-0045_ref_005_w2aab2b8c13b1b7b1ab1ab5Aa","doi-asserted-by":"crossref","unstructured":"5. E. Reyes, P. Jaen, E. de las Heras, F. Carrion, M. Alvarez-Mon, E. de Eusebio, M. Alvare, J. Cuevas, S. Gonz\u00e1lez and V. G. Villarrubia, Systemic immunomodulatory effects of Polypodium leucotomos as an adjuvant to PUVA therapy in generalized vitiligo: a pilot study, J. Dermatol. Sci.41 (2006) 213\u2013216; https:\/\/doi.org\/10.1016\/j.jdermsci.2005.12.00610.1016\/j.jdermsci.2005.12.00616423508","DOI":"10.1016\/j.jdermsci.2005.12.006"},{"key":"2026051108212250796_j_acph-2019-0045_ref_006_w2aab2b8c13b1b7b1ab1ab6Aa","doi-asserted-by":"crossref","unstructured":"6. M. A. Middelkamp-Hup, M. A. Pathak, C. Parrado, D. Goukassian, F. Rius-Diaz, M. C. Mihm, T. B. Fitzpatrick, and S. Gonz\u00e1lez, Oral Polypodium leucotomos extract decreases ultraviolet-induced damage of human skin, J. Am. Acad. Dermatol.51 (2004) 910\u2013918; https:\/\/doi.org\/10.1016\/j.jaad.2004.06.02710.1016\/j.jaad.2004.06.02715583582","DOI":"10.1016\/j.jaad.2004.06.027"},{"key":"2026051108212250796_j_acph-2019-0045_ref_007_w2aab2b8c13b1b7b1ab1ab7Aa","doi-asserted-by":"crossref","unstructured":"7. P. D. Shenefelt, Herbal Treatment for Dermatologic Disorders, in Herbal Medicine: Biomolecular and Clinical Aspects, 2nd ed., CRC Press\/Taylor & Francis, Boca Raton (FL) 2011, Chapter 18.10.1201\/b10787-19","DOI":"10.1201\/b10787-19"},{"key":"2026051108212250796_j_acph-2019-0045_ref_008_w2aab2b8c13b1b7b1ab1ab8Aa","doi-asserted-by":"crossref","unstructured":"8. I. C. Hey, M. Jamieson and A. D. Ormerod, Randomized trial of aromatherapy, Arch. Dermatol.134 (1998) 1349\u20131352.10.1001\/archderm.134.11.1349","DOI":"10.1001\/archderm.134.11.1349"},{"key":"2026051108212250796_j_acph-2019-0045_ref_009_w2aab2b8c13b1b7b1ab1ab9Aa","unstructured":"9. Y. Panahi, M. Taghizadeh, E. T. Marzony and A. Sahebkar, Rosemary oil vs minoxidil 2% for the treatment of androgenetic alopecia: a randomized comparative trial, Skinmed.13 (2015) 15\u201321."},{"key":"2026051108212250796_j_acph-2019-0045_ref_010_w2aab2b8c13b1b7b1ab1ac10Aa","doi-asserted-by":"crossref","unstructured":"10. M. Y. Dhariwala and P. Ravikumar, An overview of herbal alternatives in androgenetic alopecia, J. Cosmet. Dermatol. (2019); https:\/\/doi.org\/10.1111\/jocd.1293010.1111\/jocd.1293030980598","DOI":"10.1111\/jocd.12930"},{"key":"2026051108212250796_j_acph-2019-0045_ref_011_w2aab2b8c13b1b7b1ab1ac11Aa","doi-asserted-by":"crossref","unstructured":"11. B. Y. Choi, Hair-growth potential of ginseng and its major metabolites: A review on its molecular mechanisms, Int. J. Mol. Sci.19 (2018) E2703; https:\/\/doi.org\/10.3390\/ijms1909270310.3390\/ijms19092703616320130208587","DOI":"10.3390\/ijms19092703"},{"key":"2026051108212250796_j_acph-2019-0045_ref_012_w2aab2b8c13b1b7b1ab1ac12Aa","doi-asserted-by":"crossref","unstructured":"12. H. J. Ryu, M. G. Yoo and S. W. Son, The efficacy of 3% minoxidil vs. combined 3% minoxidil and Korean red ginseng in treating female pattern alopecia, Int. J. Dermatol.53 (2014) 340\u2013342; https:\/\/doi.org\/10.1111\/ijd.1235910.1111\/ijd.1235924451023","DOI":"10.1111\/ijd.12359"},{"key":"2026051108212250796_j_acph-2019-0045_ref_013_w2aab2b8c13b1b7b1ab1ac13Aa","doi-asserted-by":"crossref","unstructured":"13. K. E. Sharquie and H. K. Al-Obaidi, Onion juice (Allium cepa L.), a new topical treatment for alopecia areata, J. Dermatol.29 (2002) 343\u2013346; https:\/\/doi.org\/10.1111\/j.1346-8138.2002.tb00277.x10.1111\/j.1346-8138.2002.tb00277.x","DOI":"10.1111\/j.1346-8138.2002.tb00277.x"},{"key":"2026051108212250796_j_acph-2019-0045_ref_014_w2aab2b8c13b1b7b1ab1ac14Aa","doi-asserted-by":"crossref","unstructured":"14. B. Farahnik, D. Sharma, J. Alban and R. K. Sivamani, Topical Botanical Agents for the Treatment of Psoriasis: A Systematic Review, Am. J. Clin. Dermatol.18 (2017) 451\u2013468; https:\/\/doi.org\/10.1007\/s40257-017-0266-010.1007\/s40257-017-0266-0","DOI":"10.1007\/s40257-017-0266-0"},{"key":"2026051108212250796_j_acph-2019-0045_ref_015_w2aab2b8c13b1b7b1ab1ac15Aa","doi-asserted-by":"crossref","unstructured":"15. M. H. Radha and N. P. Laxmipriya, Evaluation of biological properties and clinical effectiveness of Aloe vera: A systematic review, J. Tradit. Complement. Med.5 (2015) 21\u201326; https:\/\/doi.org\/10.1016\/j.jtcme.2014.10.00610.1016\/j.jtcme.2014.10.006","DOI":"10.1016\/j.jtcme.2014.10.006"},{"key":"2026051108212250796_j_acph-2019-0045_ref_016_w2aab2b8c13b1b7b1ab1ac16Aa","doi-asserted-by":"crossref","unstructured":"16. T. A. Syed, S. A. Ahmad, A. H. Holt, S. H. Ahmad and M. Azfal, Management of psoriasis with Aloe vera extract in a hydrophilic cream: a placebo-controlled, double-blind study, Trop. Med. Int. Health1 (1996) 505\u2013509.10.1046\/j.1365-3156.1996.d01-91.x","DOI":"10.1046\/j.1365-3156.1996.d01-91.x"},{"key":"2026051108212250796_j_acph-2019-0045_ref_017_w2aab2b8c13b1b7b1ab1ac17Aa","doi-asserted-by":"crossref","unstructured":"17. Y. J. Surh, S. H. Seoung, Y. S. Keum, H. J. Seo and S. L. Sang, Inhibitory effects of curcumin and capsaicin on phorbol ester-induced activation of eukaryotic transcription factors, NF-\u03baB and AP-1, Biofactors.12 (2000) 107\u2013112.10.1002\/biof.5520120117","DOI":"10.1002\/biof.5520120117"},{"key":"2026051108212250796_j_acph-2019-0045_ref_018_w2aab2b8c13b1b7b1ab1ac18Aa","doi-asserted-by":"crossref","unstructured":"18. J. E. Bernstein, L. C. Parish, M. Rapaport, M. M, Rosenbaum and H. H. Jr. Roenigk, Effects of topically applied capsaicin on moderate and severe psoriasis vulgaris, J. Am. Acad. Dermatol.14 (1986) 504\u2013507.10.1016\/S0190-9622(86)70201-6","DOI":"10.1016\/S0190-9622(86)70201-6"},{"key":"2026051108212250796_j_acph-2019-0045_ref_019_w2aab2b8c13b1b7b1ab1ac19Aa","doi-asserted-by":"crossref","unstructured":"19. C. N. Ellis, B. Berberian, V. I. Sulica, W. A. Dodd, M. T. Jarratt, H. I. Katz, S. Prawer, G. Krueger, I. H. Jr. Rex and J. E. Wolf, A double-blind evaluation of topical capsaicin in pruritic psoriasis, J. Am. Acad. Dermatol.29 (1993) 438\u2013442.10.1016\/0190-9622(93)70208-B","DOI":"10.1016\/0190-9622(93)70208-B"},{"key":"2026051108212250796_j_acph-2019-0045_ref_020_w2aab2b8c13b1b7b1ab1ac20Aa","doi-asserted-by":"crossref","unstructured":"20. H. M. Cheng, Y. C. Wu, Q. Wang, M. Song, J. Wu, D. Chen, K. Li, E. Wadman, S-T. Kao, T-C. Li, F. Leon, K. Hayden, C. Brodmerkel and C. C. Huang, Clinical efficacy and IL-17 targeting mechanism of Indigo naturalis as a topical agent in moderate psoriasis, BMC Complement Altern Med.17 (2017) 439; https:\/\/doi.org\/10.1186\/s12906-017-1947-110.1186\/s12906-017-1947-1558140728865459","DOI":"10.1186\/s12906-017-1947-1"},{"key":"2026051108212250796_j_acph-2019-0045_ref_021_w2aab2b8c13b1b7b1ab1ac21Aa","doi-asserted-by":"crossref","unstructured":"21. Y. K. Lin, W. R. Wong, Y. C. Chang, C. J. Chang, P. K. Tsay, S. C. Chang and J. H. Pang, The efficacy and safety of topically applied indigo naturalis ointment in patients with plaque-type psoriasis, Dermatology.214 (2007) 155\u2013161; https:\/\/doi.org\/10.1159\/00009857610.1159\/00009857617341866","DOI":"10.1159\/000098576"},{"key":"2026051108212250796_j_acph-2019-0045_ref_022_w2aab2b8c13b1b7b1ab1ac22Aa","doi-asserted-by":"crossref","unstructured":"22. Y. K. Lin, C. J. Chang, Y. C. Chang, W. R. Wong, S. C. Chang and J. H. Pang, Clinical assessment of patients with recalcitrant psoriasis in a randomized, observerblind, vehicle-controlled trial using indigo naturalis, Arch. Dermatol.144 (2008) 1457\u20131464; https:\/\/doi.org\/10.1001\/archderm.144.11.145710.1001\/archderm.144.11.145719015420","DOI":"10.1001\/archderm.144.11.1457"},{"key":"2026051108212250796_j_acph-2019-0045_ref_023_w2aab2b8c13b1b7b1ab1ac23Aa","doi-asserted-by":"crossref","unstructured":"23. Y. K. Lin, L. C. See, Y. H. Huang, Y. C. Chang, T. C. Tsou, T. Y. Lin and N. L. Lin, Efficacy and safety of Indigo naturalis extract in oil (Lindioil) in treating nail psoriasis: a randomized, observer-blind, vehicle-controlled trial, Phytomedicine21 (2014) 1015\u20131020; https:\/\/doi.org\/10.1016\/j.phymed.2014.02.01310.1016\/j.phymed.2014.02.01324680615","DOI":"10.1016\/j.phymed.2014.02.013"},{"key":"2026051108212250796_j_acph-2019-0045_ref_024_w2aab2b8c13b1b7b1ab1ac24Aa","doi-asserted-by":"crossref","unstructured":"24. S. Bernstein, H. Donsky, W. Gulliver, D. Hamilton, S. Nobel and R. Norman, Treatment of mild to moderate psoriasis with Relieva, a Mahonia aquifolium extract: a double-blind, placebo-controlled study, Am. J. Ther.13 (2006) 121\u2013126.10.1097\/00045391-200603000-00007","DOI":"10.1097\/00045391-200603000-00007"},{"key":"2026051108212250796_j_acph-2019-0045_ref_025_w2aab2b8c13b1b7b1ab1ac25Aa","doi-asserted-by":"crossref","unstructured":"25. S. M. Meltzer, B. J. Monk and K. S. Tewari, Green tea catechins for treatment of external genital warts, Am. J. Obstet. Gynecol.200 (2009); https:\/\/doi.org\/10.1016\/j.ajog.2008.07.06410.1016\/j.ajog.2008.07.06419019336","DOI":"10.1016\/j.ajog.2008.07.064"},{"key":"2026051108212250796_j_acph-2019-0045_ref_026_w2aab2b8c13b1b7b1ab1ac26Aa","doi-asserted-by":"crossref","unstructured":"26. C. S. Yang and H. Wang, Cancer Preventive Activities of Tea Catechins, Molecules21 (2016); https:\/\/doi.org\/10.3390\/molecules2112167910.3390\/molecules21121679627364227941682","DOI":"10.3390\/molecules21121679"},{"key":"2026051108212250796_j_acph-2019-0045_ref_027_w2aab2b8c13b1b7b1ab1ac27Aa","unstructured":"27. A. K. Gupta and D. Daigle, Sinecatechins 10% ointment: a green tea extract for the treatment of external genital warts, Skin Therapy Lett.20 (2015) 6\u20138."},{"key":"2026051108212250796_j_acph-2019-0045_ref_028_w2aab2b8c13b1b7b1ab1ac28Aa","doi-asserted-by":"crossref","unstructured":"28. S. Colantonio and J. K. Rivers, Botanicals with dsermatologic properties derived from first nations gealing: Part 2-plants and algae, J. Cutan. Med. Surg.21 (2017) 299\u2013307; https:\/\/doi.org\/10.1177\/120347541668339010.1177\/120347541668339028300437","DOI":"10.1177\/1203475416683390"},{"key":"2026051108212250796_j_acph-2019-0045_ref_029_w2aab2b8c13b1b7b1ab1ac29Aa","doi-asserted-by":"crossref","unstructured":"29. N. Sharma, S. Sharma and C. Singhal, A comparative study of liquid nitrogen cryotherapy as monotherapy versus in combination with podophyllin in the treatment of condyloma acuminata, J. Clin. Diagn. Res.11 (2017) WC01-WC05; https:\/\/doi.org\/10.7860\/JCDR\/2017\/23797.933910.7860\/JCDR\/2017\/23797.9339542741328511487","DOI":"10.7860\/JCDR\/2017\/23797.9339"}],"container-title":["Acta Pharmaceutica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/content.sciendo.com\/view\/journals\/acph\/69\/4\/article-p525.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/reference-global.com\/pdf\/10.2478\/acph-2019-0045","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T08:52:29Z","timestamp":1778489549000},"score":1,"resource":{"primary":{"URL":"https:\/\/reference-global.com\/article\/10.2478\/acph-2019-0045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,21]]},"references-count":29,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,10,21]]},"published-print":{"date-parts":[[2019,12,1]]}},"alternative-id":["10.2478\/acph-2019-0045"],"URL":"https:\/\/doi.org\/10.2478\/acph-2019-0045","relation":{},"ISSN":["1846-9558"],"issn-type":[{"value":"1846-9558","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,21]]}}}