{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T09:11:27Z","timestamp":1778490687697,"version":"3.51.4"},"reference-count":22,"publisher":"Walter de Gruyter GmbH","issue":"4","license":[{"start":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T00:00:00Z","timestamp":1571616000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This observational clinical study was composed of two substudies: a non-comparative one (\n                    <jats:italic>n<\/jats:italic>\n                    = 166), testing only lysozyme-based compounds (LBCs), and a comparative substudy (\n                    <jats:italic>n<\/jats:italic>\n                    = 275), testing both LBCs and bicarbonate-based local compounds (BBCs) on the healing of oral mucositis during radio- or chemotherapy. The density of ulcerations has decreased significantly after the treatment with lysozyme in both substudies. The density of ulcerations in the radiotherapy group was lower in patients treated with LBCs compared to patients treated with BBCs (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001). In the chemotherapy group, reduction of ulceration density was similar with both LBCs and BBCs. The LBCs reduced pain intensity during the intake of solid food and speech more than BBCs in both patient cohorts (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). In the radiotherapy cohort, pain intensity when consuming liquid foods was reduced more with LBCs than with BBCs (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). No adverse events were recorded. This study demonstrates the advantages of treating oral mucositis during radiotherapy or chemo-therapy with LBCs.\n                  <\/jats:p>","DOI":"10.2478\/acph-2019-0053","type":"journal-article","created":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T05:03:17Z","timestamp":1571720597000},"page":"695-704","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy and safety of local lysozyme treatment in patients with oral mucositis after chemotherapy and radiotherapy"],"prefix":"10.2478","volume":"69","author":[{"given":"Dzenana","family":"Eminagi\u0107","sequence":"first","affiliation":[{"name":"Clinical Center University of Sarajevo Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aida","family":"Lokvan\u010di\u0107","sequence":"additional","affiliation":[{"name":"Bosnalijek JSC , Sarajevo , Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berisa","family":"Hasanbegovi\u0107","sequence":"additional","affiliation":[{"name":"Clinical Center University of Sarajevo Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alma","family":"Meki\u0107-Abazovi\u0107","sequence":"additional","affiliation":[{"name":"Zenica Cantonal Hospital , Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asmir","family":"Avdi\u010devi\u0107","sequence":"additional","affiliation":[{"name":"University Clinical Center Tuzla , Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inga","family":"Marijanovi\u0107","sequence":"additional","affiliation":[{"name":"University Hospital Mostar , Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Slobodan M.","family":"Jankovi\u0107","sequence":"additional","affiliation":[{"name":"University of Kragujevac , Faculty of Medical Sciences , Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Belma","family":"Kapo","sequence":"additional","affiliation":[{"name":"Bosnalijek JSC , Sarajevo , Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2019,10,21]]},"reference":[{"key":"2026051108212312483_j_acph-2019-0053_ref_001_w2aab2b8c29b1b7b1ab1ab1Aa","doi-asserted-by":"crossref","unstructured":"1. Y. Kwon, Mechanism-based management for mucositis: option for treating side effects without compromising the efficacy of cancer therapy, OncoTargets Ther.9 (2016) 2007\u20132016; https:\/\/doi.org\/10.2147\/OTT.S9689910.2147\/OTT.S96899482789427103826","DOI":"10.2147\/OTT.S96899"},{"key":"2026051108212312483_j_acph-2019-0053_ref_002_w2aab2b8c29b1b7b1ab1ab2Aa","doi-asserted-by":"crossref","unstructured":"2. B. Lon\u010dar Brzak and M. Mravak Stipeti\u0107, Scales for the assessment of oral mucositis, Medix20 (2014) 213\u2013216.10.1155\/2014\/746874","DOI":"10.1155\/2014\/746874"},{"key":"2026051108212312483_j_acph-2019-0053_ref_003_w2aab2b8c29b1b7b1ab1ab3Aa","unstructured":"3. M. Muhvi\u0107 Urek, I. Gla\u017ear, A. Braut, and S. Pezelj-Ribari\u0107, Radiation induced oral mucositis \u2013 therapeutic strategy in a case report, Med. Flum.51 (2015) 310\u2013317."},{"key":"2026051108212312483_j_acph-2019-0053_ref_004_w2aab2b8c29b1b7b1ab1ab4Aa","doi-asserted-by":"crossref","unstructured":"4. D. I. Rosenthal and A. Trotti, Strategies for managing radiation-induced mucositis in head and neck cancer, Semin. Radiat. Oncol.19 (2009) 29\u201334; https:\/\/doi.org\/10.1016\/j.semradonc.2008.09.00610.1016\/j.semradonc.2008.09.00619028343","DOI":"10.1016\/j.semradonc.2008.09.006"},{"key":"2026051108212312483_j_acph-2019-0053_ref_005_w2aab2b8c29b1b7b1ab1ab5Aa","doi-asserted-by":"crossref","unstructured":"5. P. Franco, S. Martini, J. Di Muzio, C. Cavallin, F. Arcadipane, M. Rampino, O. Ostellino, G. Pecorari, P. G. Demo, M. Fasolis and M. Airoldi, Prospective assessment of oral mucositis and its impact on quality of life and patient-reported outcomes during radiotherapy for head and neck cancer, Med. 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