{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T18:40:35Z","timestamp":1789065635573,"version":"build-2803163510"},"reference-count":20,"publisher":"Walter de Gruyter GmbH","issue":"3","license":[{"start":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T00:00:00Z","timestamp":1581897600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The aim of this study was to compare the effects of acute (a single injection) and chronic (21 consecutive days) treatments with chrysin 2, 4, and 8 \u03bcmol kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    on anxiety-like behavior and Fos immunoreactivity in the lateral septum nucleus (LSN), a structure that is involved in the regulation of anxiety, in male Wistar rats. These effects were compared with the clinically effective anxiolytic diazepam 7 \u03bcmol kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    . The results showed that acute, but not chronic treatment, with 4 \u03bcmol kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    chrysin exerted anxiolytic- and anti- depressant-like effects with these effects being similar to that of diazepam. Also, none of the above-mentioned treatments did alter Fos immunoreactivity in the LSN, but a tendency towards the reduction of this variable was detected with chrysin 4 \u03bcmol kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    and diazepam 7 \u03bcmol kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    . Altogether, results suggest that chrysin exerts anxiolytic-like effects, however, it can produce pharmacological tolerance after repeated use, similar to benzodiazepines.\n                  <\/jats:p>","DOI":"10.2478\/acph-2020-0022","type":"journal-article","created":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T04:25:27Z","timestamp":1582086327000},"page":"387-397","source":"Crossref","is-referenced-by-count":22,"title":["Differential effects of acute and chronic treatment with the flavonoid chrysin on anxiety-like behavior and Fos immunoreactivity in the lateral septal nucleus in rats"],"prefix":"10.2478","volume":"70","author":[{"given":"Le\u00f3n Jes\u00fas","family":"Germ\u00e1n-Ponciano","sequence":"first","affiliation":[{"name":"Programa de Posgrado en Neuroetolog\u00eda Instituto de Neuroetolog\u00eda , Universidad Veracruzana , Xalapa 91190 , Veracruz, M\u00e9xico"},{"name":"Laboratorio de Neurofarmacolog\u00eda Instituto de Neuroetolog\u00eda , Universidad Veracruzana , Xalapa 91190 , Veracruz, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham","family":"Puga-Olgu\u00edn","sequence":"additional","affiliation":[{"name":"Programa de Posgrado en Neuroetolog\u00eda Instituto de Neuroetolog\u00eda , Universidad Veracruzana , Xalapa 91190 , Veracruz, M\u00e9xico"},{"name":"Laboratorio de Neurofarmacolog\u00eda Instituto de Neuroetolog\u00eda , Universidad Veracruzana , Xalapa 91190 , Veracruz, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"De Jes\u00fas Rovirosa-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Instituto de Neuroetolog\u00eda , Universidad Veracruzana , Xalapa 91190 , Veracruz, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Caba","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Biom\u00e9dicas Universidad Veracruzana , Xalapa 91190 Veracruz, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Meza","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Biom\u00e9dicas Universidad Veracruzana , Xalapa 91190 Veracruz, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Francisco","family":"Rodr\u00edguez-Landa","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurofarmacolog\u00eda Instituto de Neuroetolog\u00eda , Universidad Veracruzana , Xalapa 91190 , Veracruz, M\u00e9xico"},{"name":"Facultad de Qu\u00edmica Farmac\u00e9utica Biol\u00f3gica Universidad Veracruzana , Xalapa 91000 Veracruz, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2020,2,17]]},"reference":[{"key":"2026070713030185297_j_acph-2020-0022_ref_001_w2aab2b8b5b1b7b1ab1ab1Aa","doi-asserted-by":"crossref","unstructured":"1. 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