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Herein we investigated the anti-MERS-CoV activity of newly synthesized sixteen halogenated triazole compounds through the inhibition of helicase activity using the FRET assay. All new compounds underwent justification for their target structures\n                    <jats:italic>via<\/jats:italic>\n                    microanalytical and spectral data. SAR studies were performed. Biological results revealed that the most potent compounds were 4-(cyclopent-1-en-3-ylamino)-5-(2-(4-iodophenyl)hydrazinyl)-4\n                    <jats:italic>H<\/jats:italic>\n                    -1,2,4-triazole-3-thiol (\n                    <jats:bold>16<\/jats:bold>\n                    ) and 4-(cyclopent-1-en-3-ylamino)-5-[2-(4-chlorophenyl)hydrazinyl]-4\n                    <jats:italic>H<\/jats:italic>\n                    -1,2,4-triazole-3-thiol (\n                    <jats:bold>12<\/jats:bold>\n                    ).\n                    <jats:italic>In silico<\/jats:italic>\n                    molecular docking of the most potent compounds was performed to the active binding site of MERS-CoV helicase nsp13. Molecular docking results are in agreement with experimental findings.\n                  <\/jats:p>","DOI":"10.2478\/acph-2020-0024","type":"journal-article","created":{"date-parts":[[2020,1,19]],"date-time":"2020-01-19T04:06:38Z","timestamp":1579406798000},"page":"145-159","source":"Crossref","is-referenced-by-count":53,"title":["Design, synthesis and molecular docking of novel triazole derivatives as potential CoV helicase inhibitors"],"prefix":"10.2478","volume":"70","author":[{"given":"Nashwa Hafez","family":"Zaher","sequence":"first","affiliation":[{"name":"Radiation Drug Research Department National Center for Radiation Research and Technology (NCRRT) , Egyptian Atomic Energy Authority (EAEA) , Cairo , Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Ismail","family":"Mostafa","sequence":"additional","affiliation":[{"name":"Department of Pharmacology , College of Veterinary Medicine , Cairo University , Gizah , Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah Yousef","family":"Altaher","sequence":"additional","affiliation":[{"name":"Department of Physiology, Biochemistry and Pharmacology , College of Veterinary Medicine , King Faisal University Alhasa , Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2020,1,16]]},"reference":[{"key":"2026051108202742714_j_acph-2020-0024_ref_001_w2aab2b8b1b1b7b1ab1ab1Aa","doi-asserted-by":"crossref","unstructured":"1. 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