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Sprague Dawley rats in the control and model groups were administered water. Sprague Dawley rats were divided into the low-, middle-, and high-dose amygdalin groups that received 20, 40, and 80 mg kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    amygdalin, respectively. whereas the silymarin group was treated with 50 mg kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    silymarin. The control and model groups were administered water. Liver tissue analysis revealed significantly lower activities of ALT, AST, ALP, SOD, and MDA in the drug-treated groups compared to the model group. Serum analysis revealed significantly lower HYC and C-IV in the middle-dose amygdalin-treated group compared to the model group. The histopathological changes were less severe in the drug-treated groups as observed by the formation of pseudolobuli and decreased collagen fiber deposition. Hepatic fibrosis-related genes were expressed at significantly lower levels in the amygdalin-treated groups than in the model group. Amygdalin from\n                    <jats:italic>A. mongolica<\/jats:italic>\n                    represents a therapeutic candidate for hepatic fibrosis prevention and treatment.\n                  <\/jats:p>","DOI":"10.2478\/acph-2021-0022","type":"journal-article","created":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T21:09:41Z","timestamp":1611349781000},"page":"459-471","source":"Crossref","is-referenced-by-count":8,"title":["Amygdalin isolated from\n                    <i>Amygdalus mongolica<\/i>\n                    protects against hepatic fibrosis in rats"],"prefix":"10.2478","volume":"71","author":[{"given":"Jia","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pharmacy , Baotou Medical College , Baotou, Inner Mongolia China , 014040"},{"name":"Institute of Bioactive Substance and Mongolian Medicine and Chinese Materia Medica , Baotou, Inner Mongolia , China 014040"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pharmacy , Baotou Medical College , Baotou, Inner Mongolia China , 014040"},{"name":"Institute of Bioactive Substance and Mongolian Medicine and Chinese Materia Medica , Baotou, Inner Mongolia , China 014040"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy , Baotou Medical College , Baotou, Inner Mongolia China , 014040"},{"name":"The Third Staff Hospital of Baogang Group , Baotou, Inner Mongolia , China 014010"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peisai","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy , Baotou Medical College , Baotou, Inner Mongolia China , 014040"},{"name":"Hunan University of Medicine , Huaihua Hunan , China , 418000"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quanli","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Bioactive Substance and Mongolian Medicine and Chinese Materia Medica , Baotou, Inner Mongolia , China 014040"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songli","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy , Baotou Medical College , Baotou, Inner Mongolia China , 014040"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2020,12,31]]},"reference":[{"key":"2026051108212850283_j_acph-2021-0022_ref_001_w2aab3b7b3b1b6b1ab1ab1Aa","doi-asserted-by":"crossref","unstructured":"1. 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