{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T12:32:41Z","timestamp":1785241961143,"version":"3.55.0"},"reference-count":60,"publisher":"Walter de Gruyter GmbH","issue":"4","license":[{"start":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T00:00:00Z","timestamp":1666051200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A good therapeutic alliance is relevant for healthcare providers exposed to patients\u2019 suffering, especially since patients and physicians may understand the painful experience differently. Our aim was to explore the impact of therapeutic alliance on analgesic outcomes in a real-world interdisciplinary pain unit (PU). A cross-sectional observational study was conducted on outpatients (\n                    <jats:italic>n<\/jats:italic>\n                    = 69) using opioids on a long-term basis for the treatment of chronic non-cancer pain, where clinical pharmacologists and pharmacists advised patients about their opioid treatment. Responses to the patient-doctor relationship questionnaire (PDRQ), sociodemographic and clinical information (pain level, quality of life and hospital use) were collected, whereas pharmacology data (analgesic prescription, adverse events, and compliance) were obtained from electronic health records. Patients were predominantly middle-aged (75 % women, 72 % retired), experiencing moderate pain (VAS 40\u201370 mm) on average, and under a high morphine equianalgesic dosage (95 \u00b1 88 mg per day, mainly tapentadol or fentanyl). Patients with better PDRQ outcomes, and therefore better therapeutic alliance, showed lower pain intensity than patients with worse PDRQ outcomes (pain intensity: high scores 60 \u00b1 47 mm and medium scores 60 \u00b1 45 mm\n                    <jats:italic>vs<\/jats:italic>\n                    . low scores 80 \u00b1 75 mm,\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.01). Along with this, pain intensity was lower when patients affirmed that, thanks to the health-care providers, they \u201cgained new insight\u201d, \u201cfelt better\u201d, or \u201cfelt content with their doctor\u2019s treatment\u201d. What\u00b4s more, patients who affirmed \u201cI benefit from the treatment\u201d experienced increased pain relief (benefit 40 \u00b1 30\n                    <jats:italic>vs<\/jats:italic>\n                    . non-benefit 19 \u00b1 26 mm,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.010) and improved quality of life (benefit 33 \u00b1 25\n                    <jats:italic>vs<\/jats:italic>\n                    . non-benefit 18 \u00b1 16 mm,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.031). However, there was a percentage of patients who did not fully understand the provided information, which is something to be taken into account to improve in clinical routine. Therapeutic alliance supported by pharmacist experts on pain management can be an effective strategy to improve analgesic outcomes. Further efforts are needed to improve communication strategies for pain management. Future directions of research should include the analysis of the role of the pharmacist in poly-professional consultations as related to the advice of patients about their medication, and the mutual trust with the patients.\n                  <\/jats:p>","DOI":"10.2478\/acph-2022-0035","type":"journal-article","created":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T13:27:47Z","timestamp":1666099667000},"page":"529-545","source":"Crossref","is-referenced-by-count":6,"title":["Therapeutic alliance impact on analgesic outcomes in a real-world clinical setting: An observational study"],"prefix":"10.2478","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4697-2783","authenticated-orcid":false,"given":"Jordi","family":"Barrachina","sequence":"first","affiliation":[{"name":"Neuropharmacology on Pain and Functional Diversity (NED), Alicante Institute for Health and Biomedical Research (ISABIAL) Alicante , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1854-9005","authenticated-orcid":false,"given":"C\u00e9sar","family":"Margarit","sequence":"additional","affiliation":[{"name":"Neuropharmacology on Pain and Functional Diversity (NED), Alicante Institute for Health and Biomedical Research (ISABIAL) Alicante , Spain"},{"name":"Pain Unit, Department of Health of Alicante-General Hospital , Alicante , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1526-2594","authenticated-orcid":false,"given":"Blanca","family":"Andreu","sequence":"additional","affiliation":[{"name":"Occupational Observatory Miguel Hern\u00e1ndez University of Elche , Elche , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7606-9675","authenticated-orcid":false,"given":"Thomas","family":"Zandonai","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology , Paediatrics and Organic Chemistry Miguel Hern\u00e1ndez University of Elche , Elche , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7345-448X","authenticated-orcid":false,"given":"Pura","family":"Ballester","sequence":"additional","affiliation":[{"name":"Neuropharmacology on Pain and Functional Diversity (NED), Alicante Institute for Health and Biomedical Research (ISABIAL) Alicante , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0048-9451","authenticated-orcid":false,"given":"Javier","family":"Muriel","sequence":"additional","affiliation":[{"name":"Neuropharmacology on Pain and Functional Diversity (NED), Alicante Institute for Health and Biomedical Research (ISABIAL) Alicante , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2202-8488","authenticated-orcid":false,"given":"Esperanza","family":"Cutillas","sequence":"additional","affiliation":[{"name":"Occupational Observatory Miguel Hern\u00e1ndez University of Elche , Elche , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2385-3749","authenticated-orcid":false,"given":"Ana M.","family":"Peir\u00f3","sequence":"additional","affiliation":[{"name":"Neuropharmacology on Pain and Functional Diversity (NED), Alicante Institute for Health and Biomedical Research (ISABIAL) Alicante , Spain"},{"name":"Pain Unit, Department of Health of Alicante-General Hospital , Alicante , Spain"},{"name":"Clinical Pharmacology Unit Department of Health of Alicante-General Hospital Alicante , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2022,10,18]]},"reference":[{"key":"2026051108213313655_j_acph-2022-0035_ref_001","doi-asserted-by":"crossref","unstructured":"1. 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