{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:38:43Z","timestamp":1783039123322,"version":"3.54.6"},"reference-count":49,"publisher":"Walter de Gruyter GmbH","issue":"3","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Herein, thermal and non-thermal techniques were used to elucidate the putative physical and chemical interactions between poorly water-soluble\n                    <jats:italic>Kaempferia<\/jats:italic>\n                    methoxyflavones and PEG400\/propylene glycol. Additionally, the biocompatibility of methoxyflavone-glycol solutions was evaluated using Caco-2 cells  whereas the absorptive transport was investigated by measuring the apparent permeability coefficient (\n                    <jats:italic>P<\/jats:italic>\n                    <jats:sub>app<\/jats:sub>\n                    ) of the methoxyflavones and transepithelial electrical resistance (TEER) of the Caco-2 cell monolayer. Data from differential scanning calorimetry, Fourier-transform infrared (FTIR), and proton nuclear magnetic resonance (\n                    <jats:sup>1<\/jats:sup>\n                    H NMR) spectroscopic analysis revealed physico-chemical compatibility between the three methoxyflavones and PEG400\/propylene glycol. Furthermore, PEG400 and propylene glycol solutions of the methoxyflavones were shown to be compatible with Caco-2 cells at pharmacologically effective concentrations.\n                    <jats:italic>In vitro<\/jats:italic>\n                    transport studies across the Caco-2 cell monolayer revealed high\n                    <jats:italic>P<\/jats:italic>\n                    <jats:sub>app<\/jats:sub>\n                    values of 24.07 \u00d7 10\n                    <jats:sup>\u20136<\/jats:sup>\n                    to 19.63 \u00d7 10\n                    <jats:sup>\u20136<\/jats:sup>\n                    cm s\n                    <jats:sup>\u20131<\/jats:sup>\n                    for PEG400 solutions of the methoxyflavones. The TEER values of the Caco-2 cell monolayers indicated that the increased drug transport was partly due to increased tight junction openings, but without compromising the epithelial barrier integrity. The good pharmaceutical and biocompatibility profiles, as well as improved transport of the methoxyflavones in PEG400 and propylene glycol solutions, are suggestive of the worthiness of this approach for further consideration pertaining to the development of these drugs into oral liquid dosage forms.\n                  <\/jats:p>","DOI":"10.2478\/acph-2023-0030","type":"journal-article","created":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T11:27:17Z","timestamp":1694690837000},"page":"385-404","source":"Crossref","is-referenced-by-count":2,"title":["Insights into the formulation properties, biocompatibility, and permeability of poorly water-soluble methoxyflavones with PEG400 and propylene glycol"],"prefix":"10.2478","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3742-9965","authenticated-orcid":false,"given":"Fredrick Nwude","family":"Eze","sequence":"first","affiliation":[{"name":"Drug Delivery System Excellence Center , Faculty of Pharmaceutical Sciences , Prince of Songkla University Hat Yai , Songkhla , Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5703-3677","authenticated-orcid":false,"given":"Chaweewan","family":"Jansakul","sequence":"additional","affiliation":[{"name":"Natural Product Research Centre of Excellence , Prince of Songkla University , Hat Yai , Songkhla Thailand"},{"name":"Faculty of Traditional Thai Medicine , Prince of Songkla University , Hat Yai , Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4772-2276","authenticated-orcid":false,"given":"Teerapol","family":"Srichana","sequence":"additional","affiliation":[{"name":"Drug Delivery System Excellence Center , Faculty of Pharmaceutical Sciences , Prince of Songkla University Hat Yai , Songkhla , Thailand"},{"name":"Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences , Prince of Songkla University Hat Yai , Songkhla , Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2023,9,14]]},"reference":[{"key":"2026051108195678785_j_acph-2023-0030_ref_001","doi-asserted-by":"crossref","unstructured":"D. Chen, H. Li, W. Li, S. Feng and D. Deng, Kaempferia parviflora and its methoxyflavones: Chemistry and biological activities, Evid. Based Complement Alternat. Med. 2018 (2018) Article ID 4057456 (16 pages); https:\/\/doi.org\/10.1155\/2018\/4057456","DOI":"10.1155\/2018\/4057456"},{"key":"2026051108195678785_j_acph-2023-0030_ref_002","doi-asserted-by":"crossref","unstructured":"S. Yoshino, R. Awa, Y. Miyake, I. Fukuhara, H. Sato, T. Ashino, S. Tomita and H. Kuwahara, Daily intake of <em>Kaempferia parviflora<\/em> extract decreases abdominal fat in overweight and pre-obese subjects: a randomized, double-blind, placebo-controlled clinical study, DMSO 11 (2018) 447\u2013458; https:\/\/doi.org\/10.2147\/DMSO.S169925","DOI":"10.2147\/DMSO.S169925"},{"key":"2026051108195678785_j_acph-2023-0030_ref_003","doi-asserted-by":"crossref","unstructured":"C. Mekjaruskul, Y.-T. Yang, M. G. D. Leed, M. P. Sadgrove, M. Jay and B. Sripanidkulchai, Novel formulation strategies for enhancing oral delivery of methoxyflavones in Kaempferia parviflora by SMEDDS or complexation with 2-hydroxypropyl-\u03b2-cyclodextrin, Int. J. Pharm. 445(1-2) (2013) 1\u201311; https:\/\/doi.org\/10.1016\/j.ijpharm.2013.01.052","DOI":"10.1016\/j.ijpharm.2013.01.052"},{"key":"2026051108195678785_j_acph-2023-0030_ref_004","doi-asserted-by":"crossref","unstructured":"P. Chairuk, S. Tubtimsri, C. Jansakul, P. Sriamornsak and Y. Weerapol, Enhancing oral absorption of poorly water-soluble herb (Kaempferia parviflora) extract using self-nanoemulsifying formulation, Pharm. Dev. Technol. 25(3) (2020) 340\u2013350; https:\/\/doi.org\/10.1080\/10837450.2019.1703134","DOI":"10.1080\/10837450.2019.1703134"},{"key":"2026051108195678785_j_acph-2023-0030_ref_005","doi-asserted-by":"crossref","unstructured":"C. Mekjaruskul and B. Sripanidkulchai, Kaempferia parviflora nanosuspension formulation for scalability and improvement of dissolution profiles and intestinal absorption, AAPS PharmSciTech. 21 (2020) Article ID 52; https:\/\/doi.org\/10.1208\/s12249-019-1588-4","DOI":"10.1208\/s12249-019-1588-4"},{"key":"2026051108195678785_j_acph-2023-0030_ref_006","doi-asserted-by":"crossref","unstructured":"Y. Weerapol, S. Tubtimsri, C. Jansakul and P. Sriamornsak, Improved dissolution of Kaempferia parviflora extract for oral administration by preparing solid dispersion via solvent evaporation, Asian J. Pharm. Sci. 12(2) (2017) 124\u2013133; https:\/\/doi.org\/10.1016\/j.ajps.2016.09.005","DOI":"10.1016\/j.ajps.2016.09.005"},{"key":"2026051108195678785_j_acph-2023-0030_ref_007","doi-asserted-by":"crossref","unstructured":"K. Sutthanut, B. Sripanidkulchai, C. Yenjai and M. Jay, Simultaneous identification and quantitation of 11 flavonoid constituents in Kaempferia parviflora by gas chromatography, J. Chrom. A 1143(1-2) (2007) 227\u2013233; https:\/\/doi.org\/10.1016\/j.chroma.2007.01.033","DOI":"10.1016\/j.chroma.2007.01.033"},{"key":"2026051108195678785_j_acph-2023-0030_ref_008","doi-asserted-by":"crossref","unstructured":"N. Koirala, N. H. Thuan, G. P. Ghimire, D. V. Thang and J. K. Sohng, Methylation of flavonoids: Chemical structures, bioactivities, progress and perspectives for biotechnological production, Enzyme Microbial. Tech. 86 (2016) 103\u2013116; https:\/\/doi.org\/10.1016\/j.enzmictec.2016.02.003","DOI":"10.1016\/j.enzmictec.2016.02.003"},{"key":"2026051108195678785_j_acph-2023-0030_ref_009","doi-asserted-by":"crossref","unstructured":"L. Zhang, H. Luan, W. Lu and H. Wang, Preformulation studies and enabling formulation selection for an insoluble compound at preclinical stage \u2013 from in vitro, in silico to in vivo, J. Pharm. Sci. 109 (2020) 950\u2013958; https:\/\/doi.org\/10.1016\/j.xphs.2019.10.023","DOI":"10.1016\/j.xphs.2019.10.023"},{"key":"2026051108195678785_j_acph-2023-0030_ref_010","doi-asserted-by":"crossref","unstructured":"A. Hussain, M. A. Altamimi, O. Afzal, A. S. A. Altamimi, A. Ali, A. Ali, F. Martinez, M. U. Mohd Siddique, W. E. Acree and A. Jouyban, Preferential solvation study of the synthesized aldose reductase inhibitor (SE415) in the {PEG 400 (1) + water (2)} cosolvent mixture and gastroplus-based prediction, ACS Omega 7(1) (2022) 1197\u20131210; https:\/\/doi.org\/10.1021\/acsomega.1c05788","DOI":"10.1021\/acsomega.1c05788"},{"key":"2026051108195678785_j_acph-2023-0030_ref_011","doi-asserted-by":"crossref","unstructured":"S. Kalepu and V. Nekkanti, Insoluble drug delivery strategies: review of recent advances and business prospects, Acta Pharm. Sin. B 5(5) (2015) 442\u2013453; https:\/\/doi.org\/10.1016\/j.apsb.2015.07.003","DOI":"10.1016\/j.apsb.2015.07.003"},{"key":"2026051108195678785_j_acph-2023-0030_ref_012","doi-asserted-by":"crossref","unstructured":"A. A. D\u2019souza and R. Shegokar, Polyethylene glycol (PEG): a versatile polymer for pharmaceutical applications, Expert Opin. Drug Deliv. 13(9) (2016) 1257\u20131275; https:\/\/doi.org\/10.1080\/17425247.2016.1182485","DOI":"10.1080\/17425247.2016.1182485"},{"key":"2026051108195678785_j_acph-2023-0030_ref_013","doi-asserted-by":"crossref","unstructured":"R. P. Gullapalli and C. L. Mazzitelli, Polyethylene glycols in oral and parenteral formulations \u2013 A critical review, Int. J. Pharm. 496(2) (2015) 219\u2013239; https:\/\/doi.org\/10.1016\/j.ijpharm.2015.11.015","DOI":"10.1016\/j.ijpharm.2015.11.015"},{"key":"2026051108195678785_j_acph-2023-0030_ref_014","doi-asserted-by":"crossref","unstructured":"C. Jansakul, K. Tachanaparuksa, M. J. Mulvany and Y. Sukpondma, Relaxant mechanisms of 3,5,7,3\u2019,4\u2019-pentamethoxyflavone on isolated human cavernosum, Eur. J. Pharmacol. 691(1-3) (2012) 235\u2013244; https:\/\/doi.org\/10.1016\/j.ejphar.2012.07.019","DOI":"10.1016\/j.ejphar.2012.07.019"},{"key":"2026051108195678785_j_acph-2023-0030_ref_015","doi-asserted-by":"crossref","unstructured":"S. Yorsin, K. Kanokwiroon, N. Radenahmad and C. Jansakul, Increased vascular eNOS and cystathionine-\u03b3-lyase protein after 6 weeks oral administration of 3,5,7,3\u2019,4\u2019-pentamethoxyflavone to middle-aged male rats, Naunyn-Schmiedeberg\u2018s Arch. Pharmacol. 389 (2016) 1183\u20131194; https:\/\/doi.org\/10.1007\/s00210-016-1280-0","DOI":"10.1007\/s00210-016-1280-0"},{"key":"2026051108195678785_j_acph-2023-0030_ref_016","doi-asserted-by":"crossref","unstructured":"S. Sawatdee, H. Phetmung and T. Srichana, Sildenafil citrate monohydrate-cyclodextrin nanosus-pension complexes for use in metered-dose inhalers, Int. J. Pharm. 455(1-2) (2013) 248\u2013258; https:\/\/doi.org\/10.1016\/j.ijpharm.2013.07.023","DOI":"10.1016\/j.ijpharm.2013.07.023"},{"key":"2026051108195678785_j_acph-2023-0030_ref_017","doi-asserted-by":"crossref","unstructured":"P. B. Rathi, M. Kale, J. Soleymani and A. Jouyban, Solubility of etoricoxib in aqueous solutions of glycerin, methanol, polyethylene glycols 200, 400, 600, and propylene glycol at 298.2 K, J. Chem. Eng. Data 63(2) (2018) 321\u2013330; https:\/\/doi.org\/10.1021\/acs.jced.7b00709","DOI":"10.1021\/acs.jced.7b00709"},{"key":"2026051108195678785_j_acph-2023-0030_ref_018","doi-asserted-by":"crossref","unstructured":"B.-L. Ma, Y. Yang, Y. Dai, Q. Li, G. Lin and Y.-M. Ma, Polyethylene glycol 400 (PEG400) affects the systemic exposure of oral drugs based on multiple mechanisms: taking berberine as an example, RSC Adv. 7 (2017) 2435\u20132442; https:\/\/doi.org\/10.1039\/C6RA26284H","DOI":"10.1039\/C6RA26284H"},{"key":"2026051108195678785_j_acph-2023-0030_ref_019","unstructured":"International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use, ICH Harmonised Tripartite Guideline, Validation of Analytical Procedures: Text and Methodology Q2(R1), Current Step 4 version, November 2005; https:\/\/www.ich.org\/fileadmin\/Public_Web_Site\/ICH_Products\/Guidelines\/Quality\/Q2_R1\/Step4\/Q2_R1__Guideline.pdf last acess date May 16, 2023."},{"key":"2026051108195678785_j_acph-2023-0030_ref_020","doi-asserted-by":"crossref","unstructured":"F. N. Eze and O. F. Nwabor, Valorization of Pichia spent medium via one-pot synthesis of biocompatible silver nanoparticles with potent antioxidant, antimicrobial, tyrosinase inhibitory and reusable catalytic activities, Mater. Sci. Eng. C 115 (2020) Article ID 111104 (14 pages); https:\/\/doi.org\/10.1016\/j.msec.2020.111104","DOI":"10.1016\/j.msec.2020.111104"},{"key":"2026051108195678785_j_acph-2023-0030_ref_021","doi-asserted-by":"crossref","unstructured":"Y. Kamiya, S. Otsuka, T. Miura, H. Takaku, R. Yamada, M. Nakazato, H. Nakamura, S. Mizuno, F. Shono, K. Funatsu and H. Yamazaki, Plasma and hepatic concentrations of chemicals after virtual oral administrations extrapolated using rat plasma data and simple physiologically based pharmacokinetic models, Chem. Res. Toxicol. 32(1) (2019) 211\u2013218; https:\/\/doi.org\/10.1021\/acs.chemrestox.8b00307","DOI":"10.1021\/acs.chemrestox.8b00307"},{"key":"2026051108195678785_j_acph-2023-0030_ref_022","doi-asserted-by":"crossref","unstructured":"R. C. R. Beck, A. R. Pohlmann, C. Hoffmeister, M. R. Gallas, E. Collnot, U. F. Schaefer, S. S. Guterres and C. M. Lehr, Dexamethasone-loaded nanoparticle-coated microparticles: Correlation between in vitro drug release and drug transport across Caco-2 cell monolayers, Eur. J. Pharm. Biopharm. 67(1) (2007) 18\u201330; https:\/\/doi.org\/10.1016\/j.ejpb.2007.01.007","DOI":"10.1016\/j.ejpb.2007.01.007"},{"key":"2026051108195678785_j_acph-2023-0030_ref_023","doi-asserted-by":"crossref","unstructured":"G. Kigen and G. Edwards, Drug-transporter mediated interactions between anthelminthic and anti retroviral drugs across the Caco-2 cell monolayers, BMC Pharmacol. Toxicol. 18 (2017) Article ID 20 (18 pages); https:\/\/doi.org\/10.1186\/s40360-017-0129-6","DOI":"10.1186\/s40360-017-0129-6"},{"key":"2026051108195678785_j_acph-2023-0030_ref_024","doi-asserted-by":"crossref","unstructured":"S. Songngam, M. Sukwattanasinitt, K. Siralertmukul and P. Sawasdee, A 5,7-dimethoxyflavone\/hydroxypropyl-\u03b2-cyclodextrin inclusion complex with anti-butyrylcholinesterase activity, AAPS PharmSciTech. 15 (2014) 1189\u20131196; https:\/\/doi.org\/10.1208\/s12249-014-0157-0","DOI":"10.1208\/s12249-014-0157-0"},{"key":"2026051108195678785_j_acph-2023-0030_ref_025","doi-asserted-by":"crossref","unstructured":"R. Paberit, E. Rilby, J. G\u00f6hl, J. Swenson, Z. Refaa, P. Johansson and H. Jansson, Cycling stability of poly(ethylene glycol) of six molecular weights: Influence of thermal conditions for energy applications, ACS Appl. Energy Mater. 3 (2020) 10578\u201310589; https:\/\/doi.org\/10.1021\/acsaem.0c01621","DOI":"10.1021\/acsaem.0c01621"},{"key":"2026051108195678785_j_acph-2023-0030_ref_026","doi-asserted-by":"crossref","unstructured":"T. Uemura, N. Yanai, S. Watanabe, H. Tanaka, R. Numaguchi, M. T. Miyahara, Y. Ohta, M. Nagaoka and S. Kitagawa, Unveiling thermal transitions of polymers in subnanometre pores, Nat. Commun. 1 (2010) Article ID 83 (8 pages); https:\/\/doi.org\/10.1038\/ncomms1091","DOI":"10.1038\/ncomms1091"},{"key":"2026051108195678785_j_acph-2023-0030_ref_027","doi-asserted-by":"crossref","unstructured":"C. Belingheri, E. Curti, A. Ferrillo and E. Vittadini, Evaluation of porous starch as a flavour carrier, Food Funct. 3 (2012) 255\u2013261; https:\/\/doi.org\/10.1039\/C1FO10184F","DOI":"10.1039\/C1FO10184F"},{"key":"2026051108195678785_j_acph-2023-0030_ref_028","doi-asserted-by":"crossref","unstructured":"H. J. Oh, B. D. Freeman, J. E. McGrath, C. H. Lee and D. R. Paul, Thermal analysis of disulfonated poly(arylene ether sulfone) plasticized with poly(ethylene glycol) for membrane formation, Polymer, Special issue: Porous Polymers 55(1) (2014) 235\u2013247; https:\/\/doi.org\/10.1016\/j.polymer.2013.11.041","DOI":"10.1016\/j.polymer.2013.11.041"},{"key":"2026051108195678785_j_acph-2023-0030_ref_029","doi-asserted-by":"crossref","unstructured":"J. A. Manthey, Fourier transform infrared spectroscopic analysis of the polymethoxylated flavone content of orange oil residues, J. Agric. Food Chem. 54(9) (2006) 3215\u20133218; https:\/\/doi.org\/10.1021\/jf053134a","DOI":"10.1021\/jf053134a"},{"key":"2026051108195678785_j_acph-2023-0030_ref_030","doi-asserted-by":"crossref","unstructured":"I. M. Deygen and \u0415. V. Kudryashova, New versatile approach for analysis of PEG content in conjugates and complexes with biomacromolecules based on FTIR spectroscopy, Colloids Surfaces B: Bio-interfaces 141 (2016) 36\u201343; https:\/\/doi.org\/10.1016\/j.colsurfb.2016.01.030","DOI":"10.1016\/j.colsurfb.2016.01.030"},{"key":"2026051108195678785_j_acph-2023-0030_ref_031","doi-asserted-by":"crossref","unstructured":"K. S. Suganthi, N. Anusha and K. S. Rajan, Low viscous ZnO-propylene glycol nanofluid: a potential coolant candidate, J. Nanopart. Res. 15 (2013) Article ID 1986; https:\/\/doi.org\/10.1007\/s11051-013-1986-6","DOI":"10.1007\/s11051-013-1986-6"},{"key":"2026051108195678785_j_acph-2023-0030_ref_032","doi-asserted-by":"crossref","unstructured":"K. Adhikari, W. Buatong, E. Thawithong, T. Suwandecha and T. Srichana, Factors affecting enhanced permeation of amphotericin B across cell membranes and safety of formulation, AAPS PharmSciTech. 17 (2016) 820\u2013828; https:\/\/doi.org\/10.1208\/s12249-015-0406-x","DOI":"10.1208\/s12249-015-0406-x"},{"key":"2026051108195678785_j_acph-2023-0030_ref_033","doi-asserted-by":"crossref","unstructured":"M. Z. Jora, M. V. C. Cardoso and E. Sabadini, Dynamical aspects of water-poly(ethylene glycol) solutions studied by 1H NMR, J. Mol. Liquids 222 (2016) 94\u2013100; https:\/\/doi.org\/10.1016\/j.molliq.2016.06.101","DOI":"10.1016\/j.molliq.2016.06.101"},{"key":"2026051108195678785_j_acph-2023-0030_ref_034","doi-asserted-by":"crossref","unstructured":"L. L. Tshweu, M. A. Shemis, A. Abdelghany, A. Gouda, L. A. Pilcher, N. R. S. Sibuyi, M. Meyer, A. Dube and M. O. Balogun, Synthesis, physicochemical characterization, toxicity and efficacy of a PEG conjugate and a hybrid PEG conjugate nanoparticle formulation of the antibiotic moxifloxacin, RSC Adv. 34 (2020) 19770\u201319780; https:\/\/doi.org\/10.1039\/C9RA10872F","DOI":"10.1039\/C9RA10872F"},{"key":"2026051108195678785_j_acph-2023-0030_ref_035","doi-asserted-by":"crossref","unstructured":"J. Fattori, F. H. S. Rodrigues, J. G. M. Pontes, A. Paula Esp\u00edndola and L. Tasic, Chapter 6 \u2013 Monitoring Intermolecular and Intramolecular Interactions by NMR Spectroscopy, in Applications of NMR Spectroscopy (Eds. A. ur-Rahman and M. I. Choudhary), Vol. 3, Bentham Science Publishers, Karachi 2015, pp. 180\u2013266; https:\/\/doi.org\/10.1016\/B978-1-68108-063-5.50006-0","DOI":"10.2174\/9781681080628115030008"},{"key":"2026051108195678785_j_acph-2023-0030_ref_036","doi-asserted-by":"crossref","unstructured":"G. Akerlof, Dielectric constants of some organic solvent-water mixtures at various temperatures, J. Am. Chem. Soc. 54(11) (1932) 4125\u20134139; https:\/\/doi.org\/10.1021\/ja01350a001","DOI":"10.1021\/ja01350a001"},{"key":"2026051108195678785_j_acph-2023-0030_ref_037","doi-asserted-by":"crossref","unstructured":"M.-J. Ko, H.-H. Nam and M.-S. Chung, Subcritical water extraction of bioactive compounds from Orostachys japonicus A. Berger (Crassulaceae), Sci. Rep. 10 (2020) Article ID 10890 (10 pages); https:\/\/doi.org\/10.1038\/s41598-020-67508-2","DOI":"10.1038\/s41598-020-67508-2"},{"key":"2026051108195678785_j_acph-2023-0030_ref_038","doi-asserted-by":"crossref","unstructured":"M.-J. Ko, C.-I. Cheigh and M.-S. Chung, Relationship analysis between flavonoids structure and subcritical water extraction (SWE), Food Chem. 143 (2014) 147\u2013155; https:\/\/doi.org\/10.1016\/j.food-chem.2013.07.104","DOI":"10.1016\/j.foodchem.2013.07.104"},{"key":"2026051108195678785_j_acph-2023-0030_ref_039","doi-asserted-by":"crossref","unstructured":"Z. Zhou, Y. Qu, J. Wang, S. Wang, J. Liu and M. Wu, Measurement and correlation of solubilities of (Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetic acid in different pure solvents and binary mixtures of water + (ethanol, methanol, or glycol), J. Chem. Eng. Data 56(4) (2011) 1622\u20131628; https:\/\/doi.org\/10.1021\/je101351w","DOI":"10.1021\/je101351w"},{"key":"2026051108195678785_j_acph-2023-0030_ref_040","doi-asserted-by":"crossref","unstructured":"C. MacDonald, W. Lyzenga, D. Shao and R. U. Agu, Water-soluble organic solubilizers for in vitro drug delivery studies with respiratory epithelial cells: selection based on various toxicity indicators, Drug Deliv. 17 (2010) 434\u2013442; https:\/\/doi.org\/10.3109\/10717541003777548","DOI":"10.3109\/10717541003777548"},{"key":"2026051108195678785_j_acph-2023-0030_ref_041","doi-asserted-by":"crossref","unstructured":"L. Le Hegarat, S. Huet, E. Pasquier and S. Charles, Impact of solvents on the in vitro genotoxicity of TMPTA in human HepG2 cells, Toxicol. In Vitro 69 (2020) Article ID 105003; https:\/\/doi.org\/10.1016\/j.tiv.2020.105003","DOI":"10.1016\/j.tiv.2020.105003"},{"key":"2026051108195678785_j_acph-2023-0030_ref_042","doi-asserted-by":"crossref","unstructured":"H. Li, X. Zhang and W. Wang, Antiancer activity of 5,7-dimethoxyflavone against liver cancer cell line HEPG2 involves apoptosis, ROS generation and cell cycle arrest, Afr. J. Tradit. Complement Altern. Med. 14(4) (2017) 213\u2013220; https:\/\/doi.org\/10.21010\/ajtcam.v14i4.24","DOI":"10.21010\/ajtcam.v14i4.24"},{"key":"2026051108195678785_j_acph-2023-0030_ref_043","doi-asserted-by":"crossref","unstructured":"Y. Miyata, J. Tatsuzaki, J. Yang and H. Kosano, Potential therapeutic agents, polymethoxylated flavones isolated from Kaempferia parviflora for cataract prevention through inhibition of matrix metal-loproteinase-9 in lens epithelial cells, Biol. Pharm. Bull. 42(10) (2019) 1658\u20131664; https:\/\/doi.org\/10.1248\/bpb.b19-00244","DOI":"10.1248\/bpb.b19-00244"},{"key":"2026051108195678785_j_acph-2023-0030_ref_044","doi-asserted-by":"crossref","unstructured":"P. Tep-areenan, P. Sawasdee and M. Randall, Possible mechanisms of vasorelaxation for 5,7-dime-thoxyflavone from Kaempferia parviflora in the rat aorta, Phytother. Res. 24(10) (2010) 1520\u20131525; https:\/\/doi.org\/https:\/\/doi.org\/10.1002\/ptr.3164","DOI":"10.1002\/ptr.3164"},{"key":"2026051108195678785_j_acph-2023-0030_ref_045","doi-asserted-by":"crossref","unstructured":"H. F. Smyth, C. P. Carpenter and C. S. Weil, The chronic oral toxicology of the polyethylene glycols, J. Am. Pharm. Assoc. 44(1) (1955) 27\u201330; https:\/\/doi.org\/10.1002\/jps.3030440111","DOI":"10.1002\/jps.3030440111"},{"key":"2026051108195678785_j_acph-2023-0030_ref_046","doi-asserted-by":"crossref","unstructured":"J. D. R. Schulze, W. A. Waddington, P. J. Eli, G. E. Parsons, M. D. Coffin and A. W. Basit, Concentration-dependent effects of polyethylene glycol 400 on gastrointestinal transit and drug absorption, Pharm. Res. 20 (2003) 1984\u20131988; https:\/\/doi.org\/10.1023\/b:pham.0000008046.64409.bd","DOI":"10.1023\/B:PHAM.0000008046.64409.bd"},{"key":"2026051108195678785_j_acph-2023-0030_ref_047","doi-asserted-by":"crossref","unstructured":"G. L. Amidon, H. Lennern\u00e4s, V. P. Shah and J. R. Crison, A theoretical basis for a biopharmaceutic drug classification: The correlation of in vitro drug product dissolution and in vivo bioavailability, Pharm. Res. 12 (1995) 413\u2013420; https:\/\/doi.org\/10.1023\/A:1016212804288","DOI":"10.1023\/A:1016212804288"},{"key":"2026051108195678785_j_acph-2023-0030_ref_048","doi-asserted-by":"crossref","unstructured":"D. A. Volpe, P. J. Faustino, A. B. Ciavarella, E. B. Asafu-Adjaye, C. D. Ellison, L. X. Yu and A. S. Hussain, Classification of drug permeability with a Caco-2 cell monolayer assay, Clin. Res. Regul. Affairs 24(1) (2007) 39\u201347; https:\/\/doi.org\/10.1080\/10601330701273669","DOI":"10.1080\/10601330701273669"},{"key":"2026051108195678785_j_acph-2023-0030_ref_049","doi-asserted-by":"crossref","unstructured":"X.-L. Liang, J. Zhang, G.-W. Zhao, Z. Li, Y. Luo, Z.-G. Liao and D.-M. Yan, Mechanisms of improvement of intestinal transport of baicalin and puerarin by extracts of Radix Angelicae dahuricae, Phytother. Res. 29(2) (2015) 220\u2013227; https:\/\/doi.org\/10.1002\/ptr.5242","DOI":"10.1002\/ptr.5242"}],"container-title":["Acta Pharmaceutica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/reference-global.com\/pdf\/10.2478\/acph-2023-0030","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T08:32:21Z","timestamp":1778488341000},"score":1,"resource":{"primary":{"URL":"https:\/\/reference-global.com\/article\/10.2478\/acph-2023-0030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,1]]},"references-count":49,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,9,14]]},"published-print":{"date-parts":[[2023,9,1]]}},"alternative-id":["10.2478\/acph-2023-0030"],"URL":"https:\/\/doi.org\/10.2478\/acph-2023-0030","relation":{},"ISSN":["1846-9558"],"issn-type":[{"value":"1846-9558","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,1]]}}}