{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:03:38Z","timestamp":1788998618520,"version":"build-2803163510"},"reference-count":48,"publisher":"Walter de Gruyter GmbH","issue":"4","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The poor prognosis of glioblastoma multiforme, inadequate treatment options, and growing drug resistance urge the need to find new effective agents. Due to the significant anti-cancer potential of harmicens, hybrid compounds which comprise harmine\/\u03b2-carboline and ferrocene moiety, we investigated their antiglioblastoma potential\n                    <jats:italic>in vitro<\/jats:italic>\n                    and mechanism of action (inhibition of DYRK1A, Hsp90, anti-oxidative activity). The results have shown that triazole-type harmicens, namely\n                    <jats:bold>5<\/jats:bold>\n                    , with a ferrocene moiety in C-3 position of the \u03b2-carboline ring (\n                    <jats:italic>IC<\/jats:italic>\n                    <jats:sub>50<\/jats:sub>\n                    = 3.7 \u00b1 0.1 \u00b5mol L\u20131, SI = 12.6) and ., the C-6 substituted harmicene (\n                    <jats:italic>IC<\/jats:italic>\n                    <jats:sub>50<\/jats:sub>\n                    = 7.4 \u00b1 0.5 \u00b5mol L\u20131, SI = 5.8) exert remarkable activity and selectivity against human malignant glioblastoma cell line (U251)\n                    <jats:italic>in vitro<\/jats:italic>\n                    . On the other hand, amide-type harmicens\n                    <jats:bold>10<\/jats:bold>\n                    ,\n                    <jats:bold>12<\/jats:bold>\n                    , and\n                    <jats:bold>14<\/jats:bold>\n                    exhibited strong, but non-selective activity, in the low micro-molar range. Mechanistic studies revealed that among active compounds, amide-type harmicens\n                    <jats:bold>12<\/jats:bold>\n                    and\n                    <jats:bold>14<\/jats:bold>\n                    inhibit DYRK1A and Hsp90 CTD, whereas compound\n                    <jats:bold>14<\/jats:bold>\n                    showed pronounced antioxidative activity. Therefore, the antiproliferative activity of harmicens might be a combination of complex molecular interactions.\n                  <\/jats:p>","DOI":"10.2478\/acph-2024-0033","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T06:29:37Z","timestamp":1731997777000},"page":"595-612","source":"Crossref","is-referenced-by-count":5,"title":["Unveiling the antiglioblastoma potential of harmicens, harmine and ferrocene hybrids"],"prefix":"10.2478","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6282-1148","authenticated-orcid":false,"given":"Goran","family":"Poje","sequence":"first","affiliation":[{"name":"University of Zagreb Faculty of Pharmacy and Biochemistry , , Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8871-6622","authenticated-orcid":false,"given":"Davor","family":"\u0160aki\u0107","sequence":"additional","affiliation":[{"name":"University of Zagreb Faculty of Pharmacy and Biochemistry , , Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4868-4031","authenticated-orcid":false,"given":"Marina","family":"Marinovi\u0107","sequence":"additional","affiliation":[{"name":"University of Zagreb Faculty of Pharmacy and Biochemistry , , Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8881-9448","authenticated-orcid":false,"given":"Jiangyang","family":"You","sequence":"additional","affiliation":[{"name":"Rudjer Bo\u0161kovi\u0107 Institute , , Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3712-7194","authenticated-orcid":false,"given":"Michael","family":"Tarpley","sequence":"additional","affiliation":[{"name":"North Carolina Central University Durham , NC 27707 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6930-4630","authenticated-orcid":false,"given":"Kevin P.","family":"Williams","sequence":"additional","affiliation":[{"name":"North Carolina Central University Durham , NC 27707 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1217-2569","authenticated-orcid":false,"given":"Nikolina","family":"Golub","sequence":"additional","affiliation":[{"name":"University of Zagreb Faculty of Pharmacy and Biochemistry , , Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3370-8163","authenticated-orcid":false,"given":"Jaka","family":"Dernov\u0161ek","sequence":"additional","affiliation":[{"name":"University of Ljubljana, Faculty of Pharmacy , , Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5534-209X","authenticated-orcid":false,"given":"Tihomir","family":"Toma\u0161i\u010d","sequence":"additional","affiliation":[{"name":"University of Ljubljana, Faculty of Pharmacy , , Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1116-4655","authenticated-orcid":false,"given":"Erim","family":"Be\u0161i\u0107","sequence":"additional","affiliation":[{"name":"University of Zagreb Faculty of Pharmacy and Biochemistry , , Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1223-1116","authenticated-orcid":false,"given":"Zrinka","family":"Raji\u0107","sequence":"additional","affiliation":[{"name":"University of Zagreb Faculty of Pharmacy and Biochemistry , , Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,1,9]]},"reference":[{"key":"2026051108215571932_j_acph-2024-0033_ref_001","doi-asserted-by":"crossref","unstructured":"C. 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