{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:53:43Z","timestamp":1790358823324,"version":"4.1.0"},"reference-count":33,"publisher":"Walter de Gruyter GmbH","issue":"4","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The aim of this study was to determine whether there are differences in complete blood count parameters (CBC) and inflammation-related biomarkers, MPV\/PC, PLR, NLR, LWR, LMR, NMR, and LCR, among patients with colorectal carcinoma (CRC) and patients with colorectal adenomas. The study included 155 patients who were divided into two groups according to histopathological analysis \u2013 74 adenomas patients and 81 CRC patients. A routine examination of CBC was conducted on Sysmex XN1000 whereas CRP was measured on Alinity ci-series. Statistical analysis was performed by ROC curve analysis using MedCalc Statistical Software. In CRC patients, hemoglobin concentration, hematocrit, MCV, MCH, and MCHC were lower, while RDW was higher (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001), compared to patients with adenomas. Total leukocyte count (\n                    <jats:italic>p<\/jats:italic>\n                    = 0 .006), absolute neutrophils (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.005), and absolute monocytes (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.007) were lower while relative eosinophils (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.001) and relative basophils (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.001) were higher in CRC patients. Platelet count (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001) was significantly higher and MPV (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.003) was significantly lower in CRC patients. Furthermore, MPV\/PC (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001) was significantly lower and PLR (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001) was significantly higher in CRC. Moreover, Receiver Operating Characteristic (ROC) analysis revealed poor diagnostic accuracy, for all tested parameters (AUC was 0.7 or less). PC, MPV, MPV\/PC, and PLR were significantly different between study groups, but ROC analysis revealed poor diagnostic accuracy. Lower hemo globin levels in CRC patients are possibly due to more frequent and excessive bleeding. Higher levels of basophils and eosinophils in CRC patients are indicators of inflammatory reaction, which is linked to CRC.\n                  <\/jats:p>","DOI":"10.2478\/acph-2024-0036","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T06:49:07Z","timestamp":1731998947000},"page":"739-749","source":"Crossref","is-referenced-by-count":6,"title":["Complete blood count parameters and inflammation-related biomarkers in patients with colorectal carcinoma"],"prefix":"10.2478","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9230-910X","authenticated-orcid":false,"given":"Martha","family":"Kor\u017einek","sequence":"first","affiliation":[{"name":"University of Zagreb Faculty of Pharmacy and Biochemistry Department of Medical Biochemistry and Hematology Zagreb , Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3982-5777","authenticated-orcid":false,"given":"Ivana","family":"\u0106elap","sequence":"additional","affiliation":[{"name":"University of Zagreb Faculty of Pharmacy and Biochemistry Department of Medical Biochemistry and Hematology Zagreb , Croatia"},{"name":"Clinical Hospital Centre Sestre milosrdnice , Department of Clinical Chemistry , , Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2688-1988","authenticated-orcid":false,"given":"Marija","family":"Fabijanec","sequence":"additional","affiliation":[{"name":"University of Zagreb Faculty of Pharmacy and Biochemistry Department of Medical Biochemistry and Hematology Zagreb , Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tena","family":"\u017dani\u0107","sequence":"additional","affiliation":[{"name":"University of Zagreb Faculty of Pharmacy and Biochemistry Department of Medical Biochemistry and Hematology Zagreb , Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5207-4357","authenticated-orcid":false,"given":"Neven","family":"Ljubi\u010di\u0107","sequence":"additional","affiliation":[{"name":"Clinical Hospital Centre Sestre milosrdnice , Department of Gastroenterology and Hepatology Zagreb , Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neven","family":"Bar\u0161i\u0107","sequence":"additional","affiliation":[{"name":"Clinical Hospital Centre Sestre milosrdnice , Department of Gastroenterology and Hepatology Zagreb , Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9106-1604","authenticated-orcid":false,"given":"Donatella","family":"Verbanac","sequence":"additional","affiliation":[{"name":"University of Zagreb Faculty of Pharmacy and Biochemistry Department of Medical Biochemistry and Hematology Zagreb , Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9666-5514","authenticated-orcid":false,"given":"Karmela","family":"Bari\u0161i\u0107","sequence":"additional","affiliation":[{"name":"University of Zagreb Faculty of Pharmacy and Biochemistry Department of Medical Biochemistry and Hematology Zagreb , Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7054-3656","authenticated-orcid":false,"given":"Marija Grdi\u0107","family":"Rajkovi\u0107","sequence":"additional","affiliation":[{"name":"University of Zagreb Faculty of Pharmacy and Biochemistry Department of Medical Biochemistry and Hematology Zagreb , Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,1,9]]},"reference":[{"key":"2026051108215668033_j_acph-2024-0036_ref_001","unstructured":"WHO, WHO global survey on the inclusion of cancer care in health-benefit packages 2020\u20132021; https:\/\/iris.who.int\/bitstream\/handle\/10665\/375828\/9789240088504-eng.pdf?sequence=1"},{"key":"2026051108215668033_j_acph-2024-0036_ref_002","doi-asserted-by":"crossref","unstructured":"A. Alsalman, M. A. Al-Mterin, A. Abu-Dayeh, F. Alloush, K. Murshed and E. Elkord, Associations of complete blood count parameters with disease-free survival in right-and left-sided colorectal cancer patients, J. Pers. Med. 12(5) (2022) Article ID 816 (13 pages); https:\/\/doi.org\/10.3390\/jpm12050816","DOI":"10.3390\/jpm12050816"},{"key":"2026051108215668033_j_acph-2024-0036_ref_003","doi-asserted-by":"crossref","unstructured":"B. Baran, N. Mert Ozupek, N. Yerli Tetik, E. Acar, O. Bekcioglu and Y. Baskin, Difference between left-sided and right-sided colorectal cancer: A focused review of literature, Gastroenterol. Res. 11(4) (2018) 264\u2013273; https:\/\/doi.org\/10.14740\/gr1062w","DOI":"10.14740\/gr1062w"},{"key":"2026051108215668033_j_acph-2024-0036_ref_004","doi-asserted-by":"crossref","unstructured":"H. Zhao, L. Wu, G. Yan, Y. Chen, M. Zhou, Y. Wu and Y. Li, Inflammation and tumor progression: Signaling pathways and targeted intervention, Signal Transduct. Target. Ther. . (2021) Article ID 263 (46 pages); https:\/\/doi.org\/10.1038\/s41392-021-00658-5","DOI":"10.1038\/s41392-021-00658-5"},{"key":"2026051108215668033_j_acph-2024-0036_ref_005","doi-asserted-by":"crossref","unstructured":"I. A. Issa and M. Noureddine, Colorectal cancer screening: An updated review of the available options, World J. Gastroenterol. 23(28) 5086\u20135096; https:\/\/doi.org\/10.3748\/wjg.v23.i28.5086","DOI":"10.3748\/wjg.v23.i28.5086"},{"key":"2026051108215668033_j_acph-2024-0036_ref_006","doi-asserted-by":"crossref","unstructured":"P. S. Virdee, I. R. Marian, A. Mansouri, L. Elhussein, S. Kirtley, T. Holt and J. Birks, The full blood count blood test for colorectal cancer detection: A systematic review, meta-analysis, and critical appraisal, Cancers 12 (2020) Article ID 2348 (37 pages); https:\/\/doi.org\/10.3390\/cancers12092348","DOI":"10.3390\/cancers12092348"},{"key":"2026051108215668033_j_acph-2024-0036_ref_007","doi-asserted-by":"crossref","unstructured":"M. S. Meki\u0107, I. Pedi\u0161i\u0107, H. \u0160obat, V. V. Boras, I. Kirac, L. \u0160tefan\u010di\u0107, M. \u0160ekerija, B. Vrdoljak and D. Vrdoljak, The role of complete blood count parameters in patients with colorectal cancer, Acta Clin. Croat. 57(4) (2018) 624\u2013629; https:\/\/doi.org\/10.20471\/acc.2018.57.04.03","DOI":"10.20471\/acc.2018.57.04.03"},{"key":"2026051108215668033_j_acph-2024-0036_ref_008","doi-asserted-by":"crossref","unstructured":"M. Stojkovic Lalosevic, A. Pavlovic Markovic, S. Stankovic, M. Stojkovic, I. Dimitrijevic, I. Radoman Vujacic, D. Lalic, T. Milovanovic, I. Dumic and Z. Krivokapic, Combined diagnostic efficacy of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) as biomarkers of systemic inflammation in the diagnosis of colorectal cancer, Dis. Markers (2019) Article ID 6036979 (7 pages); https:\/\/doi.org\/10.1155\/2019\/6036979","DOI":"10.1155\/2019\/6036979"},{"key":"2026051108215668033_j_acph-2024-0036_ref_009","doi-asserted-by":"crossref","unstructured":"T. Yamamoto, K. Kawada and K. Obama, Inflammation-related biomarkers for the prediction of prognosis in colorectal cancer patients, Int. J. Mol. Sci. 22(15) (2021) Article ID 8002 (14 pages); https:\/\/doi.org\/10.3390\/ijms22158002","DOI":"10.3390\/ijms22158002"},{"key":"2026051108215668033_j_acph-2024-0036_ref_010","doi-asserted-by":"crossref","unstructured":"W. Jia, L. Yuan, H. Ni, B. Xu and P. Zhao, Prognostic value of platelet-to-lymphocyte ratio, neutro-phil-to-lymphocyte ratio, and lymphocyte-to-white blood cell ratio in colorectal cancer patients who received neoadjuvant chemotherapy, Technol. Cancer Res. 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Galdiero, S. Loffredo, V. Lucarini, G. Marone, F. Mattei, G. Marone and G. Schiavoni, Eosinophils: The unsung heroes in cancer? Oncoimmunology .(2) (2018) Article ID e1393134 (12 pages); https:\/\/doi.org\/10.1080\/2162402X.2017.1393134","DOI":"10.1080\/2162402X.2017.1393134"},{"key":"2026051108215668033_j_acph-2024-0036_ref_028","doi-asserted-by":"crossref","unstructured":"Y. Rosman, T. Hornik-Lurie, K. Meir-Shafrir, I. Lachover-Roth, A. Cohen-Engler, A. Munitz and R. Confino-Cohen, Changes in peripheral blood eosinophils may predict colorectal cancer \u2013 A retrospective study, World Allergy Organization J. 15(10) (2022) Article ID 100696 (8 pages); https:\/\/doi.org\/doi:10.1016\/j.waojou.2022.100696","DOI":"10.1016\/j.waojou.2022.100696"},{"key":"2026051108215668033_j_acph-2024-0036_ref_029","doi-asserted-by":"crossref","unstructured":"J. C. Chan, D. L. Chan, C. I. Diakos, A. Engel, N. Pavlakis, A. Gill and S. J. Clarke, The lymphocyteto-monocyte ratio is a superior predictor of overall survival in comparison to established biomarkers of resectable colorectal cancer, Ann. Surg. 265(3) (2017) 539\u2013546; https:\/\/doi.org\/10.1097\/SLA.0000000000001743.","DOI":"10.1097\/SLA.0000000000001743"},{"key":"2026051108215668033_j_acph-2024-0036_ref_030","doi-asserted-by":"crossref","unstructured":"Y. Li, H. Jia, W. Yu, Y. Xu, X. Li, Q. Li and S. Cai, Nomograms for predicting prognostic value of inflammatory biomarkers in colorectal cancer patients after radical resection, Int. J. Cancer 139(1) (2016) 220\u2013231; https:\/\/doi.org\/10.1002\/ijc.30071","DOI":"10.1002\/ijc.30071"},{"key":"2026051108215668033_j_acph-2024-0036_ref_031","doi-asserted-by":"crossref","unstructured":"Y. Okugawa, Y. Toiyama, A. Yamamoto, T. Shigemori, S. Ide, T. Kitajima, H. Fujikawa, H. Yasuda, J. Hiro, S. Yoshiyama, T. Yokoe, S. Saigusa, K. Tanaka, Y. Shirai, M. Kobayashi, M. Ohi, T. Araki, D. C. McMillan, C. Miki, A. 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