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In this meta-analysis, only the studies that directly compared two treatments (vedolizumab and TNF-\u03b1 inhibitors) to each other (head-to-head approach) were considered. A comprehensive literature search was conducted using the following databases: PubMed, Embase, the Cochrane Library, and Web of Science. The pooled estimates of efficacies and safety were calculated as relative risk (RR) and 95 % confidence interval (CI). The presence of bias in the published material was evaluated using Begg\u2019s test. Sensitivity analysis was used to evaluate the pooled results\u2019 robustness. In total, 32 eligible studies were finally included. Results showed that the efficacy of vedolizumab was superior to TNF-\u03b1 inhibitors in clinical remission [1.26, 95 % CI: 1.15\u20131.39]. Moreover, the vedolizumab group showed a reduced incidence of severe adverse events (RR = 0.63, 95 % CI: 0.42\u20130.94) compared to TNF-\u03b1 inhibitors. Our results revealed superior efficacy and safety of vedolizumab compared to TNF-\u03b1 inhibitors, which provided direct evidence for the use of vedolizumab in IBD treatment. Future studies are needed to confirm our findings.<\/jats:p>","DOI":"10.2478\/acph-2025-0004","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T20:19:43Z","timestamp":1741724383000},"page":"23-40","source":"Crossref","is-referenced-by-count":0,"title":["Comparative efficacy and safety of vedolizumab and antitumor necrosis factor alfa in patients with inflammatory bowel diseases: A meta\u2011analysis"],"prefix":"10.2478","volume":"75","author":[{"given":"Yafang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology , The Affiliated Jinhua Hospital Zhejiang University School of Medicine , Jinhua P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5333-3557","authenticated-orcid":false,"given":"Jin","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology , The Affiliated Jinhua Hospital Zhejiang University School of Medicine , Jinhua P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology , The Affiliated Jinhua Hospital Zhejiang University School of Medicine , Jinhua P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiping","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology , The Affiliated Jinhua Hospital Zhejiang University School of Medicine , Jinhua P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3580-4022","authenticated-orcid":false,"given":"Qunying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology , The Affiliated Jinhua Hospital Zhejiang University School of Medicine , Jinhua P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,4,10]]},"reference":[{"key":"2026070421591127018_j_acph-2025-0004_ref_001","doi-asserted-by":"crossref","unstructured":"J. Torres, S. Mehandru, J. F. Colombel and L. Peyrin-Biroulet, Crohn\u2019s disease, Lancet 389(10080) (2017) 1741\u20131755; https:\/\/doi.org\/10.1016\/s0140-6736(16)31711-1","DOI":"10.1016\/S0140-6736(16)31711-1"},{"key":"2026070421591127018_j_acph-2025-0004_ref_002","doi-asserted-by":"crossref","unstructured":"R. Ungaro, S. Mehandru, P. B. Allen, L. Peyrin-Biroulet and J. F. 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