{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T14:51:45Z","timestamp":1780325505551,"version":"3.54.1"},"reference-count":42,"publisher":"Walter de Gruyter GmbH","issue":"3","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The aim of this study was to investigate the potential antidepressant-like effect of combined subthreshold and effective doses of chrysin and fluoxetine in adult male Wistar rats and their potential effects on the serotonergic and noradrenergic systems. Seventy rats were divided into seven experimental groups: vehicle (10 % dimethyl sulfoxide solution, DMSO), chrysin (4 or 20 \u00b5mol kg\n                    <jats:sup>\u20131<\/jats:sup>\n                    ), fluoxetine (1.6 and 3.2 \u00b5mol kg\n                    <jats:sup>\u20131<\/jats:sup>\n                    ), and their combinations. The treatments were administered for 28 consecutive days, and the effects were evaluated in the locomotor activity test (LAT) and forced swim test (FST). The results showed that the treatments did not significantly affect crossings in the LAT. Chrysin, alone or combined, reduced immobility time, increased latency to first immobility and prolonged swimming in the FST, similar to fluoxetine. However, only chrysin (20 \u00b5mol kg\n                    <jats:sup>\u20131<\/jats:sup>\n                    ) and its combination with fluoxetine (1.6 \u00b5mol kg\n                    <jats:sup>\u20131<\/jats:sup>\n                    ) enhanced climbing behaviour in the FST. Chrysin showed an anti-depressant effect, possibly related to enhanced serotonergic and noradrenergic neurotransmission, by increasing climbing and swimming time in the FST. This dual effect suggests a promising antidepressant prototype with different mechanisms of action, allow ing the use of subthreshold doses, which could reduce side effects.\n                  <\/jats:p>","DOI":"10.2478\/acph-2025-0029","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T10:51:54Z","timestamp":1760093514000},"page":"505-516","source":"Crossref","is-referenced-by-count":1,"title":["Chrysin enhances serotonergic and noradrenergic neurotransmission associated with antidepressant effects: A pharmacological study"],"prefix":"10.2478","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0753-0069","authenticated-orcid":false,"given":"Gilberto-Uriel","family":"Rosas-S\u00e1nchez","sequence":"first","affiliation":[{"name":"Programa de Estancias Posdoctorales por M\u00e9xico, Secretar\u00eda de Ciencia, Humanidades Tecnolog\u00eda e Innovaci\u00f3n SECIHTI, Centro Universitario de Los Lagos, Universidad de Guadalajara, Lagos de Moreno 47460 Jalisco , M\u00e9xico"},{"name":"Laboratorio de Neuroinmunofarmacolog\u00eda\/\u00c1rea Neurobiolog\u00eda Celular y Molecular Departamento de Ciencias de la Tierra y de la Vida, Centro Universitario de Los Lagos Universidad de Guadalajara, Lagos de Moreno 47460, Jalisco , M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9185-2900","authenticated-orcid":false,"given":"Le\u00f3n Jes\u00fas","family":"Germ\u00e1n-Ponciano","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurofarmacolog\u00eda Instituto de Neuroetolog\u00eda, Universidad Veracruzana, Xalapa 91190, Veracruz M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5837-103X","authenticated-orcid":false,"given":"Juan Francisco","family":"Rodr\u00edguez-Landa","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurofarmacolog\u00eda Instituto de Neuroetolog\u00eda, Universidad Veracruzana, Xalapa 91190, Veracruz M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0177-3921","authenticated-orcid":false,"given":"\u00c1ngel Alberto","family":"Puig-Lagunes","sequence":"additional","affiliation":[{"name":"Facultad de Medicina , Universidad Veracruzana , Minatitl\u00e1n , M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7829-6222","authenticated-orcid":false,"given":"C\u00e9sar","family":"Soria-Fregozo","sequence":"additional","affiliation":[{"name":"Laboratorio de Neuroinmunofarmacolog\u00eda\/\u00c1rea Neurobiolog\u00eda Celular y Molecular Departamento de Ciencias de la Tierra y de la Vida, Centro Universitario de Los Lagos Universidad de Guadalajara, Lagos de Moreno 47460, Jalisco , M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,10,10]]},"reference":[{"key":"2026051108182276646_j_acph-2025-0029_ref_001","unstructured":"P. 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