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Serum creatinine levels, proteinuria, serum albumin, and total protein concentrations were prospectively recorded for 2 years. The mean levels of AT2R antibodies in the lupus nephropathy group were significantly higher compared to the control group, 64.12 \u00b1 26.95 units\/mL and 9.72 \u00b1 11.88 units\/mL, respectively. There was no association between this level and the clinical course of the disease. The AT2R levels in other kinds of glomerular disease were no different from the control group. We found significant correlations between AT1R and AT2R in patients with membranous nephropathy (r = 0.66), IgA nephropathy (r = 0.61), and c-ANCA vasculitis (r = 0.63). Levels of AT2R antibodies in systemic lupus erythematosus are higher compared to other types of glomerulonephritis, vasculitis, and a healthy control group. Levels of AT2R antibodies correlate with AT1R antibodies in the groups of patients with membranous nephropathy, IgA nephropathy, and c-ANCA vasculitis. These kinds of AT2R antibodies have a stimulative effect on AT2R, but we have not found the influence of these antibodies on the clinical course of glomerular diseases.<\/jats:p>","DOI":"10.2478\/aite-2024-0017","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T04:38:54Z","timestamp":1724042334000},"source":"Crossref","is-referenced-by-count":2,"title":["Angiotensin II Type 2 Receptor Antibodies in Glomerular Diseases"],"prefix":"10.2478","volume":"72","author":[{"given":"Maciej","family":"Szymczak","sequence":"first","affiliation":[{"name":"Department of Nephrology and Transplantation Medicine , Wroclaw Medical University , Wroclaw , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Heidecke","sequence":"additional","affiliation":[{"name":"CellTrend Gmbh , Luckenwalde , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelina","family":"\u017babi\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Transplantation Medicine , Wroclaw Medical University , Wroclaw , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagna","family":"Rukasz","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Transplantation Medicine , Wroclaw Medical University , Wroclaw , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Wi\u015bnicki","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Transplantation Medicine , Wroclaw Medical University , Wroclaw , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Kujawa","sequence":"additional","affiliation":[{"name":"Statistical Analysis Centre , Wroclaw Medical University , Wroclaw , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Ko\u015bcielska-Kasprzak","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Transplantation Medicine , Wroclaw Medical University , Wroclaw , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Krajewska","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Transplantation Medicine , Wroclaw Medical University , Wroclaw , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miros\u0142aw","family":"Banasik","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Transplantation Medicine , Wroclaw Medical University , Wroclaw , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2024,8,19]]},"reference":[{"key":"2026060423391350286_j_aite-2024-0017_ref_001","doi-asserted-by":"crossref","unstructured":"Ali R, Patel S, Hussain T (2021) Angiotensin type 2 receptor activation limits kidney injury during the early phase and induces Treg cells during the late phase of renal ischemia. 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