{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T01:01:14Z","timestamp":1780621274394,"version":"3.54.1"},"reference-count":67,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Vitamin D levels have been related to the severity and progression of various autoimmune disorders. In this study, we aimed to investigate the impact of genetic variability in the vitamin D receptor (VDR) gene on disease susceptibility and progression in patients with rheumatoid arthritis (RA) treated with tumor necrosis factor (TNF) inhibitors. The study comprises 121 RA patients subjected to anti-TNF therapy genotyped for four VDR polymorphic variants: rs1544410 (\n                    <jats:italic>Bsm<\/jats:italic>\n                    I), rs2228570 (\n                    <jats:italic>Fok<\/jats:italic>\n                    I), rs731236 (\n                    <jats:italic>Taq<\/jats:italic>\n                    I), and rs7975232 (\n                    <jats:italic>Apa<\/jats:italic>\n                    I). There was no significant association between RA susceptibility and VDR genetic variants. The study results revealed that patients with the rs2228570\n                    <jats:italic>CC<\/jats:italic>\n                    genotype were characterized by lower vitamin D3 levels (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.028) than those with the\n                    <jats:italic>T<\/jats:italic>\n                    allele. Also, the vitamin D3 levels (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.029) and age at diagnosis (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.017) were significantly lower in rs7975232\n                    <jats:italic>A<\/jats:italic>\n                    allele carriers compared to\n                    <jats:italic>CC<\/jats:italic>\n                    homozygotes. However, after 6 months of therapy, the\n                    <jats:italic>A<\/jats:italic>\n                    allele seemed to be related to lower disease activity score 28 (DAS28) values (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.030) and more common in patients who achieved remission (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.004) compared to the\n                    <jats:italic>CC<\/jats:italic>\n                    genotype. Concerning other investigated polymorphisms, patients carrying rs1544410\n                    <jats:italic>AA<\/jats:italic>\n                    and rs731236\n                    <jats:italic>CC<\/jats:italic>\n                    homozygosity had lower C-reactive protein (CRP) levels before therapy (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.009). In conclusion, VDR rs2228570 and rs7975232 polymorphic variants were found to be related to vitamin D3 levels. Moreover, the genotyping of rs7975232 was also useful in evaluating disease onset and disease activity after 6 months of therapy with TNF inhibitors in RA patients.\n                  <\/jats:p>","DOI":"10.2478\/aite-2024-0023","type":"journal-article","created":{"date-parts":[[2024,11,10]],"date-time":"2024-11-10T10:56:43Z","timestamp":1731236203000},"source":"Crossref","is-referenced-by-count":2,"title":["Polymorphic Variants in the Vitamin D Receptor and Clinical Parameters of Rheumatoid Arthritis Patients Undergoing Anti-TNF Treatment"],"prefix":"10.2478","volume":"72","author":[{"given":"Joanna","family":"Wieli\u0144ska","sequence":"first","affiliation":[{"name":"Department of Clinical Immunology , Laboratory of Clinical Immunogenetics and Pharmacogenetics , Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences , R. Weigla 12 , Wroclaw , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"G\u00f3rna","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology , Laboratory of Clinical Immunogenetics and Pharmacogenetics , Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences , R. Weigla 12 , Wroclaw , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerzy","family":"\u015awierkot","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Internal Medicine , Wroclaw Medical University , Wroclaw , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bartosz","family":"Bugaj","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Internal Medicine , Wroclaw Medical University , Wroclaw , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Kolossa","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Connective Tissue Diseases , Jan Biziel University Hospital No. 2 , Bydgoszcz , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u0142awomir","family":"Jeka","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Connective Tissue Diseases , Jan Biziel University Hospital No. 2 , Bydgoszcz , Poland"},{"name":"Clinic and Department of Rheumatology and Connective Tissue Diseases, Ludwik Rydygier Collegium Medicum in Bydgoszcz , Nicolaus Copernicus University in Torun , Jagiello\u0144ska 15 , Bydgoszcz , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Bogunia-Kubik","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology , Laboratory of Clinical Immunogenetics and Pharmacogenetics , Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences , R. Weigla 12 , Wroclaw , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2024,11,10]]},"reference":[{"key":"2026060500140679095_j_aite-2024-0023_ref_001","doi-asserted-by":"crossref","unstructured":"AbdElneam AI, Al-Dhubaibi MS, Bahaj SS et al (2023) The CDX2 G allele and the FoKI F allele of the VDR gene are more prevalent and related to changes in vitamin D levels in patients with psoriasis vulgaris: A pilot study. Skin Res Technol 29:e13530. https:\/\/doi.org\/10.1111\/srt.13530","DOI":"10.1111\/srt.13530"},{"key":"2026060500140679095_j_aite-2024-0023_ref_002","doi-asserted-by":"crossref","unstructured":"Ahmad HM, Zaki ZM, Mohamed AS et al (2024) Genetic risk of rheumatoid arthritis: A case control study. 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