{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:49:32Z","timestamp":1777855772901,"version":"3.51.4"},"reference-count":20,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study aimed to determine the efficacy of low molecular weight heparin (LMWH) and lidocaine combined with LMWH for improving the course of acute pancreatitis (AP). A total of 30 rats were divided into three groups: the NaCl group, which received an intraarterial infusion of 0.9% sodium chloride; the Heparin group, which received a subcutaneous injection of LMWH; and the Lidocaine\u2013Heparin group, which received an intraarterial infusion of 1% lidocaine, with subsequent subcutaneous injection of LMWH. AP was triggered using 80 \u03bcg\/kg body weight of cerulein. Serum amylase and lipase levels were evaluated before induction of AP (measurement 0 \u2013 M0), after triggering AP (measurement 1 \u2013 M1), 1 h (measurement 2 \u2013 M2), 3 h (measurement 3 \u2013 M3), and 5 h (measurement 4 \u2013 M4) after treatment. After euthanasia, pancreatic tissues were collected for pathological analysis. No intergroup differences in serum amylase and lipase levels were observed between the NaCl and Heparin groups in all post-treatment evaluation points (M2, M3, and M4). Conversely, the Lidocaine\u2013Heparin group showed significantly lower amylase values than the NaCl and Heparin groups in all post-treatment evaluation points. Furthermore, the Lidocaine\u2013Heparin group showed significantly lower lipase values compared with the NaCl group in the first post-treatment evaluation point (M2), as well as compared with the Heparin group in the first (M2) and second (M3) post-treatment evaluation points. No significant intergroup differences were observed in pathological pancreatic tissue evaluation. Subcutaneous injection of LMWH did not impact the natural course of AP. However, the addition of intraarterially administered 1% lidocaine solution significantly reduced the severity of AP.<\/jats:p>","DOI":"10.2478\/aite-2025-0012","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T02:11:36Z","timestamp":1744769496000},"source":"Crossref","is-referenced-by-count":0,"title":["Intraarterial Infusion of Lidocaine is Superior to the Subcutaneous Injection of Low Molecular Weight Heparin for Improving the Course of Cerulein-Induced Acute Pancreatitis in Rats"],"prefix":"10.2478","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1377-1608","authenticated-orcid":false,"given":"Ryszard","family":"Antkowiak","sequence":"first","affiliation":[{"name":"Department of General and Oncologic Surgery , St. Joseph Hospital in Mikolow , Mikolow , Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0145-4680","authenticated-orcid":false,"given":"Lukasz","family":"Antkowiak","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurosurgery , Medical University of Silesia in Katowice , Katowice , Poland"},{"name":"Department of Neurosurgery, St. Barbara Regional Hospital and Trauma Center in Sosnowiec , Medical University of Silesia in Katowice , Sosnowiec , Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5997-2555","authenticated-orcid":false,"given":"Zbigniew","family":"Arent","sequence":"additional","affiliation":[{"name":"Experimental and Innovative Medicine Centre , University of Agriculture , Krakow , Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2287-6842","authenticated-orcid":false,"given":"Bogna","family":"Drozdzowska","sequence":"additional","affiliation":[{"name":"Department of Pathomorphology, Faculty of Medical Sciences in Zabrze , Medical University of Silesia in Katowice , Zabrze , Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5919-5346","authenticated-orcid":false,"given":"Anna","family":"Kasperczuk","sequence":"additional","affiliation":[{"name":"Faculty of Mechanical Engineering, Institute of Biomedical Engineering , Bialystok University of Technology , Bialystok , Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3486-8698","authenticated-orcid":false,"given":"Jacek","family":"Bialecki","sequence":"additional","affiliation":[{"name":"Department of General Minimally Invasive and Trauma Surgery , Francis Raszeja Municipal Hospital , Poznan , Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0251-5097","authenticated-orcid":false,"given":"Agnieszka","family":"Pietsch-Fulbiszewska","sequence":"additional","affiliation":[{"name":"Experimental and Innovative Medicine Centre , University of Agriculture , Krakow , Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1903-0843","authenticated-orcid":false,"given":"Pawel","family":"Domoslawski","sequence":"additional","affiliation":[{"name":"Department of General Gastroenterologic and Endocrine Surgery , Wroclaw Medical University , Wroclaw , Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1111-2967","authenticated-orcid":false,"given":"Agata","family":"Cieslik-Bielecka","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery , St. Barbara Regional Hospital and Trauma Center in Sosnowiec , Sosnowiec , Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7950-679X","authenticated-orcid":false,"given":"Marek","family":"Kucharzewski","sequence":"additional","affiliation":[{"name":"Wladyslaw Bieganski Collegium Medicum , Jan D\u0142ugosz University in Czestochowa , Czestochowa , Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2025,4,16]]},"reference":[{"key":"2026042921034989495_j_aite-2025-0012_ref_001","doi-asserted-by":"crossref","unstructured":"Antkowiak R, Antkowiak \u0141, Grzegorczyn S et al. (2020) Efficacy of intra-arterial lidocaine infusion in the treatment of ceruleininduced acute pancreatitis. Adv Clin Exp Med 29:587\u2013595. https:\/\/doi.org\/10.17219\/acem\/121932","DOI":"10.17219\/acem\/121932"},{"key":"2026042921034989495_j_aite-2025-0012_ref_002","doi-asserted-by":"crossref","unstructured":"Antkowiak R, Bialecki J, Chabowski M et al. (2022) Treatment of microcirculatory disturbances in acute pancreatitis: Where are we now? Pancreas 51:415\u2013421. https:\/\/doi.org\/10.1097\/MPA.0000000000002044","DOI":"10.1097\/MPA.0000000000002044"},{"key":"2026042921034989495_j_aite-2025-0012_ref_003","doi-asserted-by":"crossref","unstructured":"Arsyad A, Dobson GP (2016) Lidocaine relaxation in isolated rat aortic rings is enhanced by endothelial removal: Possible role of Kv, KATP channels and A2a receptor crosstalk. 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