{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T13:48:53Z","timestamp":1784641733567,"version":"3.55.0"},"reference-count":49,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Pyroptosis, a programmed form of inflammatory cell death, has been demonstrated to participate in both Acute pancreatitis (AP) and its complication liver injury. Transgelin-2 (TAGLN2), an actin-binding protein involved in inflammatory response, has been reported to be highly expressed in AP. However, the role of TAGLN2 in AP-induced liver injury remains unclear. Mice were treated with cerulein to construct the AP model\n                    <jats:italic>in vivo<\/jats:italic>\n                    , while Kupffer cells were stimulated with lipopolysaccharide (LPS) to mimic\n                    <jats:italic>in vitro<\/jats:italic>\n                    model. A series of\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    experiments were performed to investigate the role and mechanism of TAGLN2 in AP-induced liver injury. Cerulein administration induced pathological injury of the pancreatic and liver tissues, along with elevated levels of amylase, lipase, alanine aminotransferase (ALT), and aspartate transaminase (AST). TAGLN2 was significantly elevated at both the transcriptional and translational levels in the hepatocytes and Kupffer cells of AP mice. Knockout of TAGLN2 alleviated liver injury by reducing inflammatory cytokine levels, pyroptosis-related protein expression, and liver dysfunction markers. The relative levels of inflammatory factors, the expressions of pyroptosis-related proteins, and the pyroptosis rate were increased in LPS-induced Kupffer cells in an\n                    <jats:italic>in vitro<\/jats:italic>\n                    model, whereas TAGLN2 knockdown reversed these changes. Mechanistically, TAGLN2 promoted activation of the ANXA2\/NF-\u03baB axis in Kupffer cells, contributing to the inflammatory response. TAGLN2 exacerbates AP-induced liver injury by enhancing hepatocyte pyroptosis through Kupffer cell-mediated inflammatory activation of the ANXA2\/NF-\u03baB axis. Targeting TAGLN2 may offer a potential therapeutic strategy for mitigating liver injury in AP.\n                  <\/jats:p>","DOI":"10.2478\/aite-2025-0014","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T15:34:43Z","timestamp":1749137683000},"source":"Crossref","is-referenced-by-count":3,"title":["TAGLN2 Exacerbates Acute Pancreatitis-Induced Liver Injury by Increasing Hepatocyte Pyroptosis via Kupffer Cells-Mediated Inflammatory Response"],"prefix":"10.2478","volume":"73","author":[{"given":"Huigeng","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of General Surgery , The First Affiliated Hospital of Dalian Medical University , Dalian , Liaoning , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalan","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of General Surgery , The First Affiliated Hospital of Dalian Medical University , Dalian , Liaoning , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of General Surgery , Affiliated Zhongshan Hospital of Dalian University , Dalian , Liaoning , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of General Surgery , Affiliated Zhongshan Hospital of Dalian University , Dalian , Liaoning , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zizhao","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of General Surgery , The First Affiliated Hospital of Dalian Medical University , Dalian , Liaoning , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of General Surgery , The First Affiliated Hospital of Dalian Medical University , Dalian , Liaoning , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,6,5]]},"reference":[{"key":"2026053122151837610_j_aite-2025-0014_ref_001","doi-asserted-by":"crossref","unstructured":"Almeida JI, Tenreiro MF, Martinez-Santamaria L et al. 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