{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T23:01:20Z","timestamp":1785020480805,"version":"3.55.0"},"reference-count":24,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Bladder cancer is a prevalent malignancy with a high recurrence rate, necessitating the identification of novel molecular targets for diagnosis and therapy. Recent studies have highlighted the role of long noncoding RNAs (lncRNAs) in cancer progression. This study aims to investigate the role of the lncRNA\n                    <jats:italic>IDH1-AS1<\/jats:italic>\n                    in bladder cancer, focusing on its effects on tumor growth, cell proliferation, and autophagy-related protein expression. We utilized both\n                    <jats:italic>in vivo<\/jats:italic>\n                    and\n                    <jats:italic>in vitro<\/jats:italic>\n                    models to assess the impact of\n                    <jats:italic>IDH1-AS1<\/jats:italic>\n                    overexpression and knockdown. Tumor growth was evaluated in nude mice model of bladder cancer, while cell proliferation was measured using the EDU assay. Protein expression levels of Beclin1,\n                    <jats:italic>P62<\/jats:italic>\n                    , and LC3 were determined by Western Blot analysis. Gene expression of\n                    <jats:italic>IDH1-AS1<\/jats:italic>\n                    was quantified using quantitative polymerase chain reaction (qPCR). Overexpression of\n                    <jats:italic>IDH1-AS1<\/jats:italic>\n                    in nude mice model of bladder cancer led to a significant increase in tumor volume and weight, whereas knockdown of\n                    <jats:italic>IDH1-AS1<\/jats:italic>\n                    resulted in a substantial decrease in tumor size.\n                    <jats:italic>In vitro<\/jats:italic>\n                    ,\n                    <jats:italic>IDH1-AS1<\/jats:italic>\n                    overexpression significantly enhanced cell proliferation, while its knockdown reduced proliferation. Western Blot analysis revealed that\n                    <jats:italic>IDH1-AS1<\/jats:italic>\n                    overexpression increased the levels of autophagy-related proteins Beclin1 and LC3, and decreased\n                    <jats:italic>P62<\/jats:italic>\n                    protein levels, with contrary effects observed upon\n                    <jats:italic>IDH1-AS1<\/jats:italic>\n                    knockdown. qPCR confirmed successful modulation of\n                    <jats:italic>IDH1-AS1<\/jats:italic>\n                    expression in experimental groups. Our findings indicate that\n                    <jats:italic>IDH1-AS1<\/jats:italic>\n                    promotes tumor growth and cell proliferation in bladder cancer, potentially through the regulation of autophagy-related proteins. These results suggest that\n                    <jats:italic>IDH1-AS1<\/jats:italic>\n                    could serve as a novel biomarker and therapeutic target for bladder cancer.\n                  <\/jats:p>","DOI":"10.2478\/aite-2026-0011","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T12:55:50Z","timestamp":1776948950000},"source":"Crossref","is-referenced-by-count":0,"title":["<i>Fusobacterium nucleatum<\/i>\n                    Promotes Bladder Cancer Development Through lncRNA\n                    <i>IDH1-AS1<\/i>\n                    -Mediated Autophagy"],"prefix":"10.2478","volume":"74","author":[{"given":"JunJie","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Urology , Lanxi People's Hospital , Lanxi , Zhejiang , , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BiYan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacy , Lanxi People's Hospital , Lanxi , Zhejiang , , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XiaoYuan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Urology , Lanxi People's Hospital , Lanxi , Zhejiang , , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ShuYing","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Urology , Lanxi People's Hospital , Lanxi , Zhejiang , , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shui","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Urology , Lanxi People's Hospital , Lanxi , Zhejiang , , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YueJun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology , Lanxi People's Hospital , Lanxi , Zhejiang , , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GaoYin","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Urology , Lanxi People's Hospital , Lanxi , Zhejiang , , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,3,31]]},"reference":[{"key":"2026072522431264816_j_aite-2026-0011_ref_001","doi-asserted-by":"crossref","unstructured":"Bonney A, Malouf R, Marchal C et al. 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